Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.
Identifieur interne : 004539 ( Ncbi/Merge ); précédent : 004538; suivant : 004540Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.
Auteurs : Nobubelo K. Ngandu [Afrique du Sud] ; Jonathan M. Carlson ; Denis R. Chopera ; Nonkululeko Ndabambi ; Quarraisha Abdool Karim ; Salim Abdool Karim ; Carolyn WilliamsonSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1944-7884 ] ; 2017.
Descripteurs français
- KwdFr :
- Agents antiVIH (administration et posologie), Agents antiVIH (pharmacologie), Agents antiVIH (usage thérapeutique), Analyse de séquence d'ADN, Anti-infectieux (administration et posologie), Anti-infectieux (pharmacologie), Anti-infectieux (usage thérapeutique), Charge virale, Crèmes, mousses et gels vaginaux (usage thérapeutique), Essais cliniques comme sujet, Femelle, Humains, Infections à VIH (), Infections à VIH (transmission), Infections à VIH (virologie), Phylogénie, Produits du gène gag du virus de l'immunodéficience humaine (génétique), Prophylaxie pré-exposition, République d'Afrique du Sud (épidémiologie), Résultat thérapeutique, Ténofovir (usage thérapeutique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique).
- MESH :
- administration et posologie : Agents antiVIH, Anti-infectieux.
- génétique : Produits du gène gag du virus de l'immunodéficience humaine, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- pharmacologie : Agents antiVIH, Anti-infectieux.
- usage thérapeutique : Agents antiVIH, Anti-infectieux, Crèmes, mousses et gels vaginaux, Infections à VIH, Ténofovir.
- virologie : Infections à VIH.
- épidémiologie : République d'Afrique du Sud.
- Analyse de séquence d'ADN, Charge virale, Essais cliniques comme sujet, Femelle, Humains, Infections à VIH, Phylogénie, Prophylaxie pré-exposition, Résultat thérapeutique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- Anti-HIV Agents (administration & dosage), Anti-HIV Agents (pharmacology), Anti-HIV Agents (therapeutic use), Anti-Infective Agents (administration & dosage), Anti-Infective Agents (pharmacology), Anti-Infective Agents (therapeutic use), Clinical Trials as Topic, Female, HIV Infections (prevention & control), HIV Infections (transmission), HIV Infections (virology), HIV-1 (drug effects), HIV-1 (genetics), Humans, Phylogeny, Pre-Exposure Prophylaxis, Sequence Analysis, DNA, South Africa (epidemiology), Tenofovir (therapeutic use), Treatment Outcome, Vaginal Creams, Foams, and Jellies (therapeutic use), Viral Load, gag Gene Products, Human Immunodeficiency Virus (genetics).
- MESH :
- chemical , administration & dosage : Anti-HIV Agents, Anti-Infective Agents.
- chemical , genetics : gag Gene Products, Human Immunodeficiency Virus.
- chemical , pharmacology : Anti-HIV Agents, Anti-Infective Agents.
- chemical , therapeutic use : Anti-HIV Agents, Anti-Infective Agents, Tenofovir, Vaginal Creams, Foams, and Jellies.
- drug effects : HIV-1.
- epidemiology : South Africa.
- genetics : HIV-1.
- prevention & control : HIV Infections.
- transmission : HIV Infections.
- virology : HIV Infections.
- Clinical Trials as Topic, Female, Humans, Phylogeny, Pre-Exposure Prophylaxis, Sequence Analysis, DNA, Treatment Outcome, Viral Load.
Abstract
Women in the CAPRISA 004 trial assigned to use 1% tenofovir (TFV) microbicide gel, who became HIV-1 infected, had higher viral load set-point and slower antibody avidity maturation compared with placebo participants. We investigated whether TFV gel was selected for viruses with altered genetic characteristics.
DOI: 10.1097/QAI.0000000000001458
PubMed: 28797020
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000984
- to stream PubMed, to step Curation: 000984
- to stream PubMed, to step Checkpoint: 000984
Links to Exploration step
pubmed:28797020Le document en format XML
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<front><div type="abstract" xml:lang="en">Women in the CAPRISA 004 trial assigned to use 1% tenofovir (TFV) microbicide gel, who became HIV-1 infected, had higher viral load set-point and slower antibody avidity maturation compared with placebo participants. We investigated whether TFV gel was selected for viruses with altered genetic characteristics.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28797020</PMID>
<DateCreated><Year>2017</Year>
<Month>08</Month>
<Day>10</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>10</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>10</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1944-7884</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>76</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>Sep</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of acquired immune deficiency syndromes (1999)</Title>
<ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation>
</Journal>
<ArticleTitle>Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.</ArticleTitle>
<Pagination><MedlinePgn>43-47</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/QAI.0000000000001458</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Women in the CAPRISA 004 trial assigned to use 1% tenofovir (TFV) microbicide gel, who became HIV-1 infected, had higher viral load set-point and slower antibody avidity maturation compared with placebo participants. We investigated whether TFV gel was selected for viruses with altered genetic characteristics.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">The participants of the CAPRISA 004 trial (n = 28 TFV and 43 placebo) were from KwaZulu-Natal Province, South Africa and were infected with HIV-1 subtype C. After HIV-1 diagnosis, they were recruited into the CAPRISA 002 cohort.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We analyzed gag sequences from the earliest time point post infection (within 3 months of estimated time of infection). Transmission index was measured using a model which predicts the likelihood of an amino acid to be transmitted. Phylogenetic distance from a regional consensus sequence was calculated from a maximum likelihood phylogenetic tree.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Transmission index and distance from the most common (consensus) sequence have been shown to be markers of transmission fitness. We found that viruses infecting TFV gel recipients were closer to the consensus sequence of regional strains (P = 0.003) and had higher transmission index (P = 0.01). The transmission index was weakly correlated with concomitant viral load (Spearman r = 0.22, P = 0.06).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Decreased acquisition risk may have increased the barrier to infection therefore selecting for fitter, more consensus-like viruses. Such virus fitness effects will need to be considered for future pre-exposure prophylaxis and vaccine trials.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ngandu</LastName>
<ForeName>Nobubelo K</ForeName>
<Initials>NK</Initials>
<AffiliationInfo><Affiliation>*Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa;†Currently, Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa;‡Microsoft Research, Redmond, WA; and§Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Carlson</LastName>
<ForeName>Jonathan M</ForeName>
<Initials>JM</Initials>
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<Author ValidYN="Y"><LastName>Chopera</LastName>
<ForeName>Denis R</ForeName>
<Initials>DR</Initials>
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<Author ValidYN="Y"><LastName>Ndabambi</LastName>
<ForeName>Nonkululeko</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Abdool Karim</LastName>
<ForeName>Quarraisha</ForeName>
<Initials>Q</Initials>
</Author>
<Author ValidYN="Y"><LastName>Abdool Karim</LastName>
<ForeName>Salim</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Williamson</LastName>
<ForeName>Carolyn</ForeName>
<Initials>C</Initials>
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