Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.
Identifieur interne : 000246 ( PubMed/Curation ); précédent : 000245; suivant : 000247Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.
Auteurs : Kwamena William Coleman Sagoe [Ghana] ; Magdar Dwidar ; Margaret Lartey ; Isaac Boamah ; Afrakoma Adjoa Agyei ; Anna Aba Hayford ; Julius Abraham Addo Mingle ; Max Q. ArensSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1386-6532 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (pharmacologie), Attribution aléatoire, Ghana, Gènes viraux, Humains, Infections à VIH (virologie), Mutation, Phylogénie, Protéase du VIH (génétique), Résistance virale aux médicaments, Transcriptase inverse du VIH (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), Variation génétique.
- MESH :
- génétique : Protéase du VIH, Transcriptase inverse du VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- pharmacologie : Agents antiVIH.
- virologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Attribution aléatoire, Ghana, Gènes viraux, Humains, Mutation, Phylogénie, Résistance virale aux médicaments, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Variation génétique.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HIV Protease, HIV Reverse Transcriptase.
- chemical , pharmacology : Anti-HIV Agents.
- geographic : Ghana.
- drug effects : HIV-1.
- genetics : HIV-1.
- virology : HIV Infections.
- Adult, Drug Resistance, Viral, Genes, Viral, Genetic Variation, Humans, Middle Aged, Mutation, Phylogeny, Random Allocation.
Abstract
Little is known about the HIV-1 drug resistance mutations in Ghana.
DOI: 10.1016/j.jcv.2007.07.016
PubMed: 17827059
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Arens</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17827059</idno><idno type="pmid">17827059</idno><idno type="doi">10.1016/j.jcv.2007.07.016</idno><idno type="wicri:Area/PubMed/Corpus">000246</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000246</idno><idno type="wicri:Area/PubMed/Curation">000246</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000246</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.</title><author><name sortKey="Sagoe, Kwamena William Coleman" sort="Sagoe, Kwamena William Coleman" uniqKey="Sagoe K" first="Kwamena William Coleman" last="Sagoe">Kwamena William Coleman Sagoe</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Virology Laboratory (Department of Microbiology), University of Ghana Medical School, Accra, Ghana. kwcsagoe@chs.edu.ug</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Clinical Virology Laboratory (Department of Microbiology), University of Ghana Medical School, Accra</wicri:regionArea></affiliation></author><author><name sortKey="Dwidar, Magdar" sort="Dwidar, Magdar" uniqKey="Dwidar M" first="Magdar" last="Dwidar">Magdar Dwidar</name></author><author><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name></author><author><name sortKey="Boamah, Isaac" sort="Boamah, Isaac" uniqKey="Boamah I" first="Isaac" last="Boamah">Isaac Boamah</name></author><author><name sortKey="Agyei, Afrakoma Adjoa" sort="Agyei, Afrakoma Adjoa" uniqKey="Agyei A" first="Afrakoma Adjoa" last="Agyei">Afrakoma Adjoa Agyei</name></author><author><name sortKey="Hayford, Anna Aba" sort="Hayford, Anna Aba" uniqKey="Hayford A" first="Anna Aba" last="Hayford">Anna Aba Hayford</name></author><author><name sortKey="Mingle, Julius Abraham Addo" sort="Mingle, Julius Abraham Addo" uniqKey="Mingle J" first="Julius Abraham Addo" last="Mingle">Julius Abraham Addo Mingle</name></author><author><name sortKey="Arens, Max Q" sort="Arens, Max Q" uniqKey="Arens M" first="Max Q" last="Arens">Max Q. Arens</name></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="ISSN">1386-6532</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-HIV Agents (pharmacology)</term><term>Drug Resistance, Viral</term><term>Genes, Viral</term><term>Genetic Variation</term><term>Ghana</term><term>HIV Infections (virology)</term><term>HIV Protease (genetics)</term><term>HIV Reverse Transcriptase (genetics)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (genetics)</term><term>Humans</term><term>Middle Aged</term><term>Mutation</term><term>Phylogeny</term><term>Random Allocation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (pharmacologie)</term><term>Attribution aléatoire</term><term>Ghana</term><term>Gènes viraux</term><term>Humains</term><term>Infections à VIH (virologie)</term><term>Mutation</term><term>Phylogénie</term><term>Protéase du VIH (génétique)</term><term>Résistance virale aux médicaments</term><term>Transcriptase inverse du VIH (génétique)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HIV Protease</term><term>HIV Reverse Transcriptase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéase du VIH</term><term>Transcriptase inverse du VIH</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Drug Resistance, Viral</term><term>Genes, Viral</term><term>Genetic Variation</term><term>Humans</term><term>Middle Aged</term><term>Mutation</term><term>Phylogeny</term><term>Random Allocation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Attribution aléatoire</term><term>Ghana</term><term>Gènes viraux</term><term>Humains</term><term>Mutation</term><term>Phylogénie</term><term>Résistance virale aux médicaments</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Little is known about the HIV-1 drug resistance mutations in Ghana.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17827059</PMID><DateCreated><Year>2007</Year><Month>09</Month><Day>24</Day></DateCreated><DateCompleted><Year>2007</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1386-6532</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation></Journal><ArticleTitle>Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naïve patients in Accra, Ghana.</ArticleTitle><Pagination><MedlinePgn>163-7</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Little is known about the HIV-1 drug resistance mutations in Ghana.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine the background protease (PR) and reverse transcriptase (RT) mutations of HIV-1 from treatment naïve patients in Ghana.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Twenty-five plasma samples randomly selected were analyzed for drug resistance mutations. The molecular phylogeny and recombinant patterns of the polymerase gene of HIV-1 were also analysed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">No major drug-resistance mutations were seen in protease or reverse transcriptase genes. The L10I, L10V, V11I and E35G minor mutations were seen in four patients, while the V179E was observed in a patient with subtype G. An insertion of lysine was found at codon 36 of the protease gene of one patient. The predominant subtype was the CRF02_AG strain (n=22), but 3 (13.6%) of these were recombinants with HIV-1 subtype K and/or A1. Two patients harboured unclassified/complex strains with D/CRF01_AE and G/CRFAG_02 subtypes for the PR and RT, respectively, using the Stanford Database. Viral loads (VL) ranged from 2290 to >1,500,000c/ml (mean=339,065c/ml).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Treatment naïve patients in Ghana before scale-up may have minor but not major PR mutations and high viral loads. The clinical effects of minor mutations/polymorphisms in the PR and RT genes and recombinants need to be investigated.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sagoe</LastName><ForeName>Kwamena William Coleman</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Clinical Virology Laboratory (Department of Microbiology), University of Ghana Medical School, Accra, Ghana. kwcsagoe@chs.edu.ug</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dwidar</LastName><ForeName>Magdar</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lartey</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Boamah</LastName><ForeName>Isaac</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Agyei</LastName><ForeName>Afrakoma Adjoa</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Hayford</LastName><ForeName>Anna Aba</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Mingle</LastName><ForeName>Julius Abraham Addo</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Arens</LastName><ForeName>Max Q</ForeName><Initials>MQ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.49</RegistryNumber><NameOfSubstance UI="D054303">HIV Reverse Transcriptase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.23.-</RegistryNumber><NameOfSubstance UI="D016333">HIV Protease</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005814" MajorTopicYN="Y">Genes, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016333" MajorTopicYN="N">HIV Protease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054303" MajorTopicYN="N">HIV Reverse Transcriptase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>04</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2007</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>07</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>9</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>12</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>9</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17827059</ArticleId><ArticleId IdType="pii">S1386-6532(07)00262-4</ArticleId><ArticleId IdType="doi">10.1016/j.jcv.2007.07.016</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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