SidaGhanaV1, PubMed, Checkpoint, bibRecord, 000590

Haptoglobin, inflammation and disease.

Identifieur interne : 000590 ( PubMed/Checkpoint ); précédent : 000589; suivant : 000591

Haptoglobin, inflammation and disease.

Auteurs : Isaac K. Quaye [Ghana]

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2008.

RBID : pubmed:18486167

Descripteurs français

KwdFr :
- Antioxydants (métabolisme), Chimiokines (métabolisme), Facteurs immunologiques (métabolisme), Granulocytes neutrophiles (métabolisme), Génotype, Haptoglobines (génétique), Haptoglobines (métabolisme), Humains, Inflammation (métabolisme), Interactions hôte-pathogène (génétique), Phénotype, Polymorphisme génétique (génétique), Résultat thérapeutique, Susceptibilité à une maladie.
MESH :
- génétique : Haptoglobines, Interactions hôte-pathogène, Polymorphisme génétique.
- métabolisme : Antioxydants, Chimiokines, Facteurs immunologiques, Granulocytes neutrophiles, Haptoglobines, Inflammation.
- Génotype, Humains, Phénotype, Résultat thérapeutique, Susceptibilité à une maladie.

English descriptors

KwdEn :
- Antioxidants (metabolism), Chemokines (metabolism), Disease Susceptibility, Genotype, Haptoglobins (genetics), Haptoglobins (metabolism), Host-Pathogen Interactions (genetics), Humans, Immunologic Factors (metabolism), Inflammation (metabolism), Neutrophils (metabolism), Phenotype, Polymorphism, Genetic (genetics), Treatment Outcome.
MESH :
- chemical , genetics : Haptoglobins.
- chemical , metabolism : Antioxidants, Chemokines, Haptoglobins, Immunologic Factors.
- genetics : Host-Pathogen Interactions, Polymorphism, Genetic.
- metabolism : Inflammation, Neutrophils.
- Disease Susceptibility, Genotype, Humans, Phenotype, Treatment Outcome.

Abstract

Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein's function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HIV, tuberculosis) and non-infectious diseases (diabetes, cardiovascular disease and obesity) among others. Phenotype-dependent poor disease outcomes have been linked with the Hp2-2 phenotype. The present review brings this association into perspective by looking at the functions of the protein and how defects in these functions associated with the Hp2 allele affect disease outcome. A model is provided to explain the mechanism, which appears to be largely immunomodulatory.

DOI: 10.1016/j.trstmh.2008.04.010
PubMed: 18486167

Affiliations:

Ghana

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Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, University of Ghana Medical School, Korle-Bu-Accra, Ghana. dr.quaye@gmail.com</nlm:affiliation>
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<term>Chimiokines (métabolisme)</term>
<term>Facteurs immunologiques (métabolisme)</term>
<term>Granulocytes neutrophiles (métabolisme)</term>
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<term>Polymorphisme génétique (génétique)</term>
<term>Résultat thérapeutique</term>
<term>Susceptibilité à une maladie</term>
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<term>Interactions hôte-pathogène</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term>
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<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein's function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HIV, tuberculosis) and non-infectious diseases (diabetes, cardiovascular disease and obesity) among others. Phenotype-dependent poor disease outcomes have been linked with the Hp2-2 phenotype. The present review brings this association into perspective by looking at the functions of the protein and how defects in these functions associated with the Hp2 allele affect disease outcome. A model is provided to explain the mechanism, which appears to be largely immunomodulatory.</div>
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Haptoglobin, inflammation and disease.

Haptoglobin, inflammation and disease.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki