Environmental risk factors for oesophageal cancer in Malawi: A case-control study
Identifieur interne : 001717 ( Main/Exploration ); précédent : 001716; suivant : 001718Environmental risk factors for oesophageal cancer in Malawi: A case-control study
Auteurs : Yb Mlombe [Malawi] ; Ne Rosenberg [Malawi, États-Unis] ; Ll Wolf [Malawi] ; Cp Dzamalala [Malawi] ; K. Chalulu [Malawi] ; J. Chisi [Malawi] ; Nj Shaheen [États-Unis] ; Mc Hosseinipour [Malawi, États-Unis] ; Cg Shores [États-Unis]Source :
- Malawi Medical Journal [ 1995-7262 ] ; 2015.
Abstract
There is a high burden of oesophageal cancer in Malawi with dismal outcomes. It is not known whether environmental factors are associated with oesophageal cancer. Without knowing this critical information, prevention interventions are not possible. The purpose of this analysis was to explore environmental factors associated with oesophageal cancer in the Malawian context.
A hospital-based case-control study of the association between environmental risk factors and oesophageal cancer was conducted at Kamuzu Central Hospital in Lilongwe, Malawi and Queen Elizabeth Central Hospital in Blantyre, Malawi. Ninety-six persons with squamous cell carcinoma and 180 controls were enrolled and analyzed. These two groups were compared for a range of environmental risk factors, using logistic regression models. Unadjusted and adjusted odds ratios and 95% confidence intervals (CI) were calculated.
Firewood cooking, cigarette smoking, and use of white maize flour all had strong associations with squamous cell carcinoma of the oesophagus, with adjusted odds ratios of 12.6 (95% CI: 4.2–37.7), 5.4 (95% CI: 2.0–15.2) and 6.6 (95% CI: 2.3–19.3), respectively.
Several modifiable risk factors were found to be strongly associated with squamous cell carcinoma. Research is needed to confirm these associations and then determine how to intervene on these modifiable risk factors in the Malawian context.
Url:
PubMed: 26715952
PubMed Central: 4688868
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000042
- to stream Pmc, to step Curation: 000042
- to stream Pmc, to step Checkpoint: 000D59
- to stream Ncbi, to step Merge: 003529
- to stream Ncbi, to step Curation: 003529
- to stream Ncbi, to step Checkpoint: 003529
- to stream Main, to step Merge: 001718
- to stream Main, to step Curation: 001717
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Environmental risk factors for oesophageal cancer in Malawi: A case-control study</title>
<author><name sortKey="Mlombe, Yb" sort="Mlombe, Yb" uniqKey="Mlombe Y" first="Yb" last="Mlombe">Yb Mlombe</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> College of Medicine, University of Malawi, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rosenberg, Ne" sort="Rosenberg, Ne" uniqKey="Rosenberg N" first="Ne" last="Rosenberg">Ne Rosenberg</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> UNC Project-Malawi, Lilongwe, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> UNC Project-Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolf, Ll" sort="Wolf, Ll" uniqKey="Wolf L" first="Ll" last="Wolf">Ll Wolf</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> UNC Project-Malawi, Lilongwe, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> UNC Project-Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dzamalala, Cp" sort="Dzamalala, Cp" uniqKey="Dzamalala C" first="Cp" last="Dzamalala">Cp Dzamalala</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> College of Medicine, University of Malawi, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chalulu, K" sort="Chalulu, K" uniqKey="Chalulu K" first="K" last="Chalulu">K. Chalulu</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Queen Elizabeth Central Hospital, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> Queen Elizabeth Central Hospital, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chisi, J" sort="Chisi, J" uniqKey="Chisi J" first="J" last="Chisi">J. Chisi</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> College of Medicine, University of Malawi, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shaheen, Nj" sort="Shaheen, Nj" uniqKey="Shaheen N" first="Nj" last="Shaheen">Nj Shaheen</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hosseinipour, Mc" sort="Hosseinipour, Mc" uniqKey="Hosseinipour M" first="Mc" last="Hosseinipour">Mc Hosseinipour</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> UNC Project-Malawi, Lilongwe, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> UNC Project-Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shores, Cg" sort="Shores, Cg" uniqKey="Shores C" first="Cg" last="Shores">Cg Shores</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26715952</idno>
<idno type="pmc">4688868</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688868</idno>
<idno type="RBID">PMC:4688868</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000042</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000042</idno>
<idno type="wicri:Area/Pmc/Curation">000042</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000042</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D59</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D59</idno>
<idno type="wicri:Area/Ncbi/Merge">003529</idno>
<idno type="wicri:Area/Ncbi/Curation">003529</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003529</idno>
<idno type="wicri:doubleKey">1995-7262:2015:Mlombe Y:environmental:risk:factors</idno>
<idno type="wicri:Area/Main/Merge">001718</idno>
<idno type="wicri:Area/Main/Curation">001717</idno>
<idno type="wicri:Area/Main/Exploration">001717</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Environmental risk factors for oesophageal cancer in Malawi: A case-control study</title>
<author><name sortKey="Mlombe, Yb" sort="Mlombe, Yb" uniqKey="Mlombe Y" first="Yb" last="Mlombe">Yb Mlombe</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> College of Medicine, University of Malawi, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rosenberg, Ne" sort="Rosenberg, Ne" uniqKey="Rosenberg N" first="Ne" last="Rosenberg">Ne Rosenberg</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> UNC Project-Malawi, Lilongwe, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> UNC Project-Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolf, Ll" sort="Wolf, Ll" uniqKey="Wolf L" first="Ll" last="Wolf">Ll Wolf</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> UNC Project-Malawi, Lilongwe, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> UNC Project-Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dzamalala, Cp" sort="Dzamalala, Cp" uniqKey="Dzamalala C" first="Cp" last="Dzamalala">Cp Dzamalala</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> College of Medicine, University of Malawi, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chalulu, K" sort="Chalulu, K" uniqKey="Chalulu K" first="K" last="Chalulu">K. Chalulu</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Queen Elizabeth Central Hospital, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> Queen Elizabeth Central Hospital, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chisi, J" sort="Chisi, J" uniqKey="Chisi J" first="J" last="Chisi">J. Chisi</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> College of Medicine, University of Malawi, Blantyre</wicri:regionArea>
<wicri:noRegion>Blantyre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shaheen, Nj" sort="Shaheen, Nj" uniqKey="Shaheen N" first="Nj" last="Shaheen">Nj Shaheen</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hosseinipour, Mc" sort="Hosseinipour, Mc" uniqKey="Hosseinipour M" first="Mc" last="Hosseinipour">Mc Hosseinipour</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> UNC Project-Malawi, Lilongwe, Malawi</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea> UNC Project-Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shores, Cg" sort="Shores, Cg" uniqKey="Shores C" first="Cg" last="Shores">Cg Shores</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Malawi Medical Journal</title>
<idno type="ISSN">1995-7262</idno>
<idno type="eISSN">1995-7270</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Aim</title>
<p>There is a high burden of oesophageal cancer in Malawi with dismal outcomes. It is not known whether environmental factors are associated with oesophageal cancer. Without knowing this critical information, prevention interventions are not possible. The purpose of this analysis was to explore environmental factors associated with oesophageal cancer in the Malawian context.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>A hospital-based case-control study of the association between environmental risk factors and oesophageal cancer was conducted at Kamuzu Central Hospital in Lilongwe, Malawi and Queen Elizabeth Central Hospital in Blantyre, Malawi. Ninety-six persons with squamous cell carcinoma and 180 controls were enrolled and analyzed. These two groups were compared for a range of environmental risk factors, using logistic regression models. Unadjusted and adjusted odds ratios and 95% confidence intervals (CI) were calculated.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>Firewood cooking, cigarette smoking, and use of white maize flour all had strong associations with squamous cell carcinoma of the oesophagus, with adjusted odds ratios of 12.6 (95% CI: 4.2–37.7), 5.4 (95% CI: 2.0–15.2) and 6.6 (95% CI: 2.3–19.3), respectively.</p>
</sec>
<sec sec-type="conclusions"><title>Conclusions</title>
<p>Several modifiable risk factors were found to be strongly associated with squamous cell carcinoma. Research is needed to confirm these associations and then determine how to intervene on these modifiable risk factors in the Malawian context.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Malawi</li>
<li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
</region>
</list>
<tree><country name="Malawi"><noRegion><name sortKey="Mlombe, Yb" sort="Mlombe, Yb" uniqKey="Mlombe Y" first="Yb" last="Mlombe">Yb Mlombe</name>
</noRegion>
<name sortKey="Chalulu, K" sort="Chalulu, K" uniqKey="Chalulu K" first="K" last="Chalulu">K. Chalulu</name>
<name sortKey="Chisi, J" sort="Chisi, J" uniqKey="Chisi J" first="J" last="Chisi">J. Chisi</name>
<name sortKey="Dzamalala, Cp" sort="Dzamalala, Cp" uniqKey="Dzamalala C" first="Cp" last="Dzamalala">Cp Dzamalala</name>
<name sortKey="Hosseinipour, Mc" sort="Hosseinipour, Mc" uniqKey="Hosseinipour M" first="Mc" last="Hosseinipour">Mc Hosseinipour</name>
<name sortKey="Rosenberg, Ne" sort="Rosenberg, Ne" uniqKey="Rosenberg N" first="Ne" last="Rosenberg">Ne Rosenberg</name>
<name sortKey="Wolf, Ll" sort="Wolf, Ll" uniqKey="Wolf L" first="Ll" last="Wolf">Ll Wolf</name>
</country>
<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Rosenberg, Ne" sort="Rosenberg, Ne" uniqKey="Rosenberg N" first="Ne" last="Rosenberg">Ne Rosenberg</name>
</region>
<name sortKey="Hosseinipour, Mc" sort="Hosseinipour, Mc" uniqKey="Hosseinipour M" first="Mc" last="Hosseinipour">Mc Hosseinipour</name>
<name sortKey="Shaheen, Nj" sort="Shaheen, Nj" uniqKey="Shaheen N" first="Nj" last="Shaheen">Nj Shaheen</name>
<name sortKey="Shores, Cg" sort="Shores, Cg" uniqKey="Shores C" first="Cg" last="Shores">Cg Shores</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001717 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001717 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4688868 |texte= Environmental risk factors for oesophageal cancer in Malawi: A case-control study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26715952" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |