SidaGhanaV1, Istex, Curation, bibRecord, 000084

Vertical transmission of HIV in Ghanaian women diagnosed in cord blood and post‐natal samples

Identifieur interne : 000084 ( Istex/Curation ); précédent : 000083; suivant : 000085

Vertical transmission of HIV in Ghanaian women diagnosed in cord blood and post‐natal samples

Auteurs : Lucia Fischetti [Royaume-Uni] ; Kwabena Danso [Ghana] ; Albert Dompreh [Ghana] ; Victor Addo [Ghana] ; Lars Haaheim [Norvège] ; Jean-Pierre Allain [Royaume-Uni]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2005-11.

RBID : ISTEX:A1B968CCD0DD7DCBA22EA04C3533EB8185C35061

English descriptors

Abstract

HIV RNA detection in the newborn is the main diagnostic tool for vertical transmission. Most infections are thought to occur peri‐ or post‐natally, hence preventive antiviral therapy administered days before and during delivery. This study used cord blood for molecular diagnosis, examined viral load and HIV‐1 subtypes as determinants of transmission, and compared molecular variability of maternal, cord blood, and post‐natal quasispecies. Ninety‐seven seropositive mother‐cord blood paired plasmas from Ghana were tested for HIV RNA. Viral load was quantified and a subgroup of 45 random women samples was typed and subtyped. HIV‐1 from infected pairs was cloned, sequenced, and analyzed phylogenetically. The prevalence of HIV infection in pregnant women was 3.3%. 13/97 cord blood samples (13.5%) contained HIV RNA. No correlation between either viral load at labor (range 103–107) or HIV‐1 subtype and in utero transmission was found. In both transmitting and non‐transmitting mothers, 56% of HIV‐1 strains were CRF02_AG. In three pairs, maternal and cord blood quasispecies were closely related, suggesting late pregnancy or perinatal transmission, while in four pairs, genetic distances suggested transmission earlier during gestation. Maternal viral load and genotype did not correlate with HIV‐1 pre‐natal transmission. HIV infection during gestation appears relatively frequent. J. Med. Virol. 77:351–359, 2005. © 2005 Wiley‐Liss, Inc.

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https://api.istex.fr/document/A1B968CCD0DD7DCBA22EA04C3533EB8185C35061/fulltext/pdf

DOI: 10.1002/jmv.20463

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Le document en format XML

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<affiliation wicri:level="1"><mods:affiliation>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, United Kingdom</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge</wicri:regionArea>
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<author><name sortKey="Danso, Kwabena" sort="Danso, Kwabena" uniqKey="Danso K" first="Kwabena" last="Danso">Kwabena Danso</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aids fischetti</term>
<term>Blood donors</term>
<term>Blood pairs</term>
<term>Clone</term>
<term>Cord</term>
<term>Cord blood</term>
<term>Cord blood clones</term>
<term>Cord blood quasispecies</term>
<term>Cord blood samples</term>
<term>Cord clones</term>
<term>Cord quasispecies</term>
<term>Detectable virus</term>
<term>Fischetti</term>
<term>Genetic distance</term>
<term>Genetic diversity</term>
<term>Genetic variability</term>
<term>Genital secretions</term>
<term>Genotype</term>
<term>Higher prevalence</term>
<term>Human virus</term>
<term>Human virus type</term>
<term>Immune response</term>
<term>Infection prevalence</term>
<term>Intrapartum transmission</term>
<term>Komfo anokye teaching hospital</term>
<term>Maternal</term>
<term>Maternal clones</term>
<term>Maternal plasma</term>
<term>Maternal quasispecies</term>
<term>Maternal variants</term>
<term>Median</term>
<term>Minor variant</term>
<term>Molecular epidemiology</term>
<term>Multiple variants</term>
<term>Newborn sample</term>
<term>Newborn samples</term>
<term>Novel diagnostics</term>
<term>Nucleotide distances</term>
<term>Other studies</term>
<term>Overall rate</term>
<term>Perinatal</term>
<term>Perinatal transmission</term>
<term>Peripheral blood</term>
<term>Pregnant women</term>
<term>Quasispecies</term>
<term>Second round</term>
<term>Selective processes</term>
<term>Several studies</term>
<term>Small number</term>
<term>Study group</term>
<term>Subtype</term>
<term>Subtype distribution</term>
<term>Subtypes</term>
<term>Transfusion medicine</term>
<term>Transmission</term>
<term>Utero</term>
<term>Utero transmission</term>
<term>Variant</term>
<term>Vertical transmission</term>
<term>Viral</term>
<term>Viral compartmentalization</term>
<term>Viral load</term>
<term>Viral load distribution</term>
<term>Viral quasispecies</term>
<term>Virol</term>
<term>Virus populations</term>
<term>Virus type</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Aids fischetti</term>
<term>Blood donors</term>
<term>Blood pairs</term>
<term>Clone</term>
<term>Cord</term>
<term>Cord blood</term>
<term>Cord blood clones</term>
<term>Cord blood quasispecies</term>
<term>Cord blood samples</term>
<term>Cord clones</term>
<term>Cord quasispecies</term>
<term>Detectable virus</term>
<term>Fischetti</term>
<term>Genetic distance</term>
<term>Genetic diversity</term>
<term>Genetic variability</term>
<term>Genital secretions</term>
<term>Genotype</term>
<term>Higher prevalence</term>
<term>Human virus</term>
<term>Human virus type</term>
<term>Immune response</term>
<term>Infection prevalence</term>
<term>Intrapartum transmission</term>
<term>Komfo anokye teaching hospital</term>
<term>Maternal</term>
<term>Maternal clones</term>
<term>Maternal plasma</term>
<term>Maternal quasispecies</term>
<term>Maternal variants</term>
<term>Median</term>
<term>Minor variant</term>
<term>Molecular epidemiology</term>
<term>Multiple variants</term>
<term>Newborn sample</term>
<term>Newborn samples</term>
<term>Novel diagnostics</term>
<term>Nucleotide distances</term>
<term>Other studies</term>
<term>Overall rate</term>
<term>Perinatal</term>
<term>Perinatal transmission</term>
<term>Peripheral blood</term>
<term>Pregnant women</term>
<term>Quasispecies</term>
<term>Second round</term>
<term>Selective processes</term>
<term>Several studies</term>
<term>Small number</term>
<term>Study group</term>
<term>Subtype</term>
<term>Subtype distribution</term>
<term>Subtypes</term>
<term>Transfusion medicine</term>
<term>Transmission</term>
<term>Utero</term>
<term>Utero transmission</term>
<term>Variant</term>
<term>Vertical transmission</term>
<term>Viral</term>
<term>Viral compartmentalization</term>
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<front><div type="abstract" xml:lang="en">HIV RNA detection in the newborn is the main diagnostic tool for vertical transmission. Most infections are thought to occur peri‐ or post‐natally, hence preventive antiviral therapy administered days before and during delivery. This study used cord blood for molecular diagnosis, examined viral load and HIV‐1 subtypes as determinants of transmission, and compared molecular variability of maternal, cord blood, and post‐natal quasispecies. Ninety‐seven seropositive mother‐cord blood paired plasmas from Ghana were tested for HIV RNA. Viral load was quantified and a subgroup of 45 random women samples was typed and subtyped. HIV‐1 from infected pairs was cloned, sequenced, and analyzed phylogenetically. The prevalence of HIV infection in pregnant women was 3.3%. 13/97 cord blood samples (13.5%) contained HIV RNA. No correlation between either viral load at labor (range 103–107) or HIV‐1 subtype and in utero transmission was found. In both transmitting and non‐transmitting mothers, 56% of HIV‐1 strains were CRF02_AG. In three pairs, maternal and cord blood quasispecies were closely related, suggesting late pregnancy or perinatal transmission, while in four pairs, genetic distances suggested transmission earlier during gestation. Maternal viral load and genotype did not correlate with HIV‐1 pre‐natal transmission. HIV infection during gestation appears relatively frequent. J. Med. Virol. 77:351–359, 2005. © 2005 Wiley‐Liss, Inc.</div>
</front>
</TEI>
</record>

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	Le SIDA au Ghana (serveur d'exploration)
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Le SIDA au Ghana (serveur d'exploration)

Vertical transmission of HIV in Ghanaian women diagnosed in cord blood and post‐natal samples

Vertical transmission of HIV in Ghanaian women diagnosed in cord blood and post‐natal samples

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri