HIV-1 proteases from drug-naive West African patients are differentially less susceptible to protease inhibitors.
Identifieur interne : 000174 ( Ncbi/Checkpoint ); précédent : 000173; suivant : 000175HIV-1 proteases from drug-naive West African patients are differentially less susceptible to protease inhibitors.
Auteurs : Masanobu Kinomoto [Japon] ; Regina Appiah-Opong ; J A M. Brandful ; Masaru Yokoyama ; Nicholas Nii-Trebi ; Evelyn Ugly-Kwame ; Hironori Sato ; David Ofori-Adjei ; Takeshi Kurata ; Françoise Barre-Sinoussi ; Tetsutaro Sata ; Kenzo TokunagaSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Alignement de séquences, Conformation des protéines, Données de séquences moléculaires, Ghana (épidémiologie), Humains, Infections à VIH (virologie), Inhibiteurs de protéase du VIH (pharmacologie), Multirésistance virale aux médicaments, Phylogénie, Protéase du VIH (), Protéase du VIH (métabolisme), Séquence d'acides aminés, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (enzymologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique).
- MESH :
- enzymologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- génétique : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- métabolisme : Protéase du VIH.
- pharmacologie : Inhibiteurs de protéase du VIH.
- virologie : Infections à VIH.
- épidémiologie : Ghana.
- Adulte, Alignement de séquences, Conformation des protéines, Données de séquences moléculaires, Humains, Multirésistance virale aux médicaments, Phylogénie, Protéase du VIH, Séquence d'acides aminés.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Amino Acid Sequence, Drug Resistance, Multiple, Viral, Ghana (epidemiology), HIV Infections (virology), HIV Protease (chemistry), HIV Protease (metabolism), HIV Protease Inhibitors (pharmacology), HIV-1 (enzymology), HIV-1 (genetics), Humans, Molecular Sequence Data, Phylogeny, Protein Conformation, Sequence Alignment.
- MESH :
- chemical , chemistry : HIV Protease.
- geographic , epidemiology : Ghana.
- chemical , metabolism : HIV Protease.
- chemical , pharmacology : HIV Protease Inhibitors.
- enzymology : HIV-1.
- genetics : HIV-1.
- virology : HIV Infections.
- Adult, Amino Acid Sequence, Drug Resistance, Multiple, Viral, Humans, Molecular Sequence Data, Phylogeny, Protein Conformation, Sequence Alignment.
Abstract
Now that highly active antiretroviral therapy (HAART) is being initiated on a large scale in West Africa, it remains controversial whether protease inhibitors (PIs), originally designed and tested against human immunodeficiency virus type 1 (HIV-1) subtype B, are equally effective against the non-B subtypes that are prevalent in West African countries. In this study, we investigated whether Ghanaian HIV-1 isolates, as representatives of West African isolates, are susceptible to PIs.
DOI: 10.1086/431197
PubMed: 15983923
Affiliations:
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pubmed:15983923Le document en format XML
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du VIH</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Now that highly active antiretroviral therapy (HAART) is being initiated on a large scale in West Africa, it remains controversial whether protease inhibitors (PIs), originally designed and tested against human immunodeficiency virus type 1 (HIV-1) subtype B, are equally effective against the non-B subtypes that are prevalent in West African countries. In this study, we investigated whether Ghanaian HIV-1 isolates, as representatives of West African isolates, are susceptible to PIs.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Appiah Opong, Regina" sort="Appiah Opong, Regina" uniqKey="Appiah Opong R" first="Regina" last="Appiah-Opong">Regina Appiah-Opong</name><name sortKey="Barre Sinoussi, Francoise" sort="Barre Sinoussi, Francoise" uniqKey="Barre Sinoussi F" first="Françoise" last="Barre-Sinoussi">Françoise Barre-Sinoussi</name><name sortKey="Brandful, J A M" sort="Brandful, J A M" uniqKey="Brandful J" first="J A M" last="Brandful">J A M. Brandful</name><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name><name sortKey="Nii Trebi, Nicholas" sort="Nii Trebi, Nicholas" uniqKey="Nii Trebi N" first="Nicholas" last="Nii-Trebi">Nicholas Nii-Trebi</name><name sortKey="Ofori Adjei, David" sort="Ofori Adjei, David" uniqKey="Ofori Adjei D" first="David" last="Ofori-Adjei">David Ofori-Adjei</name><name sortKey="Sata, Tetsutaro" sort="Sata, Tetsutaro" uniqKey="Sata T" first="Tetsutaro" last="Sata">Tetsutaro Sata</name><name sortKey="Sato, Hironori" sort="Sato, Hironori" uniqKey="Sato H" first="Hironori" last="Sato">Hironori Sato</name><name sortKey="Tokunaga, Kenzo" sort="Tokunaga, Kenzo" uniqKey="Tokunaga K" first="Kenzo" last="Tokunaga">Kenzo Tokunaga</name><name sortKey="Ugly Kwame, Evelyn" sort="Ugly Kwame, Evelyn" uniqKey="Ugly Kwame E" first="Evelyn" last="Ugly-Kwame">Evelyn Ugly-Kwame</name><name sortKey="Yokoyama, Masaru" sort="Yokoyama, Masaru" uniqKey="Yokoyama M" first="Masaru" last="Yokoyama">Masaru Yokoyama</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Kinomoto, Masanobu" sort="Kinomoto, Masanobu" uniqKey="Kinomoto M" first="Masanobu" last="Kinomoto">Masanobu Kinomoto</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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