Novel, potentially zoonotic paramyxoviruses from the African straw-colored fruit bat Eidolon helvum.
Identifieur interne : 000579 ( Main/Curation ); précédent : 000578; suivant : 000580Novel, potentially zoonotic paramyxoviruses from the African straw-colored fruit bat Eidolon helvum.
Auteurs : Kate S. Baker [Royaume-Uni] ; Shawn Todd ; Glenn A. Marsh ; Gary Crameri ; Jennifer Barr ; Alexandra O. Kamins ; Alison J. Peel ; Meng Yu ; David T S. Hayman ; Behzad Nadjm ; George Mtove ; Benjamin Amos ; Hugh Reyburn ; Edward Nyarko ; Richard Suu-Ire ; Pablo R. Murcia ; Andrew A. Cunningham ; James L N. Wood ; Lin-Fa WangSource :
- Journal of virology [ 1098-5514 ] ; 2013.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Adolescent, Adulte, Afrique (épidémiologie), Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Anticorps antiviraux (sang), Chiroptera (virologie), Données de séquences moléculaires, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à rubulavirus (médecine vétérinaire), Infections à rubulavirus (virologie), Infections à rubulavirus (épidémiologie), Mâle, Nourrisson, Phylogénie, Rubulavirus (), Rubulavirus (génétique), Rubulavirus (isolement et purification), Rubulavirus (pathogénicité), Zoonoses (épidémiologie), Études séroépidémiologiques.
- MESH :
- génétique : ARN viral, Rubulavirus.
- isolement et purification : Rubulavirus.
- médecine vétérinaire : Infections à rubulavirus.
- pathogénicité : Rubulavirus.
- sang : Anticorps antiviraux.
- virologie : Chiroptera, Infections à rubulavirus.
- épidémiologie : Afrique, Infections à rubulavirus, Zoonoses.
- Adolescent, Adulte, Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson, Phylogénie, Rubulavirus, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adolescent, Adult, Africa (epidemiology), Animals, Antibodies, Viral (blood), Child, Child, Preschool, Chiroptera (virology), Cluster Analysis, Female, Humans, Infant, Male, Molecular Sequence Data, Phylogeny, RNA, Viral (genetics), Rubulavirus (classification), Rubulavirus (genetics), Rubulavirus (isolation & purification), Rubulavirus (pathogenicity), Rubulavirus Infections (epidemiology), Rubulavirus Infections (veterinary), Rubulavirus Infections (virology), Sequence Analysis, DNA, Seroepidemiologic Studies, Zoonoses (epidemiology).
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Africa.
- chemical , genetics : RNA, Viral.
- classification : Rubulavirus.
- epidemiology : Rubulavirus Infections, Zoonoses.
- genetics : Rubulavirus.
- isolation & purification : Rubulavirus.
- pathogenicity : Rubulavirus.
- veterinary : Rubulavirus Infections.
- virology : Chiroptera, Rubulavirus Infections.
- Adolescent, Adult, Animals, Child, Child, Preschool, Cluster Analysis, Female, Humans, Infant, Male, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, Seroepidemiologic Studies.
Abstract
Bats carry a variety of paramyxoviruses that impact human and domestic animal health when spillover occurs. Recent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw-colored fruit bats in Ghana. Here, we investigate this further through virus isolation and describe two novel rubulaviruses: Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2). The viruses form a phylogenetic cluster with each other and other bat-derived rubulaviruses, such as Tuhoko viruses, Menangle virus, and Tioman virus. We developed AchPV1- and AchPV2-specific serological assays and found evidence of infection with both viruses in Eidolon helvum across sub-Saharan Africa and on islands in the Gulf of Guinea. Longitudinal sampling of E. helvum indicates virus persistence within fruit bat populations and suggests spread of AchPVs via horizontal transmission. We also detected possible serological evidence of human infection with AchPV2 in Ghana and Tanzania. It is likely that clinically significant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Africa where health surveillance and diagnostics are poor and comorbidities, such as infection with HIV or Plasmodium sp., are common.
DOI: 10.1128/JVI.01202-12
PubMed: 23152534
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pubmed:23152534Le document en format XML
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<front><div type="abstract" xml:lang="en">Bats carry a variety of paramyxoviruses that impact human and domestic animal health when spillover occurs. Recent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw-colored fruit bats in Ghana. Here, we investigate this further through virus isolation and describe two novel rubulaviruses: Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2). The viruses form a phylogenetic cluster with each other and other bat-derived rubulaviruses, such as Tuhoko viruses, Menangle virus, and Tioman virus. We developed AchPV1- and AchPV2-specific serological assays and found evidence of infection with both viruses in Eidolon helvum across sub-Saharan Africa and on islands in the Gulf of Guinea. Longitudinal sampling of E. helvum indicates virus persistence within fruit bat populations and suggests spread of AchPVs via horizontal transmission. We also detected possible serological evidence of human infection with AchPV2 in Ghana and Tanzania. It is likely that clinically significant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Africa where health surveillance and diagnostics are poor and comorbidities, such as infection with HIV or Plasmodium sp., are common.</div>
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