Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany
Identifieur interne : 000913 ( Istex/Corpus ); précédent : 000912; suivant : 000914Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany
Auteurs : Markus Neibecker ; Carolynne Schwarze-Zander ; Jürgen K. Rockstroh ; Ulrich Spengler ; Jason T. BlackardSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2011-04.
English descriptors
- KwdEn :
- Accession numbers, Bayesian, Bootstrap, Chronic hepatitis, Genome, Genotype, Genotype distribution, Hepatitis, Intergenotypic recombination, Limited number, Muerhoff, Novel genotype, Outlier, Outlier group, Phylogenetic, Phylogenetic analysis, Positive subjects, Recombinant, Recombination, Untranslated region, Virol.
- Teeft :
- Accession numbers, Bayesian, Bootstrap, Chronic hepatitis, Genome, Genotype, Genotype distribution, Hepatitis, Intergenotypic recombination, Limited number, Muerhoff, Novel genotype, Outlier, Outlier group, Phylogenetic, Phylogenetic analysis, Positive subjects, Recombinant, Recombination, Untranslated region, Virol.
Abstract
Multiple genotypes of GB virus C (GBV‐C)—a non‐pathogenic flavivirus—have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV‐C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV‐C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV‐C RNA. Based on sequencing of the 5′ untranslated region (5′‐UTR), the GBV‐C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′‐UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV‐C. J. Med. Virol. 83:685–694, 2011. © 2011 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.22029
Links to Exploration step
ISTEX:EB2529154B667E683E8D54B84C26E72A2DCCACB4Le document en format XML
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Rockstroh</name><affiliations><json:string>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</json:string></affiliations></json:item><json:item><name>Ulrich Spengler</name><affiliations><json:string>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</json:string></affiliations></json:item><json:item><name>Jason T. Blackard</name><affiliations><json:string>Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio</json:string><json:string>Division of Digestive Diseases, University of Cincinnati College of Medicine, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267.===</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>GB virus C (GBV‐C) HIV</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diversity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genotype</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>recombination</value></json:item></subject><articleId><json:string>JMV22029</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Multiple genotypes of GB virus C (GBV‐C)—a non‐pathogenic flavivirus—have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV‐C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV‐C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV‐C RNA. Based on sequencing of the 5′ untranslated region (5′‐UTR), the GBV‐C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′‐UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV‐C. J. Med. 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type="first">Markus</forename><surname>Neibecker</surname></persName><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Carolynne</forename><surname>Schwarze‐Zander</surname></persName><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Jürgen K.</forename><surname>Rockstroh</surname></persName><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Ulrich</forename><surname>Spengler</surname></persName><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">Jason T.</forename><surname>Blackard</surname></persName><email>jason.blackard@uc.edu</email><affiliation>Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio<address><country key="US"></country></address></affiliation><affiliation>Division of Digestive Diseases, University of Cincinnati College of Medicine, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267.===</affiliation></author><idno type="istex">EB2529154B667E683E8D54B84C26E72A2DCCACB4</idno><idno type="DOI">10.1002/jmv.22029</idno><idno type="unit">JMV22029</idno><idno type="toTypesetVersion">file:JMV.JMV22029.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno 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Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley" registered="yes">10.1002/jmv.v83.4</doi><numberingGroup><numbering type="journalVolume" number="83">83</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2011-04">April 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="170" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jmv.22029</doi><idGroup><id type="unit" value="JMV22029"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title></titleGroup><copyright ownership="publisher">Copyright © 2011 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2010-11-15"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.6 mode:FullText" date="2011-02-15"></event><event type="firstOnline" date="2011-02-15"></event><event type="publishedOnlineFinalForm" date="2011-02-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">685</numbering><numbering type="pageLast">694</numbering></numberingGroup><correspondenceTo>Division of Digestive Diseases, University of Cincinnati College of Medicine, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267.===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV22029.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="4189"></count></countGroup><titleGroup><title type="main" xml:lang="en">Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany<link href="#fn1"></link></title><title type="short" xml:lang="en">GBV‐C Genotypes in Germany</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Markus</givenNames><familyName>Neibecker</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Carolynne</givenNames><familyName>Schwarze‐Zander</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jürgen K.</givenNames><familyName>Rockstroh</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ulrich</givenNames><familyName>Spengler</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Jason T.</givenNames><familyName>Blackard</familyName></personName><contactDetails><email>jason.blackard@uc.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">GB virus C (GBV‐C) HIV</keyword><keyword xml:id="kwd2">diversity</keyword><keyword xml:id="kwd3">genotype</keyword><keyword xml:id="kwd4">recombination</keyword></keywordGroup><fundingInfo><fundingAgency>H.W. & J. Hector Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NIH (to J.T.B.)</fundingAgency><fundingNumber>R21 AI081564</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Multiple genotypes of GB virus C (GBV‐C)—a non‐pathogenic flavivirus—have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV‐C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV‐C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV‐C RNA. Based on sequencing of the 5′ untranslated region (5′‐UTR), the GBV‐C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′‐UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV‐C. J. Med. Virol. 83:685–694, 2011. © 2011 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Markus Neibecker and Carolynne Schwarze‐Zander contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>GBV‐C Genotypes in Germany</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Evidence for extensive genotypic diversity and recombination of GB virus C (GBV‐C) in Germany</title></titleInfo><name type="personal"><namePart type="given">Markus</namePart><namePart type="family">Neibecker</namePart><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carolynne</namePart><namePart type="family">Schwarze‐Zander</namePart><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jürgen K.</namePart><namePart type="family">Rockstroh</namePart><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ulrich</namePart><namePart type="family">Spengler</namePart><affiliation>Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jason T.</namePart><namePart type="family">Blackard</namePart><affiliation>Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio</affiliation><affiliation>Division of Digestive Diseases, University of Cincinnati College of Medicine, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-04</dateIssued><dateValid encoding="w3cdtf">2010-11-15</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">35</extent><extent unit="words">4189</extent></physicalDescription><abstract lang="en">Multiple genotypes of GB virus C (GBV‐C)—a non‐pathogenic flavivirus—have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV‐C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV‐C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV‐C RNA. Based on sequencing of the 5′ untranslated region (5′‐UTR), the GBV‐C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′‐UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV‐C. J. Med. Virol. 83:685–694, 2011. © 2011 Wiley‐Liss, Inc.</abstract><note type="content">*Markus Neibecker and Carolynne Schwarze‐Zander contributed equally to this work.</note><note type="funding">H.W. & J. Hector Foundation</note><note type="funding">NIH (to J.T.B.) - No. R21 AI081564; </note><subject lang="en"><genre>keywords</genre><topic>GB virus C (GBV‐C) HIV</topic><topic>diversity</topic><topic>genotype</topic><topic>recombination</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>685</start><end>694</end><total>10</total></extent></part></relatedItem><identifier type="istex">EB2529154B667E683E8D54B84C26E72A2DCCACB4</identifier><identifier type="DOI">10.1002/jmv.22029</identifier><identifier type="ArticleID">JMV22029</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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