Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy.
Identifieur interne : 000834 ( PubMed/Corpus ); précédent : 000833; suivant : 000835Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy.
Auteurs : Symon M. Kariuki ; Angelina Kakooza-Mwesige ; Ryan G. Wagner ; Eddie Chengo ; Steven White ; Gathoni Kamuyu ; Anthony K. Ngugi ; Josemir W. Sander ; Brian G R. Neville ; Charles R J. NewtonSource :
- Neurology [ 1526-632X ] ; 2015.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Protozoan (immunology), Anticonvulsants (therapeutic use), Brain Diseases (epidemiology), Burns (epidemiology), Child, Educational Status, Epilepsy (drug therapy), Epilepsy (epidemiology), Female, HIV Antibodies (immunology), HIV Infections (epidemiology), HIV Infections (immunology), Hospitalization (statistics & numerical data), Humans, Kenya (epidemiology), Logistic Models, Malaria, Falciparum (epidemiology), Malaria, Falciparum (immunology), Male, Marital Status (statistics & numerical data), Medication Adherence (statistics & numerical data), Prevalence, Risk Factors, South Africa (epidemiology), Status Epilepticus (epidemiology), Status Epilepticus (mortality), Uganda (epidemiology), Unemployment (statistics & numerical data), Young Adult.
- MESH :
- chemical , immunology : Antibodies, Protozoan, HIV Antibodies.
- chemical , therapeutic use : Anticonvulsants.
- geographic , epidemiology : Kenya, South Africa, Uganda.
- drug therapy : Epilepsy.
- epidemiology : Brain Diseases, Burns, Epilepsy, HIV Infections, Malaria, Falciparum, Status Epilepticus.
- immunology : HIV Infections, Malaria, Falciparum.
- mortality : Status Epilepticus.
- statistics & numerical data : Hospitalization, Marital Status, Medication Adherence, Unemployment.
- Adolescent, Adult, Child, Educational Status, Female, Humans, Logistic Models, Male, Prevalence, Risk Factors, Young Adult.
Abstract
We conducted a community survey to estimate the prevalence and describe the features, risk factors, and consequences of convulsive status epilepticus (CSE) among people with active convulsive epilepsy (ACE) identified in a multisite survey in Africa.
DOI: 10.1212/WNL.0000000000001542
PubMed: 25841025
Links to Exploration step
pubmed:25841025Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy.</title><author><name sortKey="Kariuki, Symon M" sort="Kariuki, Symon M" uniqKey="Kariuki S" first="Symon M" last="Kariuki">Symon M. Kariuki</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK. skariuki@kemri-wellcome.org.</nlm:affiliation></affiliation></author><author><name sortKey="Kakooza Mwesige, Angelina" sort="Kakooza Mwesige, Angelina" uniqKey="Kakooza Mwesige A" first="Angelina" last="Kakooza-Mwesige">Angelina Kakooza-Mwesige</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wagner, Ryan G" sort="Wagner, Ryan G" uniqKey="Wagner R" first="Ryan G" last="Wagner">Ryan G. Wagner</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chengo, Eddie" sort="Chengo, Eddie" uniqKey="Chengo E" first="Eddie" last="Chengo">Eddie Chengo</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="White, Steven" sort="White, Steven" uniqKey="White S" first="Steven" last="White">Steven White</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kamuyu, Gathoni" sort="Kamuyu, Gathoni" uniqKey="Kamuyu G" first="Gathoni" last="Kamuyu">Gathoni Kamuyu</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ngugi, Anthony K" sort="Ngugi, Anthony K" uniqKey="Ngugi A" first="Anthony K" last="Ngugi">Anthony K. Ngugi</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sander, Josemir W" sort="Sander, Josemir W" uniqKey="Sander J" first="Josemir W" last="Sander">Josemir W. Sander</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Neville, Brian G R" sort="Neville, Brian G R" uniqKey="Neville B" first="Brian G R" last="Neville">Brian G R. Neville</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Newton, Charles R J" sort="Newton, Charles R J" uniqKey="Newton C" first="Charles R J" last="Newton">Charles R J. Newton</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25841025</idno><idno type="pmid">25841025</idno><idno type="doi">10.1212/WNL.0000000000001542</idno><idno type="wicri:Area/PubMed/Corpus">000834</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000834</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy.</title><author><name sortKey="Kariuki, Symon M" sort="Kariuki, Symon M" uniqKey="Kariuki S" first="Symon M" last="Kariuki">Symon M. Kariuki</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK. skariuki@kemri-wellcome.org.</nlm:affiliation></affiliation></author><author><name sortKey="Kakooza Mwesige, Angelina" sort="Kakooza Mwesige, Angelina" uniqKey="Kakooza Mwesige A" first="Angelina" last="Kakooza-Mwesige">Angelina Kakooza-Mwesige</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wagner, Ryan G" sort="Wagner, Ryan G" uniqKey="Wagner R" first="Ryan G" last="Wagner">Ryan G. Wagner</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chengo, Eddie" sort="Chengo, Eddie" uniqKey="Chengo E" first="Eddie" last="Chengo">Eddie Chengo</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="White, Steven" sort="White, Steven" uniqKey="White S" first="Steven" last="White">Steven White</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kamuyu, Gathoni" sort="Kamuyu, Gathoni" uniqKey="Kamuyu G" first="Gathoni" last="Kamuyu">Gathoni Kamuyu</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ngugi, Anthony K" sort="Ngugi, Anthony K" uniqKey="Ngugi A" first="Anthony K" last="Ngugi">Anthony K. Ngugi</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sander, Josemir W" sort="Sander, Josemir W" uniqKey="Sander J" first="Josemir W" last="Sander">Josemir W. Sander</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Neville, Brian G R" sort="Neville, Brian G R" uniqKey="Neville B" first="Brian G R" last="Neville">Brian G R. Neville</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Newton, Charles R J" sort="Newton, Charles R J" uniqKey="Newton C" first="Charles R J" last="Newton">Charles R J. Newton</name><affiliation><nlm:affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibodies, Protozoan (immunology)</term><term>Anticonvulsants (therapeutic use)</term><term>Brain Diseases (epidemiology)</term><term>Burns (epidemiology)</term><term>Child</term><term>Educational Status</term><term>Epilepsy (drug therapy)</term><term>Epilepsy (epidemiology)</term><term>Female</term><term>HIV Antibodies (immunology)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (immunology)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans</term><term>Kenya (epidemiology)</term><term>Logistic Models</term><term>Malaria, Falciparum (epidemiology)</term><term>Malaria, Falciparum (immunology)</term><term>Male</term><term>Marital Status (statistics & numerical data)</term><term>Medication Adherence (statistics & numerical data)</term><term>Prevalence</term><term>Risk Factors</term><term>South Africa (epidemiology)</term><term>Status Epilepticus (epidemiology)</term><term>Status Epilepticus (mortality)</term><term>Uganda (epidemiology)</term><term>Unemployment (statistics & numerical data)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Protozoan</term><term>HIV Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticonvulsants</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Kenya</term><term>South Africa</term><term>Uganda</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Epilepsy</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Brain Diseases</term><term>Burns</term><term>Epilepsy</term><term>HIV Infections</term><term>Malaria, Falciparum</term><term>Status Epilepticus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term><term>Malaria, Falciparum</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Status Epilepticus</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term><term>Marital Status</term><term>Medication Adherence</term><term>Unemployment</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Educational Status</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Prevalence</term><term>Risk Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a community survey to estimate the prevalence and describe the features, risk factors, and consequences of convulsive status epilepticus (CSE) among people with active convulsive epilepsy (ACE) identified in a multisite survey in Africa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25841025</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>05</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>18</Issue><PubDate><Year>2015</Year><Month>May</Month><Day>05</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy.</ArticleTitle><Pagination><MedlinePgn>1838-45</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0000000000001542</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We conducted a community survey to estimate the prevalence and describe the features, risk factors, and consequences of convulsive status epilepticus (CSE) among people with active convulsive epilepsy (ACE) identified in a multisite survey in Africa.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We obtained clinical histories of CSE and neurologic examination data among 1,196 people with ACE identified from a population of 379,166 people in 3 sites: Agincourt, South Africa; Iganga-Mayuge, Uganda; and Kilifi, Kenya. We performed serologic assessment for the presence of antibodies to parasitic infections and HIV and determined adherence to antiepileptic drugs. Consequences of CSE were assessed using a questionnaire. Logistic regression was used to identify risk factors.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The adjusted prevalence of CSE in ACE among the general population across the 3 sites was 2.3 per 1,000, and differed with site (p < 0.0001). Over half (55%) of CSE occurred in febrile illnesses and focal seizures were present in 61%. Risk factors for CSE in ACE were neurologic impairments, acute encephalopathy, previous hospitalization, and presence of antibody titers to falciparum malaria and HIV; these differed across sites. Burns (15%), lack of education (49%), being single (77%), and unemployment (78%) were common in CSE; these differed across the 3 sites. Nine percent with and 10% without CSE died.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">CSE is common in people with ACE in Africa; most occurs with febrile illnesses, is untreated, and has focal features suggesting preventable risk factors. Effective prevention and the management of infections and neurologic impairments may reduce the burden of CSE in ACE.</AbstractText><CopyrightInformation>© 2015 American Academy of Neurology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kariuki</LastName><ForeName>Symon M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK. skariuki@kemri-wellcome.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kakooza-Mwesige</LastName><ForeName>Angelina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Ryan G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chengo</LastName><ForeName>Eddie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamuyu</LastName><ForeName>Gathoni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngugi</LastName><ForeName>Anthony K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sander</LastName><ForeName>Josemir W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neville</LastName><ForeName>Brian G R</ForeName><Initials>BG</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newton</LastName><ForeName>Charles R J</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>From Kenya Medical Research Institute-Wellcome Trust Research Programme (S.M.K., E.C., G.K., A.K.N., C.R.J.N.), Kilifi, Kenya; Nuffield Department of Medicine (S.M.K.), University of Oxford, UK; Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network (A.K.-M., R.G.W., E.C., G.K., A.K.N., C.R.J.N.), Accra, Ghana; Iganga-Mayuge Health and Demographic Surveillance System (A.K.-M.), Iganga; the Department of Paediatrics and Child Health (A.K.-M.), Makerere University College of Health Sciences, Kampala, Uganda; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) (R.G.W.), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Global Health (R.G.W.), Department of Public Health and Clinical Medicine, Umeå University, Sweden; the Neurophysiology Department (S.W.), Great Ormond Street Hospital for Children, London; the Neurosciences Unit (B.G.R.N., C.R.J.N.), UCL Institute of Child Health, London, UK; Population Health Sciences/Research Support Unit (A.K.N.), Faculty of Health Sciences, Aga Khan University (East Africa), Nairobi, Kenya; NIHR University College London Hospitals Biomedical Research Centre (J.W.S.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S.), Bucks, UK; Stichting Epilepsie Instellingen Nederland-SEIN (J.W.S.), Heemstede, Netherlands; Clinical Research Unit (C.R.J.N.), London School of Hygiene and Tropical Medicine; and the Department of Psychiatry (C.R.J.N.), University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>SEEDS Writing Group</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>WT092654</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>083744</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>099782/Z/12/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000913">Antibodies, Protozoan</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000927">Anticonvulsants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015483">HIV Antibodies</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2007;48 Suppl 8:82-4</RefSource><PMID Version="1">18330009</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2013 Jun;54(6):990-1001</RefSource><PMID Version="1">23614351</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1990 May;40(5 Suppl 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