[Reactivity differences between serums of patients infected with HIV-2 and HIV-1 antigens according to the patients' geographic origin].
Identifieur interne : 000940 ( PubMed/Checkpoint ); précédent : 000939; suivant : 000941[Reactivity differences between serums of patients infected with HIV-2 and HIV-1 antigens according to the patients' geographic origin].
Auteurs : F. Simon [France] ; I. Loussert-Ajaka ; G. Collin ; E. Gamba ; A. Powell-Smith ; S. Gadelle ; F. Brun-VézinetSource :
- Sante (Montrouge, France) [ 1157-5999 ]
Descripteurs français
- KwdFr :
- Afrique (ethnologie), Antigènes du VIH (immunologie), Dosage par radioimmunoprécipitation, France (épidémiologie), Humains, Infections à VIH (immunologie), Infections à VIH (sang), Infections à VIH (épidémiologie), Mali (épidémiologie), Réactions croisées, Surveillance de la population, Technique de Western, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (immunologie), Études séroépidémiologiques.
- MESH :
- ethnologie : Afrique.
- immunologie : Antigènes du VIH, Infections à VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2).
- sang : Infections à VIH.
- épidémiologie : France, Infections à VIH, Mali.
- Dosage par radioimmunoprécipitation, Humains, Réactions croisées, Surveillance de la population, Technique de Western, Techniques immunoenzymatiques, Études séroépidémiologiques.
- Wicri :
English descriptors
- KwdEn :
- Africa (ethnology), Blotting, Western, Cross Reactions, France (epidemiology), HIV Antigens (immunology), HIV Infections (blood), HIV Infections (epidemiology), HIV Infections (immunology), HIV-1 (immunology), HIV-2 (immunology), Humans, Immunoenzyme Techniques, Mali (epidemiology), Population Surveillance, Radioimmunoprecipitation Assay, Seroepidemiologic Studies.
- MESH :
- chemical , immunology : HIV Antigens.
- geographic , epidemiology : France, Mali.
- geographic , ethnology : Africa.
- blood : HIV Infections.
- epidemiology : HIV Infections.
- immunology : HIV Infections, HIV-1, HIV-2.
- Blotting, Western, Cross Reactions, Humans, Immunoenzyme Techniques, Population Surveillance, Radioimmunoprecipitation Assay, Seroepidemiologic Studies.
Abstract
We tested 98 sera from HIV-2-infected patients for cross-reactivity with HIV-1 antigens in a competitive EIA test and western blotting. The sera were obtained during epidemiological surveys in Cape Verde Islands (n = 47) and Mali (n = 51). There were significantly more cross reactions with sera from Mali. Similar results were obtained with sera from African patients resident in France. Samples from HIV-2-infected patients from Burkina Faso, Ghana, Ivory Coast and Mali were more often reactive with HIV-1 antigens than were those from HIV-2-infected patients from the western Atlantic coast (Cape Verde, Guinea Bissau and Senegal). These data underline the importance of using specific tests for HIV-2 sero-positivity, and the need to include a panel of HIV-2-positive sera of different geographic origins in quality control kits.
PubMed: 8162361
Affiliations:
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pubmed:8162361Le document en format XML
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<term>HIV Antigens (immunology)</term>
<term>HIV Infections (blood)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV Infections (immunology)</term>
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<term>Immunoenzyme Techniques</term>
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<term>Humains</term>
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<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
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<term>Surveillance de la population</term>
<term>Technique de Western</term>
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<front><div type="abstract" xml:lang="en">We tested 98 sera from HIV-2-infected patients for cross-reactivity with HIV-1 antigens in a competitive EIA test and western blotting. The sera were obtained during epidemiological surveys in Cape Verde Islands (n = 47) and Mali (n = 51). There were significantly more cross reactions with sera from Mali. Similar results were obtained with sera from African patients resident in France. Samples from HIV-2-infected patients from Burkina Faso, Ghana, Ivory Coast and Mali were more often reactive with HIV-1 antigens than were those from HIV-2-infected patients from the western Atlantic coast (Cape Verde, Guinea Bissau and Senegal). These data underline the importance of using specific tests for HIV-2 sero-positivity, and the need to include a panel of HIV-2-positive sera of different geographic origins in quality control kits.</div>
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<Abstract><AbstractText>We tested 98 sera from HIV-2-infected patients for cross-reactivity with HIV-1 antigens in a competitive EIA test and western blotting. The sera were obtained during epidemiological surveys in Cape Verde Islands (n = 47) and Mali (n = 51). There were significantly more cross reactions with sera from Mali. Similar results were obtained with sera from African patients resident in France. Samples from HIV-2-infected patients from Burkina Faso, Ghana, Ivory Coast and Mali were more often reactive with HIV-1 antigens than were those from HIV-2-infected patients from the western Atlantic coast (Cape Verde, Guinea Bissau and Senegal). These data underline the importance of using specific tests for HIV-2 sero-positivity, and the need to include a panel of HIV-2-positive sera of different geographic origins in quality control kits.</AbstractText>
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