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Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany

Identifieur interne : 000881 ( Main/Exploration ); précédent : 000880; suivant : 000882

Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany

Auteurs : Markus Neibecker [Allemagne] ; Carolynne Schwarze-Zander [Allemagne] ; Jürgen K. Rockstroh [Allemagne] ; Ulrich Spengler [Allemagne] ; Jason T. Blackard [États-Unis]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2011-04.

RBID : ISTEX:EB2529154B667E683E8D54B84C26E72A2DCCACB4

English descriptors

KwdEn :
- Accession numbers, Bayesian, Bootstrap, Chronic hepatitis, Genome, Genotype, Genotype distribution, Hepatitis, Intergenotypic recombination, Limited number, Muerhoff, Novel genotype, Outlier, Outlier group, Phylogenetic, Phylogenetic analysis, Positive subjects, Recombinant, Recombination, Untranslated region, Virol.
Teeft :
- Accession numbers, Bayesian, Bootstrap, Chronic hepatitis, Genome, Genotype, Genotype distribution, Hepatitis, Intergenotypic recombination, Limited number, Muerhoff, Novel genotype, Outlier, Outlier group, Phylogenetic, Phylogenetic analysis, Positive subjects, Recombinant, Recombination, Untranslated region, Virol.

Abstract

Multiple genotypes of GB virus C (GBV‐C)—a non‐pathogenic flavivirus—have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV‐C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV‐C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV‐C RNA. Based on sequencing of the 5′ untranslated region (5′‐UTR), the GBV‐C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′‐UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV‐C. J. Med. Virol. 83:685–694, 2011. © 2011 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/document/EB2529154B667E683E8D54B84C26E72A2DCCACB4/fulltext/pdf

DOI: 10.1002/jmv.22029

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Multiple genotypes of GB virus C (GBV‐C)—a non‐pathogenic flavivirus—have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV‐C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV‐C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV‐C RNA. Based on sequencing of the 5′ untranslated region (5′‐UTR), the GBV‐C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′‐UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV‐C. J. Med. Virol. 83:685–694, 2011. © 2011 Wiley‐Liss, Inc.</div>
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Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany

Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri