Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial.
Identifieur interne : 000533 ( PubMed/Checkpoint ); précédent : 000532; suivant : 000534Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial.
Auteurs : George E. Armah [Ghana] ; Samba O. Sow ; Robert F. Breiman ; Michael J. Dallas ; Milagritos D. Tapia ; Daniel R. Feikin ; Fred N. Binka ; A Duncan Steele ; Kayla F. Laserson ; Nana A. Ansah ; Myron M. Levine ; Kristen Lewis ; Michele L. Coia ; Margaret Attah-Poku ; Joel Ojwando ; Stephen B. Rivers ; John C. Victor ; Geoffrey Nyambane ; Abraham Hodgson ; Florian Schödel ; Max Ciarlet ; Kathleen M. NeuzilSource :
- Lancet (London, England) [ 1474-547X ] ; 2010.
Descripteurs français
- KwdFr :
- Administration par voie orale, Afrique subsaharienne, Anticorps antiviraux (sang), Calendrier vaccinal, Gastroentérite (), Gastroentérite (virologie), Humains, Immunoglobuline A (sang), Indice de gravité médicale, Infections à rotavirus (), Infections à rotavirus (immunologie), Méthode en double aveugle, Nourrisson, Pays en voie de développement, Rotavirus (immunologie), Vaccins anti-rotavirus (administration et posologie), Vaccins anti-rotavirus (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (immunologie).
- MESH :
- administration et posologie : Vaccins anti-rotavirus, Vaccins atténués.
- immunologie : Infections à rotavirus, Rotavirus, Vaccins anti-rotavirus, Vaccins atténués.
- sang : Anticorps antiviraux, Immunoglobuline A.
- virologie : Gastroentérite.
- Administration par voie orale, Afrique subsaharienne, Calendrier vaccinal, Gastroentérite, Humains, Indice de gravité médicale, Infections à rotavirus, Méthode en double aveugle, Nourrisson, Pays en voie de développement.
English descriptors
- KwdEn :
- Administration, Oral, Africa South of the Sahara, Antibodies, Viral (blood), Developing Countries, Double-Blind Method, Gastroenteritis (prevention & control), Gastroenteritis (virology), Humans, Immunization Schedule, Immunoglobulin A (blood), Infant, Rotavirus (immunology), Rotavirus Infections (immunology), Rotavirus Infections (prevention & control), Rotavirus Vaccines (administration & dosage), Rotavirus Vaccines (immunology), Severity of Illness Index, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (immunology).
- MESH :
- chemical , administration & dosage : Rotavirus Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Viral, Immunoglobulin A.
- chemical , immunology : Rotavirus Vaccines, Vaccines, Attenuated.
- geographic : Africa South of the Sahara.
- immunology : Rotavirus, Rotavirus Infections.
- prevention & control : Gastroenteritis, Rotavirus Infections.
- virology : Gastroenteritis.
- Administration, Oral, Developing Countries, Double-Blind Method, Humans, Immunization Schedule, Infant, Severity of Illness Index.
Abstract
Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa. Because rotavirus vaccines have proven effective in developed countries but had not been tested in developing countries, we assessed efficacy of a pentavalent rotavirus vaccine against severe disease in Ghana, Kenya, and Mali between April, 2007, and March, 2009.
DOI: 10.1016/S0140-6736(10)60889-6
PubMed: 20692030
Affiliations:
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Armah</name><affiliation wicri:level="4"><nlm:affiliation>Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Sow, Samba O" sort="Sow, Samba O" uniqKey="Sow S" first="Samba O" last="Sow">Samba O. Sow</name></author><author><name sortKey="Breiman, Robert F" sort="Breiman, Robert F" uniqKey="Breiman R" first="Robert F" last="Breiman">Robert F. Breiman</name></author><author><name sortKey="Dallas, Michael J" sort="Dallas, Michael J" uniqKey="Dallas M" first="Michael J" last="Dallas">Michael J. 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Neuzil</name></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Africa South of the Sahara</term><term>Antibodies, Viral (blood)</term><term>Developing Countries</term><term>Double-Blind Method</term><term>Gastroenteritis (prevention & control)</term><term>Gastroenteritis (virology)</term><term>Humans</term><term>Immunization Schedule</term><term>Immunoglobulin A (blood)</term><term>Infant</term><term>Rotavirus (immunology)</term><term>Rotavirus Infections (immunology)</term><term>Rotavirus Infections (prevention & control)</term><term>Rotavirus Vaccines (administration & dosage)</term><term>Rotavirus Vaccines (immunology)</term><term>Severity of Illness Index</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term><term>Afrique subsaharienne</term><term>Anticorps antiviraux (sang)</term><term>Calendrier vaccinal</term><term>Gastroentérite ()</term><term>Gastroentérite (virologie)</term><term>Humains</term><term>Immunoglobuline A (sang)</term><term>Indice de gravité médicale</term><term>Infections à rotavirus ()</term><term>Infections à rotavirus (immunologie)</term><term>Méthode en double aveugle</term><term>Nourrisson</term><term>Pays en voie de développement</term><term>Rotavirus (immunologie)</term><term>Vaccins anti-rotavirus (administration et posologie)</term><term>Vaccins anti-rotavirus (immunologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Rotavirus Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Rotavirus Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Africa South of the Sahara</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins anti-rotavirus</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à rotavirus</term><term>Rotavirus</term><term>Vaccins anti-rotavirus</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Rotavirus</term><term>Rotavirus Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Gastroenteritis</term><term>Rotavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Gastroentérite</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Gastroenteritis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Developing Countries</term><term>Double-Blind Method</term><term>Humans</term><term>Immunization Schedule</term><term>Infant</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Afrique subsaharienne</term><term>Calendrier vaccinal</term><term>Gastroentérite</term><term>Humains</term><term>Indice de gravité médicale</term><term>Infections à rotavirus</term><term>Méthode en double aveugle</term><term>Nourrisson</term><term>Pays en voie de développement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa. Because rotavirus vaccines have proven effective in developed countries but had not been tested in developing countries, we assessed efficacy of a pentavalent rotavirus vaccine against severe disease in Ghana, Kenya, and Mali between April, 2007, and March, 2009.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20692030</PMID><DateCreated><Year>2010</Year><Month>08</Month><Day>23</Day></DateCreated><DateCompleted><Year>2010</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>376</Volume><Issue>9741</Issue><PubDate><Year>2010</Year><Month>Aug</Month><Day>21</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial.</ArticleTitle><Pagination><MedlinePgn>606-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(10)60889-6</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa. Because rotavirus vaccines have proven effective in developed countries but had not been tested in developing countries, we assessed efficacy of a pentavalent rotavirus vaccine against severe disease in Ghana, Kenya, and Mali between April, 2007, and March, 2009.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In our multicentre, double-blind, placebo-controlled trial, undertaken in rural areas of Ghana and Kenya and an urban area of Mali, we randomly assigned infants aged 4-12 weeks without symptoms of gastrointestinal disorders in a 1:1 ratio to receive three oral doses of pentavalent rotavirus vaccine 2 mL or placebo at around 6 weeks, 10 weeks, and 14 weeks of age. Infants with HIV infection were not excluded. Randomisation was done by computer-generated randomisation sequence in blocks of six. We obtained data for gastrointestinal symptoms from parents on presentation to health-care facilities and clinical data were obtained prospectively by clinicians. The primary endpoint was severe rotavirus gastroenteritis (Vesikari score >or=11), detected by enzyme immunoassay, arising 14 days or more after the third dose of placebo or vaccine to end of study (March 31, 2009; around 21 months of age). Analysis was per protocol; infants who received scheduled doses of vaccine or placebo without intervening laboratory-confirmed naturally occurring rotavirus disease earlier than 14 days after the third dose and had complete clinical and laboratory results were included in the analysis. This study is registered with ClinicalTrials.gov, number NCT00362648.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">5468 infants were randomly assigned to receive pentavalent rotavirus vaccine (n=2733) or placebo (n=2735). 2357 infants assigned to vaccine and 2348 assigned to placebo were included in the per-protocol analysis. 79 cases of severe rotavirus gastroenteritis were reported in 2610.6 person-years in the vaccine group, compared with 129 cases in 2585.9 person-years in the placebo group, resulting in a vaccine efficacy against severe rotavirus gastroenteritis of 39.3% (95% CI 19.1-54.7, p=0.0003 for efficacy >0%). Median follow-up in both groups was 527 days starting 14 days after the third dose of vaccine or placebo was given. 42 (1.5%) of 2723 infants assigned to receive vaccine and 45 (1.7%) of 2724 infants assigned to receive placebo had a serious adverse event within 14 days of any dose. The most frequent serious adverse event was gastroenteritis (vaccine 17 [0.6%]; placebo 17 [0.6%]).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Pentavalent rotavirus vaccine is effective against severe rotavirus gastroenteritis in the first 2 years of life in African countries with high mortality in infants younger than 5 years. We support WHO's recommendation for adoption of rotavirus vaccine into national expanded programmes on immunisation in Africa.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">PATH (GAVI Alliance grant) and Merck.</AbstractText><CopyrightInformation>Copyright 2010 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Armah</LastName><ForeName>George E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sow</LastName><ForeName>Samba O</ForeName><Initials>SO</Initials></Author><Author ValidYN="Y"><LastName>Breiman</LastName><ForeName>Robert F</ForeName><Initials>RF</Initials></Author><Author ValidYN="Y"><LastName>Dallas</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Tapia</LastName><ForeName>Milagritos D</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Feikin</LastName><ForeName>Daniel R</ForeName><Initials>DR</Initials></Author><Author ValidYN="Y"><LastName>Binka</LastName><ForeName>Fred N</ForeName><Initials>FN</Initials></Author><Author ValidYN="Y"><LastName>Steele</LastName><ForeName>A Duncan</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Laserson</LastName><ForeName>Kayla F</ForeName><Initials>KF</Initials></Author><Author ValidYN="Y"><LastName>Ansah</LastName><ForeName>Nana A</ForeName><Initials>NA</Initials></Author><Author ValidYN="Y"><LastName>Levine</LastName><ForeName>Myron M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>Kristen</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Coia</LastName><ForeName>Michele L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Attah-Poku</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ojwando</LastName><ForeName>Joel</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Rivers</LastName><ForeName>Stephen B</ForeName><Initials>SB</Initials></Author><Author ValidYN="Y"><LastName>Victor</LastName><ForeName>John C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Nyambane</LastName><ForeName>Geoffrey</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Hodgson</LastName><ForeName>Abraham</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Schödel</LastName><ForeName>Florian</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Ciarlet</LastName><ForeName>Max</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Neuzil</LastName><ForeName>Kathleen M</ForeName><Initials>KM</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00362648</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>08</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C492535">RotaTeq</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D022243">Rotavirus Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2010 Dec 4;376(9756):1897; author reply 1898</RefSource><PMID Version="1">21130280</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2010 Aug 21;376(9741):568-70</RefSource><PMID Version="1">20692032</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2010 Dec 4;376(9756):1897; author reply 1898</RefSource><PMID Version="1">21130281</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017954" MajorTopicYN="N" Type="Geographic">Africa South of the Sahara</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003906" MajorTopicYN="Y">Developing Countries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005759" MajorTopicYN="N">Gastroenteritis</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007115" MajorTopicYN="N">Immunization Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012401" MajorTopicYN="N">Rotavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012400" MajorTopicYN="N">Rotavirus Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D022243" MajorTopicYN="N">Rotavirus Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20692030</ArticleId><ArticleId IdType="pii">S0140-6736(10)60889-6</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(10)60889-6</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><noCountry><name sortKey="Ansah, Nana A" sort="Ansah, Nana A" uniqKey="Ansah N" first="Nana A" last="Ansah">Nana A. Ansah</name><name sortKey="Attah Poku, Margaret" sort="Attah Poku, Margaret" uniqKey="Attah Poku M" first="Margaret" last="Attah-Poku">Margaret Attah-Poku</name><name sortKey="Binka, Fred N" sort="Binka, Fred N" uniqKey="Binka F" first="Fred N" last="Binka">Fred N. Binka</name><name sortKey="Breiman, Robert F" sort="Breiman, Robert F" uniqKey="Breiman R" first="Robert F" last="Breiman">Robert F. Breiman</name><name sortKey="Ciarlet, Max" sort="Ciarlet, Max" uniqKey="Ciarlet M" first="Max" last="Ciarlet">Max Ciarlet</name><name sortKey="Coia, Michele L" sort="Coia, Michele L" uniqKey="Coia M" first="Michele L" last="Coia">Michele L. Coia</name><name sortKey="Dallas, Michael J" sort="Dallas, Michael J" uniqKey="Dallas M" first="Michael J" last="Dallas">Michael J. Dallas</name><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R" last="Feikin">Daniel R. Feikin</name><name sortKey="Hodgson, Abraham" sort="Hodgson, Abraham" uniqKey="Hodgson A" first="Abraham" last="Hodgson">Abraham Hodgson</name><name sortKey="Laserson, Kayla F" sort="Laserson, Kayla F" uniqKey="Laserson K" first="Kayla F" last="Laserson">Kayla F. Laserson</name><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M" last="Levine">Myron M. Levine</name><name sortKey="Lewis, Kristen" sort="Lewis, Kristen" uniqKey="Lewis K" first="Kristen" last="Lewis">Kristen Lewis</name><name sortKey="Neuzil, Kathleen M" sort="Neuzil, Kathleen M" uniqKey="Neuzil K" first="Kathleen M" last="Neuzil">Kathleen M. Neuzil</name><name sortKey="Nyambane, Geoffrey" sort="Nyambane, Geoffrey" uniqKey="Nyambane G" first="Geoffrey" last="Nyambane">Geoffrey Nyambane</name><name sortKey="Ojwando, Joel" sort="Ojwando, Joel" uniqKey="Ojwando J" first="Joel" last="Ojwando">Joel Ojwando</name><name sortKey="Rivers, Stephen B" sort="Rivers, Stephen B" uniqKey="Rivers S" first="Stephen B" last="Rivers">Stephen B. Rivers</name><name sortKey="Schodel, Florian" sort="Schodel, Florian" uniqKey="Schodel F" first="Florian" last="Schödel">Florian Schödel</name><name sortKey="Sow, Samba O" sort="Sow, Samba O" uniqKey="Sow S" first="Samba O" last="Sow">Samba O. Sow</name><name sortKey="Steele, A Duncan" sort="Steele, A Duncan" uniqKey="Steele A" first="A Duncan" last="Steele">A Duncan Steele</name><name sortKey="Tapia, Milagritos D" sort="Tapia, Milagritos D" uniqKey="Tapia M" first="Milagritos D" last="Tapia">Milagritos D. Tapia</name><name sortKey="Victor, John C" sort="Victor, John C" uniqKey="Victor J" first="John C" last="Victor">John C. Victor</name></noCountry><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Armah, George E" sort="Armah, George E" uniqKey="Armah G" first="George E" last="Armah">George E. Armah</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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