Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.
Identifieur interne : 000257 ( Ncbi/Merge ); précédent : 000256; suivant : 000258Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.
Auteurs : Kwamena William Coleman Sagoe [Ghana] ; Magdar Dwidar ; Margaret Lartey [Ghana] ; Isaac Boamah ; Afrakoma Adjoa Agyei ; Anna Aba Hayford ; Julius Abraham Addo Mingle ; Max Q. ArensSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1386-6532 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (pharmacologie), Attribution aléatoire, Ghana, Gènes viraux, Humains, Infections à VIH (virologie), Mutation, Phylogénie, Protéase du VIH (génétique), Résistance virale aux médicaments, Transcriptase inverse du VIH (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), Variation génétique.
- MESH :
- génétique : Protéase du VIH, Transcriptase inverse du VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- pharmacologie : Agents antiVIH.
- virologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Attribution aléatoire, Ghana, Gènes viraux, Humains, Mutation, Phylogénie, Résistance virale aux médicaments, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Variation génétique.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HIV Protease, HIV Reverse Transcriptase.
- chemical , pharmacology : Anti-HIV Agents.
- geographic : Ghana.
- drug effects : HIV-1.
- genetics : HIV-1.
- virology : HIV Infections.
- Adult, Drug Resistance, Viral, Genes, Viral, Genetic Variation, Humans, Middle Aged, Mutation, Phylogeny, Random Allocation.
Abstract
Little is known about the HIV-1 drug resistance mutations in Ghana.
DOI: 10.1016/j.jcv.2007.07.016
PubMed: 17827059
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- to stream PubMed, to step Corpus: 000246
- to stream PubMed, to step Curation: 000246
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pubmed:17827059Le document en format XML
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<series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title>
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<term>Anti-HIV Agents (pharmacology)</term>
<term>Drug Resistance, Viral</term>
<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Ghana</term>
<term>HIV Infections (virology)</term>
<term>HIV Protease (genetics)</term>
<term>HIV Reverse Transcriptase (genetics)</term>
<term>HIV-1 (drug effects)</term>
<term>HIV-1 (genetics)</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Phylogeny</term>
<term>Random Allocation</term>
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<term>Adulte d'âge moyen</term>
<term>Agents antiVIH (pharmacologie)</term>
<term>Attribution aléatoire</term>
<term>Ghana</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Infections à VIH (virologie)</term>
<term>Mutation</term>
<term>Phylogénie</term>
<term>Protéase du VIH (génétique)</term>
<term>Résistance virale aux médicaments</term>
<term>Transcriptase inverse du VIH (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
<term>Variation génétique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HIV Protease</term>
<term>HIV Reverse Transcriptase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéase du VIH</term>
<term>Transcriptase inverse du VIH</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Drug Resistance, Viral</term>
<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Phylogeny</term>
<term>Random Allocation</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Attribution aléatoire</term>
<term>Ghana</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Mutation</term>
<term>Phylogénie</term>
<term>Résistance virale aux médicaments</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Variation génétique</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
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<front><div type="abstract" xml:lang="en">Little is known about the HIV-1 drug resistance mutations in Ghana.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17827059</PMID>
<DateCreated><Year>2007</Year>
<Month>09</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted><Year>2007</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2008</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1386-6532</ISSN>
<JournalIssue CitedMedium="Print"><Volume>40</Volume>
<Issue>2</Issue>
<PubDate><Year>2007</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title>
<ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.</ArticleTitle>
<Pagination><MedlinePgn>163-7</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Little is known about the HIV-1 drug resistance mutations in Ghana.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine the background protease (PR) and reverse transcriptase (RT) mutations of HIV-1 from treatment naïve patients in Ghana.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Twenty-five plasma samples randomly selected were analyzed for drug resistance mutations. The molecular phylogeny and recombinant patterns of the polymerase gene of HIV-1 were also analysed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">No major drug-resistance mutations were seen in protease or reverse transcriptase genes. The L10I, L10V, V11I and E35G minor mutations were seen in four patients, while the V179E was observed in a patient with subtype G. An insertion of lysine was found at codon 36 of the protease gene of one patient. The predominant subtype was the CRF02_AG strain (n=22), but 3 (13.6%) of these were recombinants with HIV-1 subtype K and/or A1. Two patients harboured unclassified/complex strains with D/CRF01_AE and G/CRFAG_02 subtypes for the PR and RT, respectively, using the Stanford Database. Viral loads (VL) ranged from 2290 to >1,500,000c/ml (mean=339,065c/ml).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Treatment naïve patients in Ghana before scale-up may have minor but not major PR mutations and high viral loads. The clinical effects of minor mutations/polymorphisms in the PR and RT genes and recombinants need to be investigated.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sagoe</LastName>
<ForeName>Kwamena William Coleman</ForeName>
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<Author ValidYN="Y"><LastName>Dwidar</LastName>
<ForeName>Magdar</ForeName>
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<Author ValidYN="Y"><LastName>Lartey</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Boamah</LastName>
<ForeName>Isaac</ForeName>
<Initials>I</Initials>
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<Author ValidYN="Y"><LastName>Agyei</LastName>
<ForeName>Afrakoma Adjoa</ForeName>
<Initials>AA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hayford</LastName>
<ForeName>Anna Aba</ForeName>
<Initials>AA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mingle</LastName>
<ForeName>Julius Abraham Addo</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Arens</LastName>
<ForeName>Max Q</ForeName>
<Initials>MQ</Initials>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<Month>09</Month>
<Day>10</Day>
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<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Clin Virol</MedlineTA>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.7.49</RegistryNumber>
<NameOfSubstance UI="D054303">HIV Reverse Transcriptase</NameOfSubstance>
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<Chemical><RegistryNumber>EC 3.4.23.-</RegistryNumber>
<NameOfSubstance UI="D016333">HIV Protease</NameOfSubstance>
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<MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName>
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<MeshHeading><DescriptorName UI="D005814" MajorTopicYN="Y">Genes, Viral</DescriptorName>
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<MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName>
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<MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName>
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<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
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<MeshHeading><DescriptorName UI="D054303" MajorTopicYN="N">HIV Reverse Transcriptase</DescriptorName>
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<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
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<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
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<MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName>
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<name sortKey="Arens, Max Q" sort="Arens, Max Q" uniqKey="Arens M" first="Max Q" last="Arens">Max Q. Arens</name>
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<name sortKey="Hayford, Anna Aba" sort="Hayford, Anna Aba" uniqKey="Hayford A" first="Anna Aba" last="Hayford">Anna Aba Hayford</name>
<name sortKey="Mingle, Julius Abraham Addo" sort="Mingle, Julius Abraham Addo" uniqKey="Mingle J" first="Julius Abraham Addo" last="Mingle">Julius Abraham Addo Mingle</name>
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