The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya
Identifieur interne : 000756 ( Istex/Corpus ); précédent : 000755; suivant : 000757The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya
Auteurs : Oliver W. Hassall ; Johnstone Thitiri ; Greg Fegan ; Lewa Pole ; Salim Mwarumba ; Douglas Denje ; Kongo Wambua ; Brett Lowe ; Christopher M. Parry ; Kishor Mandaliya ; Kathryn Maitland ; Imelda BatesSource :
- Transfusion [ 0041-1132 ] ; 2012-07.
English descriptors
- KwdEn :
- Antenatal, Bacillus, Bacterial contamination, Blood donors, Blood packs, Blood safety, Blood transfusion, Clinical trials, Contaminant, Contamination, Conventional blood, Conventional blood donors, Conventional blood pack, Conventional blood packs, Conventional donors, Cord, Cord blood, Cord blood collection, Cord blood donation, Cord blood donations, Cord blood donors, Cord blood pack, Cord blood packs, Cord blood transfusion, Cpgh, Donation, Donor, General hospital, Hassall, July, Kenya, Kenyan hospital, Labor ward, Maternal serum, Mombasa, Positive poststorage culture, Poststorage, Poststorage culture, Poststorage cultures, Primary objective, Rbtc, Residual risk, Screening, Screening culture, Screening cultures, Serology results, Seroreactivity, Severe anaemia, Severe anemia, Staphylococcus epidermidis, Streptococcus, Streptococcus group, Subsaharan africa, Syphilis, Transfusion, Transfusion volume, Umbilical, West africa, Whole blood, Young children.
- Teeft :
- Antenatal, Bacillus, Bacterial contamination, Blood donors, Blood packs, Blood safety, Blood transfusion, Clinical trials, Contaminant, Contamination, Conventional blood, Conventional blood donors, Conventional blood pack, Conventional blood packs, Conventional donors, Cord, Cord blood, Cord blood collection, Cord blood donation, Cord blood donations, Cord blood donors, Cord blood pack, Cord blood packs, Cord blood transfusion, Cpgh, Donation, Donor, General hospital, Hassall, July, Kenya, Kenyan hospital, Labor ward, Maternal serum, Mombasa, Positive poststorage culture, Poststorage, Poststorage culture, Poststorage cultures, Primary objective, Rbtc, Residual risk, Screening, Screening culture, Screening cultures, Serology results, Seroreactivity, Severe anaemia, Severe anemia, Staphylococcus epidermidis, Streptococcus, Streptococcus group, Subsaharan africa, Syphilis, Transfusion, Transfusion volume, Umbilical, West africa, Whole blood, Young children.
Abstract
BACKGROUND: Severe anemia requiring blood transfusion is common in hospitalized young children in sub‐Saharan Africa but blood is often in short supply. Umbilical cord blood may be a useful source of blood if microbiologic safety concerns can be addressed.
Url:
DOI: 10.1111/j.1537-2995.2011.03487.x
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ISTEX:5301402E9EEF5A37AF7977C1BB6A48E933A9D6AFLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title><author><name sortKey="Hassall, Oliver W" sort="Hassall, Oliver W" uniqKey="Hassall O" first="Oliver W." last="Hassall">Oliver W. Hassall</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ohassall@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Thitiri, Johnstone" sort="Thitiri, Johnstone" uniqKey="Thitiri J" first="Johnstone" last="Thitiri">Johnstone Thitiri</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Fegan, Greg" sort="Fegan, Greg" uniqKey="Fegan G" first="Greg" last="Fegan">Greg Fegan</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Pole, Lewa" sort="Pole, Lewa" uniqKey="Pole L" first="Lewa" last="Pole">Lewa Pole</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Mwarumba, Salim" sort="Mwarumba, Salim" uniqKey="Mwarumba S" first="Salim" last="Mwarumba">Salim Mwarumba</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Denje, Douglas" sort="Denje, Douglas" uniqKey="Denje D" first="Douglas" last="Denje">Douglas Denje</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Wambua, Kongo" sort="Wambua, Kongo" uniqKey="Wambua K" first="Kongo" last="Wambua">Kongo Wambua</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Lowe, Brett" sort="Lowe, Brett" uniqKey="Lowe B" first="Brett" last="Lowe">Brett Lowe</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Parry, Christopher M" sort="Parry, Christopher M" uniqKey="Parry C" first="Christopher M." last="Parry">Christopher M. Parry</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Mandaliya, Kishor" sort="Mandaliya, Kishor" uniqKey="Mandaliya K" first="Kishor" last="Mandaliya">Kishor Mandaliya</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Maitland, Kathryn" sort="Maitland, Kathryn" uniqKey="Maitland K" first="Kathryn" last="Maitland">Kathryn Maitland</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Bates, Imelda" sort="Bates, Imelda" uniqKey="Bates I" first="Imelda" last="Bates">Imelda Bates</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1111/j.1537-2995.2011.03487.x</idno><idno type="url">https://api.istex.fr/document/5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000756</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000756</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title><author><name sortKey="Hassall, Oliver W" sort="Hassall, Oliver W" uniqKey="Hassall O" first="Oliver W." last="Hassall">Oliver W. Hassall</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ohassall@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Thitiri, Johnstone" sort="Thitiri, Johnstone" uniqKey="Thitiri J" first="Johnstone" last="Thitiri">Johnstone Thitiri</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Fegan, Greg" sort="Fegan, Greg" uniqKey="Fegan G" first="Greg" last="Fegan">Greg Fegan</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Pole, Lewa" sort="Pole, Lewa" uniqKey="Pole L" first="Lewa" last="Pole">Lewa Pole</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Mwarumba, Salim" sort="Mwarumba, Salim" uniqKey="Mwarumba S" first="Salim" last="Mwarumba">Salim Mwarumba</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Denje, Douglas" sort="Denje, Douglas" uniqKey="Denje D" first="Douglas" last="Denje">Douglas Denje</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Wambua, Kongo" sort="Wambua, Kongo" uniqKey="Wambua K" first="Kongo" last="Wambua">Kongo Wambua</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Lowe, Brett" sort="Lowe, Brett" uniqKey="Lowe B" first="Brett" last="Lowe">Brett Lowe</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Parry, Christopher M" sort="Parry, Christopher M" uniqKey="Parry C" first="Christopher M." last="Parry">Christopher M. Parry</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Mandaliya, Kishor" sort="Mandaliya, Kishor" uniqKey="Mandaliya K" first="Kishor" last="Mandaliya">Kishor Mandaliya</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Maitland, Kathryn" sort="Maitland, Kathryn" uniqKey="Maitland K" first="Kathryn" last="Maitland">Kathryn Maitland</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author><author><name sortKey="Bates, Imelda" sort="Bates, Imelda" uniqKey="Bates I" first="Imelda" last="Bates">Imelda Bates</name><affiliation><mods:affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="ISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><imprint><biblScope unit="vol">52</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1542">1542</biblScope><biblScope unit="page" to="1551">1551</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2012-07">2012-07</date></imprint><idno type="ISSN">0041-1132</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antenatal</term><term>Bacillus</term><term>Bacterial contamination</term><term>Blood donors</term><term>Blood packs</term><term>Blood safety</term><term>Blood transfusion</term><term>Clinical trials</term><term>Contaminant</term><term>Contamination</term><term>Conventional blood</term><term>Conventional blood donors</term><term>Conventional blood pack</term><term>Conventional blood packs</term><term>Conventional donors</term><term>Cord</term><term>Cord blood</term><term>Cord blood collection</term><term>Cord blood donation</term><term>Cord blood donations</term><term>Cord blood donors</term><term>Cord blood pack</term><term>Cord blood packs</term><term>Cord blood transfusion</term><term>Cpgh</term><term>Donation</term><term>Donor</term><term>General hospital</term><term>Hassall</term><term>July</term><term>Kenya</term><term>Kenyan hospital</term><term>Labor ward</term><term>Maternal serum</term><term>Mombasa</term><term>Positive poststorage culture</term><term>Poststorage</term><term>Poststorage culture</term><term>Poststorage cultures</term><term>Primary objective</term><term>Rbtc</term><term>Residual risk</term><term>Screening</term><term>Screening culture</term><term>Screening cultures</term><term>Serology results</term><term>Seroreactivity</term><term>Severe anaemia</term><term>Severe anemia</term><term>Staphylococcus epidermidis</term><term>Streptococcus</term><term>Streptococcus group</term><term>Subsaharan africa</term><term>Syphilis</term><term>Transfusion</term><term>Transfusion volume</term><term>Umbilical</term><term>West africa</term><term>Whole blood</term><term>Young children</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antenatal</term><term>Bacillus</term><term>Bacterial contamination</term><term>Blood donors</term><term>Blood packs</term><term>Blood safety</term><term>Blood transfusion</term><term>Clinical trials</term><term>Contaminant</term><term>Contamination</term><term>Conventional blood</term><term>Conventional blood donors</term><term>Conventional blood pack</term><term>Conventional blood packs</term><term>Conventional donors</term><term>Cord</term><term>Cord blood</term><term>Cord blood collection</term><term>Cord blood donation</term><term>Cord blood donations</term><term>Cord blood donors</term><term>Cord blood pack</term><term>Cord blood packs</term><term>Cord blood transfusion</term><term>Cpgh</term><term>Donation</term><term>Donor</term><term>General hospital</term><term>Hassall</term><term>July</term><term>Kenya</term><term>Kenyan hospital</term><term>Labor ward</term><term>Maternal serum</term><term>Mombasa</term><term>Positive poststorage culture</term><term>Poststorage</term><term>Poststorage culture</term><term>Poststorage cultures</term><term>Primary objective</term><term>Rbtc</term><term>Residual risk</term><term>Screening</term><term>Screening culture</term><term>Screening cultures</term><term>Serology results</term><term>Seroreactivity</term><term>Severe anaemia</term><term>Severe anemia</term><term>Staphylococcus epidermidis</term><term>Streptococcus</term><term>Streptococcus group</term><term>Subsaharan africa</term><term>Syphilis</term><term>Transfusion</term><term>Transfusion volume</term><term>Umbilical</term><term>West africa</term><term>Whole blood</term><term>Young children</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">BACKGROUND: Severe anemia requiring blood transfusion is common in hospitalized young children in sub‐Saharan Africa but blood is often in short supply. Umbilical cord blood may be a useful source of blood if microbiologic safety concerns can be addressed.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>transfusion</json:string><json:string>cord blood</json:string><json:string>poststorage</json:string><json:string>kenya</json:string><json:string>cord blood donors</json:string><json:string>conventional blood</json:string><json:string>syphilis</json:string><json:string>bacterial contamination</json:string><json:string>poststorage culture</json:string><json:string>mombasa</json:string><json:string>cord blood packs</json:string><json:string>seroreactivity</json:string><json:string>conventional blood donors</json:string><json:string>rbtc</json:string><json:string>cord</json:string><json:string>cpgh</json:string><json:string>hassall</json:string><json:string>antenatal</json:string><json:string>umbilical</json:string><json:string>july</json:string><json:string>screening culture</json:string><json:string>conventional blood packs</json:string><json:string>streptococcus group</json:string><json:string>donor</json:string><json:string>blood packs</json:string><json:string>cord blood collection</json:string><json:string>contaminant</json:string><json:string>blood transfusion</json:string><json:string>severe anemia</json:string><json:string>cord blood donations</json:string><json:string>subsaharan africa</json:string><json:string>poststorage cultures</json:string><json:string>cord blood transfusion</json:string><json:string>labor ward</json:string><json:string>donation</json:string><json:string>cord blood donation</json:string><json:string>transfusion volume</json:string><json:string>whole blood</json:string><json:string>young children</json:string><json:string>streptococcus</json:string><json:string>contamination</json:string><json:string>screening</json:string><json:string>clinical trials</json:string><json:string>conventional donors</json:string><json:string>screening cultures</json:string><json:string>staphylococcus epidermidis</json:string><json:string>blood donors</json:string><json:string>severe anaemia</json:string><json:string>bacillus</json:string><json:string>maternal serum</json:string><json:string>general hospital</json:string><json:string>primary objective</json:string><json:string>positive poststorage culture</json:string><json:string>cord blood pack</json:string><json:string>serology results</json:string><json:string>conventional blood pack</json:string><json:string>residual risk</json:string><json:string>kenyan hospital</json:string><json:string>blood safety</json:string><json:string>west africa</json:string></teeft></keywords><author><json:item><name>Oliver W. Hassall</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string><json:string>E-mail: ohassall@gmail.com</json:string></affiliations></json:item><json:item><name>Johnstone Thitiri</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Greg Fegan</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Lewa Pole</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Salim Mwarumba</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Douglas Denje</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Kongo Wambua</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Brett Lowe</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Christopher M. Parry</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Kishor Mandaliya</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Kathryn Maitland</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item><json:item><name>Imelda Bates</name><affiliations><json:string>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</json:string></affiliations></json:item></author><articleId><json:string>TRF3487</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>5.468</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>256</abstractCharCount><pdfWordCount>6516</pdfWordCount><pdfCharCount>41015</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>39</abstractWordCount></qualityIndicators><title>The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title><genre><json:string>article</json:string></genre><host><title>Transfusion</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1537-2995</json:string></doi><issn><json:string>0041-1132</json:string></issn><eissn><json:string>1537-2995</json:string></eissn><publisherId><json:string>TRF</json:string></publisherId><volume>52</volume><issue>7</issue><pages><first>1542</first><last>1551</last><total>10</total></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>hematology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>cardiovascular system & hematology</json:string></scienceMetrix></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1111/j.1537-2995.2011.03487.x</json:string></doi><id>5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><licence>© 2011 American Association of Blood Banks</licence></availability><date type="published" when="2012-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title><title level="a" type="short">SAFETY OF CORD BLOOD IN MOMBASA, KENYA</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Oliver W.</forename><surname>Hassall</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation><affiliation>Oliver Hassall, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF, UK; e‐mail: ohassall@gmail.com.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Johnstone</forename><surname>Thitiri</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Greg</forename><surname>Fegan</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Lewa</forename><surname>Pole</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Salim</forename><surname>Mwarumba</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Douglas</forename><surname>Denje</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Kongo</forename><surname>Wambua</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Brett</forename><surname>Lowe</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Christopher M.</forename><surname>Parry</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Kishor</forename><surname>Mandaliya</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Kathryn</forename><surname>Maitland</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Imelda</forename><surname>Bates</surname></persName><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.<address><country key="GB"></country></address></affiliation></author><idno type="istex">5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF</idno><idno type="DOI">10.1111/j.1537-2995.2011.03487.x</idno><idno type="unit">TRF3487</idno><idno type="toTypesetVersion">file:TRF.TRF3487.pdf</idno></analytic><monogr><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="pISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><idno type="book-DOI">10.1111/(ISSN)1537-2995</idno><idno type="book-part-DOI">10.1111/trf.2012.52.issue-7</idno><idno type="product">TRF</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">52</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1542">1542</biblScope><biblScope unit="page" to="1551">1551</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2012-07"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">BACKGROUND:</hi> Severe anemia requiring blood transfusion is common in hospitalized young children in sub‐Saharan Africa but blood is often in short supply. Umbilical cord blood may be a useful source of blood if microbiologic safety concerns can be addressed.</p><p><hi rend="bold">STUDY DESIGN AND METHODS:</hi> Cord blood, donated on the labor ward at the provincial hospital in Mombasa, was cultured soon after collection (screening culture) and after a period of storage (poststorage culture). Conventional blood transfused to children at the hospital was cultured only at the time of issue (poststorage culture). Maternal sera (cord blood) and conventional blood donations were also screened for transfusion‐transmitted infection.</p><p><hi rend="bold">RESULTS:</hi> At poststorage culture, the overall contamination rate of cord blood was one‐third that of conventional blood (13/449 vs. 38/434; odds ratio [OR], 0.31; 95% confidence interval [CI], 0.15‐0.61) and for bacteria of high pathogenic potential it was half that of conventional blood (4/449 vs. 7/434; OR, 0.55; 95% CI, 0.12‐2.18). Screening cultures were positive in 50% (2/4) of cord blood packs where an organism of high pathogenic potential was isolated at poststorage culture. Cord blood donors had a lower seroreactivity than conventional donors for human immunodeficiency virus (OR, 0.63; 95% CI, 0.29‐1.18), hepatitis B virus (OR, 0.32; 95% CI, 0.16‐0.59), and hepatitis C virus (OR, 0.20; 95% CI, 0.24‐0.76). For syphilis, initial seroreactivity in cord blood donors was 3.8% compared to 1.8% in conventional blood donors (OR, 2.10; 95% CI, 1.15‐3.60) but was 0.5% after retesting.</p><p><hi rend="bold">CONCLUSION:</hi> With respect to bacterial contamination and seroreactivity for transfusion‐transmitted infection, the safety of cord blood in Mombasa compares favorably with conventional blood. Clinical trials of cord blood transfusion are justified.</p></abstract><textClass><classCode scheme="tocHeading1">TRANSFUSION PRACTICE</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1537-2995</doi><issn type="print">0041-1132</issn><issn type="electronic">1537-2995</issn><idGroup><id type="product" value="TRF"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="TRANSFUSION">Transfusion</title></titleGroup></publicationMeta><publicationMeta level="part" position="07107"><doi origin="wiley">10.1111/trf.2012.52.issue-7</doi><numberingGroup><numbering type="journalVolume" number="52">52</numbering><numbering type="journalIssue" number="7">7</numbering></numberingGroup><coverDate startDate="2012-07">July 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="23" status="forIssue"><doi origin="wiley">10.1111/j.1537-2995.2011.03487.x</doi><idGroup><id type="unit" value="TRF3487"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="tocHeading1">TRANSFUSION PRACTICE</title></titleGroup><copyright>© 2011 American Association of Blood Banks</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.5.1 mode:FullText" date="2012-07-10"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-12-21"></event><event type="firstOnline" date="2011-12-21"></event><event type="publishedOnlineFinalForm" date="2012-07-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1542">1542</numbering><numbering type="pageLast" number="1551">1551</numbering></numberingGroup><correspondenceTo>Oliver Hassall, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF, UK; e‐mail: <email>ohassall@gmail.com</email>.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TRF.TRF3487.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received for publication April 14, 2011; revision received September 29, 2011, and accepted November 8, 2011.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="5"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="43"></count><count type="wordTotal" number="7614"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title><title type="shortAuthors">HASSALL ET AL.</title><title type="short">SAFETY OF CORD BLOOD IN MOMBASA, KENYA</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Oliver W.</givenNames><familyName>Hassall</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Johnstone</givenNames><familyName>Thitiri</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Greg</givenNames><familyName>Fegan</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Lewa</givenNames><familyName>Pole</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Salim</givenNames><familyName>Mwarumba</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Douglas</givenNames><familyName>Denje</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>Kongo</givenNames><familyName>Wambua</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1"><personName><givenNames>Brett</givenNames><familyName>Lowe</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>Christopher M.</givenNames><familyName>Parry</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a1"><personName><givenNames>Kishor</givenNames><familyName>Mandaliya</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a1"><personName><givenNames>Kathryn</givenNames><familyName>Maitland</familyName></personName></creator><creator creatorRole="author" xml:id="cr12" affiliationRef="#a1"><personName><givenNames>Imelda</givenNames><familyName>Bates</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>BACKGROUND:</b> Severe anemia requiring blood transfusion is common in hospitalized young children in sub‐Saharan Africa but blood is often in short supply. Umbilical cord blood may be a useful source of blood if microbiologic safety concerns can be addressed.</p><p><b>STUDY DESIGN AND METHODS:</b> Cord blood, donated on the labor ward at the provincial hospital in Mombasa, was cultured soon after collection (screening culture) and after a period of storage (poststorage culture). Conventional blood transfused to children at the hospital was cultured only at the time of issue (poststorage culture). Maternal sera (cord blood) and conventional blood donations were also screened for transfusion‐transmitted infection.</p><p><b>RESULTS:</b> At poststorage culture, the overall contamination rate of cord blood was one‐third that of conventional blood (13/449 vs. 38/434; odds ratio [OR], 0.31; 95% confidence interval [CI], 0.15‐0.61) and for bacteria of high pathogenic potential it was half that of conventional blood (4/449 vs. 7/434; OR, 0.55; 95% CI, 0.12‐2.18). Screening cultures were positive in 50% (2/4) of cord blood packs where an organism of high pathogenic potential was isolated at poststorage culture. Cord blood donors had a lower seroreactivity than conventional donors for human immunodeficiency virus (OR, 0.63; 95% CI, 0.29‐1.18), hepatitis B virus (OR, 0.32; 95% CI, 0.16‐0.59), and hepatitis C virus (OR, 0.20; 95% CI, 0.24‐0.76). For syphilis, initial seroreactivity in cord blood donors was 3.8% compared to 1.8% in conventional blood donors (OR, 2.10; 95% CI, 1.15‐3.60) but was 0.5% after retesting.</p><p><b>CONCLUSION:</b> With respect to bacterial contamination and seroreactivity for transfusion‐transmitted infection, the safety of cord blood in Mombasa compares favorably with conventional blood. Clinical trials of cord blood transfusion are justified.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>OWH was supported by a Wellcome Trust Training Fellowship (073604).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SAFETY OF CORD BLOOD IN MOMBASA, KENYA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya</title></titleInfo><name type="personal"><namePart type="given">Oliver W.</namePart><namePart type="family">Hassall</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><affiliation>E-mail: ohassall@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johnstone</namePart><namePart type="family">Thitiri</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Greg</namePart><namePart type="family">Fegan</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lewa</namePart><namePart type="family">Pole</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Salim</namePart><namePart type="family">Mwarumba</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Douglas</namePart><namePart type="family">Denje</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kongo</namePart><namePart type="family">Wambua</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brett</namePart><namePart type="family">Lowe</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christopher M.</namePart><namePart type="family">Parry</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kishor</namePart><namePart type="family">Mandaliya</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathryn</namePart><namePart type="family">Maitland</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Imelda</namePart><namePart type="family">Bates</namePart><affiliation>From the Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya; the Department of Primary Health Care and the Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK; the Coast Provincial General Hospital and the Regional Blood Transfusion Centre, Mombasa, Kenya; Angkor Hospital for Children, Mahidol‐Oxford Tropical Medicine Research Unit, Siem Reap, Cambodia; the Department of Paediatrics, Imperial College London, London, UK; and the Liverpool School of Tropical Medicine, Liverpool, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2012-07</dateIssued><edition>Received for publication April 14, 2011; revision received September 29, 2011, and accepted November 8, 2011.</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent><extent unit="references">43</extent><extent unit="words">7614</extent></physicalDescription><abstract>BACKGROUND: Severe anemia requiring blood transfusion is common in hospitalized young children in sub‐Saharan Africa but blood is often in short supply. Umbilical cord blood may be a useful source of blood if microbiologic safety concerns can be addressed.</abstract><abstract>STUDY DESIGN AND METHODS: Cord blood, donated on the labor ward at the provincial hospital in Mombasa, was cultured soon after collection (screening culture) and after a period of storage (poststorage culture). Conventional blood transfused to children at the hospital was cultured only at the time of issue (poststorage culture). Maternal sera (cord blood) and conventional blood donations were also screened for transfusion‐transmitted infection.</abstract><abstract>RESULTS: At poststorage culture, the overall contamination rate of cord blood was one‐third that of conventional blood (13/449 vs. 38/434; odds ratio [OR], 0.31; 95% confidence interval [CI], 0.15‐0.61) and for bacteria of high pathogenic potential it was half that of conventional blood (4/449 vs. 7/434; OR, 0.55; 95% CI, 0.12‐2.18). Screening cultures were positive in 50% (2/4) of cord blood packs where an organism of high pathogenic potential was isolated at poststorage culture. Cord blood donors had a lower seroreactivity than conventional donors for human immunodeficiency virus (OR, 0.63; 95% CI, 0.29‐1.18), hepatitis B virus (OR, 0.32; 95% CI, 0.16‐0.59), and hepatitis C virus (OR, 0.20; 95% CI, 0.24‐0.76). For syphilis, initial seroreactivity in cord blood donors was 3.8% compared to 1.8% in conventional blood donors (OR, 2.10; 95% CI, 1.15‐3.60) but was 0.5% after retesting.</abstract><abstract>CONCLUSION: With respect to bacterial contamination and seroreactivity for transfusion‐transmitted infection, the safety of cord blood in Mombasa compares favorably with conventional blood. Clinical trials of cord blood transfusion are justified.</abstract><relatedItem type="host"><titleInfo><title>Transfusion</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0041-1132</identifier><identifier type="eISSN">1537-2995</identifier><identifier type="DOI">10.1111/(ISSN)1537-2995</identifier><identifier type="PublisherID">TRF</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1542</start><end>1551</end><total>10</total></extent></part></relatedItem><identifier type="istex">5301402E9EEF5A37AF7977C1BB6A48E933A9D6AF</identifier><identifier type="DOI">10.1111/j.1537-2995.2011.03487.x</identifier><identifier type="ArticleID">TRF3487</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 American Association of Blood Banks</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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