Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.
Identifieur interne : 000A89 ( Main/Exploration ); précédent : 000A88; suivant : 000A90Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.
Auteurs : Nobubelo K. Ngandu [Afrique du Sud] ; Jonathan M. Carlson ; Denis R. Chopera ; Nonkululeko Ndabambi ; Quarraisha Abdool Karim ; Salim Abdool Karim ; Carolyn WilliamsonSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1944-7884 ] ; 2017.
Descripteurs français
- KwdFr :
- Agents antiVIH (administration et posologie), Agents antiVIH (pharmacologie), Agents antiVIH (usage thérapeutique), Analyse de séquence d'ADN, Anti-infectieux (administration et posologie), Anti-infectieux (pharmacologie), Anti-infectieux (usage thérapeutique), Charge virale, Crèmes, mousses et gels vaginaux (usage thérapeutique), Essais cliniques comme sujet, Femelle, Humains, Infections à VIH (), Infections à VIH (transmission), Infections à VIH (virologie), Phylogénie, Produits du gène gag du virus de l'immunodéficience humaine (génétique), Prophylaxie pré-exposition, République d'Afrique du Sud (épidémiologie), Résultat thérapeutique, Ténofovir (usage thérapeutique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique).
- MESH :
- administration et posologie : Agents antiVIH, Anti-infectieux.
- génétique : Produits du gène gag du virus de l'immunodéficience humaine, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- pharmacologie : Agents antiVIH, Anti-infectieux.
- usage thérapeutique : Agents antiVIH, Anti-infectieux, Crèmes, mousses et gels vaginaux, Infections à VIH, Ténofovir.
- virologie : Infections à VIH.
- épidémiologie : République d'Afrique du Sud.
- Analyse de séquence d'ADN, Charge virale, Essais cliniques comme sujet, Femelle, Humains, Infections à VIH, Phylogénie, Prophylaxie pré-exposition, Résultat thérapeutique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- Anti-HIV Agents (administration & dosage), Anti-HIV Agents (pharmacology), Anti-HIV Agents (therapeutic use), Anti-Infective Agents (administration & dosage), Anti-Infective Agents (pharmacology), Anti-Infective Agents (therapeutic use), Clinical Trials as Topic, Female, HIV Infections (prevention & control), HIV Infections (transmission), HIV Infections (virology), HIV-1 (drug effects), HIV-1 (genetics), Humans, Phylogeny, Pre-Exposure Prophylaxis, Sequence Analysis, DNA, South Africa (epidemiology), Tenofovir (therapeutic use), Treatment Outcome, Vaginal Creams, Foams, and Jellies (therapeutic use), Viral Load, gag Gene Products, Human Immunodeficiency Virus (genetics).
- MESH :
- chemical , administration & dosage : Anti-HIV Agents, Anti-Infective Agents.
- chemical , genetics : gag Gene Products, Human Immunodeficiency Virus.
- chemical , pharmacology : Anti-HIV Agents, Anti-Infective Agents.
- chemical , therapeutic use : Anti-HIV Agents, Anti-Infective Agents, Tenofovir, Vaginal Creams, Foams, and Jellies.
- drug effects : HIV-1.
- epidemiology : South Africa.
- genetics : HIV-1.
- prevention & control : HIV Infections.
- transmission : HIV Infections.
- virology : HIV Infections.
- Clinical Trials as Topic, Female, Humans, Phylogeny, Pre-Exposure Prophylaxis, Sequence Analysis, DNA, Treatment Outcome, Viral Load.
Abstract
Women in the CAPRISA 004 trial assigned to use 1% tenofovir (TFV) microbicide gel, who became HIV-1 infected, had higher viral load set-point and slower antibody avidity maturation compared with placebo participants. We investigated whether TFV gel was selected for viruses with altered genetic characteristics.
DOI: 10.1097/QAI.0000000000001458
PubMed: 28797020
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000984
- to stream PubMed, to step Curation: 000984
- to stream PubMed, to step Checkpoint: 000984
- to stream Ncbi, to step Merge: 004539
- to stream Ncbi, to step Curation: 004539
- to stream Ncbi, to step Checkpoint: 004539
- to stream Main, to step Merge: 000A89
- to stream Main, to step Curation: 000A89
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.</title>
<author><name sortKey="Ngandu, Nobubelo K" sort="Ngandu, Nobubelo K" uniqKey="Ngandu N" first="Nobubelo K" last="Ngandu">Nobubelo K. Ngandu</name>
<affiliation wicri:level="1"><nlm:affiliation>*Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa;†Currently, Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa;‡Microsoft Research, Redmond, WA; and§Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>*Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa;†Currently, Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa;‡Microsoft Research, Redmond, WA; and§Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban</wicri:regionArea>
<wicri:noRegion>Durban</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carlson, Jonathan M" sort="Carlson, Jonathan M" uniqKey="Carlson J" first="Jonathan M" last="Carlson">Jonathan M. Carlson</name>
</author>
<author><name sortKey="Chopera, Denis R" sort="Chopera, Denis R" uniqKey="Chopera D" first="Denis R" last="Chopera">Denis R. Chopera</name>
</author>
<author><name sortKey="Ndabambi, Nonkululeko" sort="Ndabambi, Nonkululeko" uniqKey="Ndabambi N" first="Nonkululeko" last="Ndabambi">Nonkululeko Ndabambi</name>
</author>
<author><name sortKey="Abdool Karim, Quarraisha" sort="Abdool Karim, Quarraisha" uniqKey="Abdool Karim Q" first="Quarraisha" last="Abdool Karim">Quarraisha Abdool Karim</name>
</author>
<author><name sortKey="Abdool Karim, Salim" sort="Abdool Karim, Salim" uniqKey="Abdool Karim S" first="Salim" last="Abdool Karim">Salim Abdool Karim</name>
</author>
<author><name sortKey="Williamson, Carolyn" sort="Williamson, Carolyn" uniqKey="Williamson C" first="Carolyn" last="Williamson">Carolyn Williamson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28797020</idno>
<idno type="pmid">28797020</idno>
<idno type="doi">10.1097/QAI.0000000000001458</idno>
<idno type="wicri:Area/PubMed/Corpus">000984</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000984</idno>
<idno type="wicri:Area/PubMed/Curation">000984</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000984</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000984</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000984</idno>
<idno type="wicri:Area/Ncbi/Merge">004539</idno>
<idno type="wicri:Area/Ncbi/Curation">004539</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004539</idno>
<idno type="wicri:Area/Main/Merge">000A89</idno>
<idno type="wicri:Area/Main/Curation">000A89</idno>
<idno type="wicri:Area/Main/Exploration">000A89</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.</title>
<author><name sortKey="Ngandu, Nobubelo K" sort="Ngandu, Nobubelo K" uniqKey="Ngandu N" first="Nobubelo K" last="Ngandu">Nobubelo K. Ngandu</name>
<affiliation wicri:level="1"><nlm:affiliation>*Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa;†Currently, Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa;‡Microsoft Research, Redmond, WA; and§Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>*Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa;†Currently, Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa;‡Microsoft Research, Redmond, WA; and§Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban</wicri:regionArea>
<wicri:noRegion>Durban</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carlson, Jonathan M" sort="Carlson, Jonathan M" uniqKey="Carlson J" first="Jonathan M" last="Carlson">Jonathan M. Carlson</name>
</author>
<author><name sortKey="Chopera, Denis R" sort="Chopera, Denis R" uniqKey="Chopera D" first="Denis R" last="Chopera">Denis R. Chopera</name>
</author>
<author><name sortKey="Ndabambi, Nonkululeko" sort="Ndabambi, Nonkululeko" uniqKey="Ndabambi N" first="Nonkululeko" last="Ndabambi">Nonkululeko Ndabambi</name>
</author>
<author><name sortKey="Abdool Karim, Quarraisha" sort="Abdool Karim, Quarraisha" uniqKey="Abdool Karim Q" first="Quarraisha" last="Abdool Karim">Quarraisha Abdool Karim</name>
</author>
<author><name sortKey="Abdool Karim, Salim" sort="Abdool Karim, Salim" uniqKey="Abdool Karim S" first="Salim" last="Abdool Karim">Salim Abdool Karim</name>
</author>
<author><name sortKey="Williamson, Carolyn" sort="Williamson, Carolyn" uniqKey="Williamson C" first="Carolyn" last="Williamson">Carolyn Williamson</name>
</author>
</analytic>
<series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title>
<idno type="eISSN">1944-7884</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (administration & dosage)</term>
<term>Anti-HIV Agents (pharmacology)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>Anti-Infective Agents (administration & dosage)</term>
<term>Anti-Infective Agents (pharmacology)</term>
<term>Anti-Infective Agents (therapeutic use)</term>
<term>Clinical Trials as Topic</term>
<term>Female</term>
<term>HIV Infections (prevention & control)</term>
<term>HIV Infections (transmission)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (drug effects)</term>
<term>HIV-1 (genetics)</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Pre-Exposure Prophylaxis</term>
<term>Sequence Analysis, DNA</term>
<term>South Africa (epidemiology)</term>
<term>Tenofovir (therapeutic use)</term>
<term>Treatment Outcome</term>
<term>Vaginal Creams, Foams, and Jellies (therapeutic use)</term>
<term>Viral Load</term>
<term>gag Gene Products, Human Immunodeficiency Virus (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (administration et posologie)</term>
<term>Agents antiVIH (pharmacologie)</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Analyse de séquence d'ADN</term>
<term>Anti-infectieux (administration et posologie)</term>
<term>Anti-infectieux (pharmacologie)</term>
<term>Anti-infectieux (usage thérapeutique)</term>
<term>Charge virale</term>
<term>Crèmes, mousses et gels vaginaux (usage thérapeutique)</term>
<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH ()</term>
<term>Infections à VIH (transmission)</term>
<term>Infections à VIH (virologie)</term>
<term>Phylogénie</term>
<term>Produits du gène gag du virus de l'immunodéficience humaine (génétique)</term>
<term>Prophylaxie pré-exposition</term>
<term>République d'Afrique du Sud (épidémiologie)</term>
<term>Résultat thérapeutique</term>
<term>Ténofovir (usage thérapeutique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Anti-Infective Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>gag Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Anti-Infective Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Anti-Infective Agents</term>
<term>Tenofovir</term>
<term>Vaginal Creams, Foams, and Jellies</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Agents antiVIH</term>
<term>Anti-infectieux</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>South Africa</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Produits du gène gag du virus de l'immunodéficience humaine</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term>
<term>Anti-infectieux</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
<term>Anti-infectieux</term>
<term>Crèmes, mousses et gels vaginaux</term>
<term>Infections à VIH</term>
<term>Ténofovir</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>République d'Afrique du Sud</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term>
<term>Female</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Pre-Exposure Prophylaxis</term>
<term>Sequence Analysis, DNA</term>
<term>Treatment Outcome</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term>
<term>Charge virale</term>
<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH</term>
<term>Phylogénie</term>
<term>Prophylaxie pré-exposition</term>
<term>Résultat thérapeutique</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Women in the CAPRISA 004 trial assigned to use 1% tenofovir (TFV) microbicide gel, who became HIV-1 infected, had higher viral load set-point and slower antibody avidity maturation compared with placebo participants. We investigated whether TFV gel was selected for viruses with altered genetic characteristics.</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
</country>
</list>
<tree><noCountry><name sortKey="Abdool Karim, Quarraisha" sort="Abdool Karim, Quarraisha" uniqKey="Abdool Karim Q" first="Quarraisha" last="Abdool Karim">Quarraisha Abdool Karim</name>
<name sortKey="Abdool Karim, Salim" sort="Abdool Karim, Salim" uniqKey="Abdool Karim S" first="Salim" last="Abdool Karim">Salim Abdool Karim</name>
<name sortKey="Carlson, Jonathan M" sort="Carlson, Jonathan M" uniqKey="Carlson J" first="Jonathan M" last="Carlson">Jonathan M. Carlson</name>
<name sortKey="Chopera, Denis R" sort="Chopera, Denis R" uniqKey="Chopera D" first="Denis R" last="Chopera">Denis R. Chopera</name>
<name sortKey="Ndabambi, Nonkululeko" sort="Ndabambi, Nonkululeko" uniqKey="Ndabambi N" first="Nonkululeko" last="Ndabambi">Nonkululeko Ndabambi</name>
<name sortKey="Williamson, Carolyn" sort="Williamson, Carolyn" uniqKey="Williamson C" first="Carolyn" last="Williamson">Carolyn Williamson</name>
</noCountry>
<country name="Afrique du Sud"><noRegion><name sortKey="Ngandu, Nobubelo K" sort="Ngandu, Nobubelo K" uniqKey="Ngandu N" first="Nobubelo K" last="Ngandu">Nobubelo K. Ngandu</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A89 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A89 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:28797020 |texte= Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28797020" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |