Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.
Identifieur interne : 000262 ( PubMed/Corpus ); précédent : 000261; suivant : 000263Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.
Auteurs : Christian Obirikorang ; Razak Gyesi Issahaku ; Derick Nii Mensah Osakunor ; James Osei-YeboahSource :
- AIDS research and treatment [ 2090-1240 ] ; 2016.
Abstract
Aim. We determined the prevalence of anaemia and evaluated markers of iron homeostasis in a cohort of HIV patients. Methods. A comparative cross-sectional study on 319 participants was carried out at the Tamale Teaching Hospital from July 2013 to December 2013, 219 patients on HAART (designated On-HAART) and 100 HAART-naive patients. Data gathered include sociodemography, clinical history, and selected laboratory assays. Results. Prevalence of anaemia was 23.8%. On-HAART participants had higher CD4/CD3 lymphocyte counts, Hb, HCT/PCV, MCV, MCH, iron, ferritin, and TSAT (P < 0.05). Hb, iron, ferritin, and TSAT decreased from grade 1 to grade 3 anaemia and CD4/CD3 lymphocyte count was lowest in grade 3 anaemia (P < 0.05). Iron (P = 0.0072) decreased with disease severity whilst transferrin (P = 0.0143) and TIBC (P = 0.0143) increased with disease severity. Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload. The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia). Conclusion. In this study population, HIV-associated anaemia is common and is related to HAART status and disease progression. HIV itself is the most important cause of anaemia and treatment of HIV should be a priority compared to iron supplementation.
DOI: 10.1155/2016/1623094
PubMed: 27092270
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.</title><author><name sortKey="Obirikorang, Christian" sort="Obirikorang, Christian" uniqKey="Obirikorang C" first="Christian" last="Obirikorang">Christian Obirikorang</name><affiliation><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Issahaku, Razak Gyesi" sort="Issahaku, Razak Gyesi" uniqKey="Issahaku R" first="Razak Gyesi" last="Issahaku">Razak Gyesi Issahaku</name><affiliation><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Medical Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Osakunor, Derick Nii Mensah" sort="Osakunor, Derick Nii Mensah" uniqKey="Osakunor D" first="Derick Nii Mensah" last="Osakunor">Derick Nii Mensah Osakunor</name><affiliation><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Osei Yeboah, James" sort="Osei Yeboah, James" uniqKey="Osei Yeboah J" first="James" last="Osei-Yeboah">James Osei-Yeboah</name><affiliation><nlm:affiliation>Department of Medical Laboratory Sciences, University of Health and Allied Sciences, Ho, Ghana.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27092270</idno><idno type="pmid">27092270</idno><idno type="doi">10.1155/2016/1623094</idno><idno type="wicri:Area/PubMed/Corpus">000262</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.</title><author><name sortKey="Obirikorang, Christian" sort="Obirikorang, Christian" uniqKey="Obirikorang C" first="Christian" last="Obirikorang">Christian Obirikorang</name><affiliation><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Issahaku, Razak Gyesi" sort="Issahaku, Razak Gyesi" uniqKey="Issahaku R" first="Razak Gyesi" last="Issahaku">Razak Gyesi Issahaku</name><affiliation><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Medical Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Osakunor, Derick Nii Mensah" sort="Osakunor, Derick Nii Mensah" uniqKey="Osakunor D" first="Derick Nii Mensah" last="Osakunor">Derick Nii Mensah Osakunor</name><affiliation><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Osei Yeboah, James" sort="Osei Yeboah, James" uniqKey="Osei Yeboah J" first="James" last="Osei-Yeboah">James Osei-Yeboah</name><affiliation><nlm:affiliation>Department of Medical Laboratory Sciences, University of Health and Allied Sciences, Ho, Ghana.</nlm:affiliation></affiliation></author></analytic><series><title level="j">AIDS research and treatment</title><idno type="ISSN">2090-1240</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aim. We determined the prevalence of anaemia and evaluated markers of iron homeostasis in a cohort of HIV patients. Methods. A comparative cross-sectional study on 319 participants was carried out at the Tamale Teaching Hospital from July 2013 to December 2013, 219 patients on HAART (designated On-HAART) and 100 HAART-naive patients. Data gathered include sociodemography, clinical history, and selected laboratory assays. Results. Prevalence of anaemia was 23.8%. On-HAART participants had higher CD4/CD3 lymphocyte counts, Hb, HCT/PCV, MCV, MCH, iron, ferritin, and TSAT (P < 0.05). Hb, iron, ferritin, and TSAT decreased from grade 1 to grade 3 anaemia and CD4/CD3 lymphocyte count was lowest in grade 3 anaemia (P < 0.05). Iron (P = 0.0072) decreased with disease severity whilst transferrin (P = 0.0143) and TIBC (P = 0.0143) increased with disease severity. Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload. The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia). Conclusion. In this study population, HIV-associated anaemia is common and is related to HAART status and disease progression. HIV itself is the most important cause of anaemia and treatment of HIV should be a priority compared to iron supplementation.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27092270</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>19</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2090-1240</ISSN><JournalIssue CitedMedium="Print"><Volume>2016</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>AIDS research and treatment</Title><ISOAbbreviation>AIDS Res Treat</ISOAbbreviation></Journal><ArticleTitle>Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.</ArticleTitle><Pagination><MedlinePgn>1623094</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2016/1623094</ELocationID><Abstract><AbstractText>Aim. We determined the prevalence of anaemia and evaluated markers of iron homeostasis in a cohort of HIV patients. Methods. A comparative cross-sectional study on 319 participants was carried out at the Tamale Teaching Hospital from July 2013 to December 2013, 219 patients on HAART (designated On-HAART) and 100 HAART-naive patients. Data gathered include sociodemography, clinical history, and selected laboratory assays. Results. Prevalence of anaemia was 23.8%. On-HAART participants had higher CD4/CD3 lymphocyte counts, Hb, HCT/PCV, MCV, MCH, iron, ferritin, and TSAT (P < 0.05). Hb, iron, ferritin, and TSAT decreased from grade 1 to grade 3 anaemia and CD4/CD3 lymphocyte count was lowest in grade 3 anaemia (P < 0.05). Iron (P = 0.0072) decreased with disease severity whilst transferrin (P = 0.0143) and TIBC (P = 0.0143) increased with disease severity. Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload. The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia). Conclusion. In this study population, HIV-associated anaemia is common and is related to HAART status and disease progression. HIV itself is the most important cause of anaemia and treatment of HIV should be a priority compared to iron supplementation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Obirikorang</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Issahaku</LastName><ForeName>Razak Gyesi</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Medical Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osakunor</LastName><ForeName>Derick Nii Mensah</ForeName><Initials>DN</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osei-Yeboah</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medical Laboratory Sciences, University of Health and Allied Sciences, Ho, Ghana.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>AIDS Res 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