SidaGhanaV1, Pmc, Corpus, bibRecord, 000307

The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana

Identifieur interne : 000307 ( Pmc/Corpus ); précédent : 000306; suivant : 000308

The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana

Auteurs : George Asumeng Koffuor ; Rita Dickson ; Stephen Yao Gbedema ; Edmund Ekuadzi ; Gabriel Dapaah ; Lydia Francisca Otoo

Source :

African Journal of Traditional, Complementary, and Alternative Medicines [ 0189-6016 ] ; 2014.

RBID : PMC:4202435

Abstract

Background

HIV/AIDS is a pandemic retarding economic growth and destroying human capital globally. This study therefore investigated the perceived efficacy of Betula alba (BA) and Sutherlandia frutescens (SF) decoctions used in the management of HIV/AIDS in Ghana.

Materials and Methods

A study on the records of HIV/AIDS patients attending Habibi Herbal Clinic, Kumasi, Ghana, was conducted to obtain information on the initial viral load presented during their maiden visit and results after treatment with the herbal decoctions. The decoctions were assessed for immunostimulatory property in cyclophosphamide-induced immunosuppressed ICR mice. Total white blood cell count, as well as lymphocyte and neutrophil counts were determined and their effects compared with Levamisole. The decoctions were also screened for antimicrobial activity by the micro dilution method.

Results

The two herbal decoctions used significantly reduced (P ≤ 0.001) the patients' viral loads (47.42 ± 17.28 % to 13.69 ± 12.42 %; n=16). BA (1, 2, and 4 mg/kg) and SF (0.4, 0.8, and 1.6 mg/kg) caused significant increment (P ≤ 0.001) in total WBC and lymphocyte count in mice comparable to that produced by 2.5 mg/kg Levamisole. The decoctions also exhibited antimicrobial activity against gram negative and gram positive bacteria as well as Candida albicans (MIC 0.607 to 3.062 mg/ml). Phytochemicals present in both plants include saponins, terpenoids and coumarins.

Conclusion

The Betula alba and Sutherlandia frutescens decoctions have interesting immunostimulatory and antimicrobial properties and hence could be useful in the management of HIV/AIDS and associated opportunistic infections.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202435

PubMed: 25371579
PubMed Central: 4202435

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PMC:4202435

Le document en format XML

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<author><name sortKey="Koffuor, George Asumeng" sort="Koffuor, George Asumeng" uniqKey="Koffuor G" first="George Asumeng" last="Koffuor">George Asumeng Koffuor</name>
<affiliation><nlm:aff id="A1">Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dickson, Rita" sort="Dickson, Rita" uniqKey="Dickson R" first="Rita" last="Dickson">Rita Dickson</name>
<affiliation><nlm:aff id="A2">Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gbedema, Stephen Yao" sort="Gbedema, Stephen Yao" uniqKey="Gbedema S" first="Stephen Yao" last="Gbedema">Stephen Yao Gbedema</name>
<affiliation><nlm:aff id="A3">Department of Pharmaceutics; Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ekuadzi, Edmund" sort="Ekuadzi, Edmund" uniqKey="Ekuadzi E" first="Edmund" last="Ekuadzi">Edmund Ekuadzi</name>
<affiliation><nlm:aff id="A2">Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dapaah, Gabriel" sort="Dapaah, Gabriel" uniqKey="Dapaah G" first="Gabriel" last="Dapaah">Gabriel Dapaah</name>
<affiliation><nlm:aff id="A1">Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
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<author><name sortKey="Otoo, Lydia Francisca" sort="Otoo, Lydia Francisca" uniqKey="Otoo L" first="Lydia Francisca" last="Otoo">Lydia Francisca Otoo</name>
<affiliation><nlm:aff id="A1">Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana</title>
<author><name sortKey="Koffuor, George Asumeng" sort="Koffuor, George Asumeng" uniqKey="Koffuor G" first="George Asumeng" last="Koffuor">George Asumeng Koffuor</name>
<affiliation><nlm:aff id="A1">Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dickson, Rita" sort="Dickson, Rita" uniqKey="Dickson R" first="Rita" last="Dickson">Rita Dickson</name>
<affiliation><nlm:aff id="A2">Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gbedema, Stephen Yao" sort="Gbedema, Stephen Yao" uniqKey="Gbedema S" first="Stephen Yao" last="Gbedema">Stephen Yao Gbedema</name>
<affiliation><nlm:aff id="A3">Department of Pharmaceutics; Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ekuadzi, Edmund" sort="Ekuadzi, Edmund" uniqKey="Ekuadzi E" first="Edmund" last="Ekuadzi">Edmund Ekuadzi</name>
<affiliation><nlm:aff id="A2">Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dapaah, Gabriel" sort="Dapaah, Gabriel" uniqKey="Dapaah G" first="Gabriel" last="Dapaah">Gabriel Dapaah</name>
<affiliation><nlm:aff id="A1">Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Otoo, Lydia Francisca" sort="Otoo, Lydia Francisca" uniqKey="Otoo L" first="Lydia Francisca" last="Otoo">Lydia Francisca Otoo</name>
<affiliation><nlm:aff id="A1">Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">African Journal of Traditional, Complementary, and Alternative Medicines</title>
<idno type="eISSN">0189-6016</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>HIV/AIDS is a pandemic retarding economic growth and destroying human capital globally. This study therefore investigated the perceived efficacy of <italic>Betula alba</italic>
 (BA) and <italic>Sutherlandia frutescens</italic>
 (SF) decoctions used in the management of HIV/AIDS in Ghana.</p>
</sec>
<sec sec-type="materials|methods"><title>Materials and Methods</title>
<p>A study on the records of HIV/AIDS patients attending Habibi Herbal Clinic, Kumasi, Ghana, was conducted to obtain information on the initial viral load presented during their maiden visit and results after treatment with the herbal decoctions. The decoctions were assessed for immunostimulatory property in cyclophosphamide-induced immunosuppressed ICR mice. Total white blood cell count, as well as lymphocyte and neutrophil counts were determined and their effects compared with Levamisole. The decoctions were also screened for antimicrobial activity by the micro dilution method.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>The two herbal decoctions used significantly reduced (P ≤ 0.001) the patients' viral loads (47.42 ± 17.28 % to 13.69 ± 12.42 %; n=16). BA (1, 2, and 4 mg/kg) and SF (0.4, 0.8, and 1.6 mg/kg) caused significant increment (P ≤ 0.001) in total WBC and lymphocyte count in mice comparable to that produced by 2.5 mg/kg Levamisole. The decoctions also exhibited antimicrobial activity against gram negative and gram positive bacteria as well as <italic>Candida albicans</italic>
 (MIC 0.607 to 3.062 mg/ml). Phytochemicals present in both plants include saponins, terpenoids and coumarins.</p>
</sec>
<sec sec-type="conclusions"><title>Conclusion</title>
<p>The <italic>Betula alba</italic>
 and <italic>Sutherlandia frutescens</italic>
 decoctions have interesting immunostimulatory and antimicrobial properties and hence could be useful in the management of HIV/AIDS and associated opportunistic infections.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Afr J Tradit Complement Altern Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Afr J Tradit Complement Altern Med</journal-id>
<journal-title-group><journal-title>African Journal of Traditional, Complementary, and Alternative Medicines</journal-title>
</journal-title-group>
<issn pub-type="epub">0189-6016</issn>
<publisher><publisher-name>African Networks on Ethnomedicines</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25371579</article-id>
<article-id pub-id-type="pmc">4202435</article-id>
<article-id pub-id-type="publisher-id">jAJT.v11.i3.pg166</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Koffuor</surname>
<given-names>George Asumeng</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dickson</surname>
<given-names>Rita</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gbedema</surname>
<given-names>Stephen Yao</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ekuadzi</surname>
<given-names>Edmund</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dapaah</surname>
<given-names>Gabriel</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Otoo</surname>
<given-names>Lydia Francisca</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</aff>
<aff id="A2"><label>2</label>
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</aff>
<aff id="A3"><label>3</label>
Department of Pharmaceutics; Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</aff>
<author-notes><corresp><email>gkoffuor@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>3</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>11</volume>
<issue>3</issue>
<fpage>166</fpage>
<lpage>172</lpage>
<permissions><copyright-statement>Copyright © Afr. J. Traditional Complementary and Alternative Medicines 2014</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract abstract-type="executive-summary"><sec><title>Background</title>
<p>HIV/AIDS is a pandemic retarding economic growth and destroying human capital globally. This study therefore investigated the perceived efficacy of <italic>Betula alba</italic>
 (BA) and <italic>Sutherlandia frutescens</italic>
 (SF) decoctions used in the management of HIV/AIDS in Ghana.</p>
</sec>
<sec sec-type="materials|methods"><title>Materials and Methods</title>
<p>A study on the records of HIV/AIDS patients attending Habibi Herbal Clinic, Kumasi, Ghana, was conducted to obtain information on the initial viral load presented during their maiden visit and results after treatment with the herbal decoctions. The decoctions were assessed for immunostimulatory property in cyclophosphamide-induced immunosuppressed ICR mice. Total white blood cell count, as well as lymphocyte and neutrophil counts were determined and their effects compared with Levamisole. The decoctions were also screened for antimicrobial activity by the micro dilution method.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>The two herbal decoctions used significantly reduced (P ≤ 0.001) the patients' viral loads (47.42 ± 17.28 % to 13.69 ± 12.42 %; n=16). BA (1, 2, and 4 mg/kg) and SF (0.4, 0.8, and 1.6 mg/kg) caused significant increment (P ≤ 0.001) in total WBC and lymphocyte count in mice comparable to that produced by 2.5 mg/kg Levamisole. The decoctions also exhibited antimicrobial activity against gram negative and gram positive bacteria as well as <italic>Candida albicans</italic>
 (MIC 0.607 to 3.062 mg/ml). Phytochemicals present in both plants include saponins, terpenoids and coumarins.</p>
</sec>
<sec sec-type="conclusions"><title>Conclusion</title>
<p>The <italic>Betula alba</italic>
 and <italic>Sutherlandia frutescens</italic>
 decoctions have interesting immunostimulatory and antimicrobial properties and hence could be useful in the management of HIV/AIDS and associated opportunistic infections.</p>
</sec>
</abstract>
<kwd-group><kwd><italic>Betula alba</italic>
</kwd>
<kwd><italic>Sutherlandia frutescen,s</italic>
</kwd>
<kwd>Viral load</kwd>
<kwd>Minimum inhibitory concentration</kwd>
<kwd>Micro-well dilution assay</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana

The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana

Source :

Abstract

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