The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.
Identifieur interne : 000629 ( Main/Corpus ); précédent : 000628; suivant : 000630The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.
Auteurs : Emanuele Spina ; Antonio Carotenuto ; Maria Gabriella Aceto ; Ilaria Cerillo ; Francesco Silvestre ; Francesco Arace ; Paolo Paone ; Giuseppe Orefice ; Rosa IodiceSource :
- Restorative neurology and neuroscience [ 1878-3627 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Cohort Studies (MeSH), Double-Blind Method (MeSH), Face (innervation), Female (MeSH), Functional Laterality (physiology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Movement Disorders (etiology), Movement Disorders (rehabilitation), Multiple Sclerosis (complications), Treatment Outcome (MeSH), Vibration (therapeutic use), Walking (physiology), Young Adult (MeSH).
- MESH :
- complications : Multiple Sclerosis.
- etiology : Movement Disorders.
- innervation : Face.
- physiology : Functional Laterality, Walking.
- rehabilitation : Movement Disorders.
- therapeutic use : Vibration.
- Adolescent, Adult, Aged, Cohort Studies, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome, Young Adult.
Abstract
BACKGROUND
Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin.
OBJECTIVE
To assess whether FV is effective on walking impairment in a cohort of MS patients.
METHODS
We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of FV vs sham vibration in 20 RR MS patients. Ten patients received treatment with the active device and ten patients sham treatment. Demographical, clinical and gait instrumental data analysis have been collected for each patient at baseline (T0), after treatment (T1) and after three weeks of wash out (T2).
RESULTS
Both groups were clinically and demographically comparable. Treated patients showed significant improvements during the first right step (FRS) (p = 0.007), average stride lenght (ASL) (p = 0.012), double support right (DSRT) (p = 0.016) and left (DSLT) (p = 0.003) time. Non-treated patients didn't show any significance for any dynamic variables. Moreover, on posturographic measurements we registered only a trend towards significance in swing area with eyes open (SAEO) (p = 0.087). We also found in treated group significant improvements in FRT (p = 0.018); BBS (p = 0.037) and FSS scales (p = 0.038) between T1 and T0. Lastly, we found a significant inverse correlation in the treated group between disease duration and percentage of improvement for DSLT (r = - 0.775; p = 0.014) in T1 vs T0 and percentage of improvement of FSS, with an inverse correlation with both disease duration (r = - 0.775; p = 0.014) and AGE (r = - 0.733, p = 0.025) in T1 vs T0CONCLUSION: Our results suggest a beneficial effect of FV on walking impairment in MS patients suffering from spasticity and/or postural instability, which partially lasted until follow up.
DOI: 10.3233/RNN-160665
PubMed: 27567760
Links to Exploration step
pubmed:27567760Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.</title><author><name sortKey="Spina, Emanuele" sort="Spina, Emanuele" uniqKey="Spina E" first="Emanuele" last="Spina">Emanuele Spina</name></author><author><name sortKey="Carotenuto, Antonio" sort="Carotenuto, Antonio" uniqKey="Carotenuto A" first="Antonio" last="Carotenuto">Antonio Carotenuto</name></author><author><name sortKey="Aceto, Maria Gabriella" sort="Aceto, Maria Gabriella" uniqKey="Aceto M" first="Maria Gabriella" last="Aceto">Maria Gabriella Aceto</name></author><author><name sortKey="Cerillo, Ilaria" sort="Cerillo, Ilaria" uniqKey="Cerillo I" first="Ilaria" last="Cerillo">Ilaria Cerillo</name></author><author><name sortKey="Silvestre, Francesco" sort="Silvestre, Francesco" uniqKey="Silvestre F" first="Francesco" last="Silvestre">Francesco Silvestre</name></author><author><name sortKey="Arace, Francesco" sort="Arace, Francesco" uniqKey="Arace F" first="Francesco" last="Arace">Francesco Arace</name></author><author><name sortKey="Paone, Paolo" sort="Paone, Paolo" uniqKey="Paone P" first="Paolo" last="Paone">Paolo Paone</name></author><author><name sortKey="Orefice, Giuseppe" sort="Orefice, Giuseppe" uniqKey="Orefice G" first="Giuseppe" last="Orefice">Giuseppe Orefice</name></author><author><name sortKey="Iodice, Rosa" sort="Iodice, Rosa" uniqKey="Iodice R" first="Rosa" last="Iodice">Rosa Iodice</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27567760</idno><idno type="pmid">27567760</idno><idno type="doi">10.3233/RNN-160665</idno><idno type="wicri:Area/Main/Corpus">000629</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000629</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.</title><author><name sortKey="Spina, Emanuele" sort="Spina, Emanuele" uniqKey="Spina E" first="Emanuele" last="Spina">Emanuele Spina</name></author><author><name sortKey="Carotenuto, Antonio" sort="Carotenuto, Antonio" uniqKey="Carotenuto A" first="Antonio" last="Carotenuto">Antonio Carotenuto</name></author><author><name sortKey="Aceto, Maria Gabriella" sort="Aceto, Maria Gabriella" uniqKey="Aceto M" first="Maria Gabriella" last="Aceto">Maria Gabriella Aceto</name></author><author><name sortKey="Cerillo, Ilaria" sort="Cerillo, Ilaria" uniqKey="Cerillo I" first="Ilaria" last="Cerillo">Ilaria Cerillo</name></author><author><name sortKey="Silvestre, Francesco" sort="Silvestre, Francesco" uniqKey="Silvestre F" first="Francesco" last="Silvestre">Francesco Silvestre</name></author><author><name sortKey="Arace, Francesco" sort="Arace, Francesco" uniqKey="Arace F" first="Francesco" last="Arace">Francesco Arace</name></author><author><name sortKey="Paone, Paolo" sort="Paone, Paolo" uniqKey="Paone P" first="Paolo" last="Paone">Paolo Paone</name></author><author><name sortKey="Orefice, Giuseppe" sort="Orefice, Giuseppe" uniqKey="Orefice G" first="Giuseppe" last="Orefice">Giuseppe Orefice</name></author><author><name sortKey="Iodice, Rosa" sort="Iodice, Rosa" uniqKey="Iodice R" first="Rosa" last="Iodice">Rosa Iodice</name></author></analytic><series><title level="j">Restorative neurology and neuroscience</title><idno type="eISSN">1878-3627</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Double-Blind Method (MeSH)</term><term>Face (innervation)</term><term>Female (MeSH)</term><term>Functional Laterality (physiology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (rehabilitation)</term><term>Multiple Sclerosis (complications)</term><term>Treatment Outcome (MeSH)</term><term>Vibration (therapeutic use)</term><term>Walking (physiology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Face</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Walking</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Vibration</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To assess whether FV is effective on walking impairment in a cohort of MS patients.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of FV vs sham vibration in 20 RR MS patients. Ten patients received treatment with the active device and ten patients sham treatment. Demographical, clinical and gait instrumental data analysis have been collected for each patient at baseline (T0), after treatment (T1) and after three weeks of wash out (T2).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Both groups were clinically and demographically comparable. Treated patients showed significant improvements during the first right step (FRS) (p = 0.007), average stride lenght (ASL) (p = 0.012), double support right (DSRT) (p = 0.016) and left (DSLT) (p = 0.003) time. Non-treated patients didn't show any significance for any dynamic variables. Moreover, on posturographic measurements we registered only a trend towards significance in swing area with eyes open (SAEO) (p = 0.087). We also found in treated group significant improvements in FRT (p = 0.018); BBS (p = 0.037) and FSS scales (p = 0.038) between T1 and T0. Lastly, we found a significant inverse correlation in the treated group between disease duration and percentage of improvement for DSLT (r = - 0.775; p = 0.014) in T1 vs T0 and percentage of improvement of FSS, with an inverse correlation with both disease duration (r = - 0.775; p = 0.014) and AGE (r = - 0.733, p = 0.025) in T1 vs T0CONCLUSION: Our results suggest a beneficial effect of FV on walking impairment in MS patients suffering from spasticity and/or postural instability, which partially lasted until follow up.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27567760</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>02</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1878-3627</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>09</Month><Day>21</Day></PubDate></JournalIssue><Title>Restorative neurology and neuroscience</Title><ISOAbbreviation>Restor Neurol Neurosci</ISOAbbreviation></Journal><ArticleTitle>The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.</ArticleTitle><Pagination><MedlinePgn>869-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/RNN-160665</ELocationID><Abstract><AbstractText Label="BACKGROUND">Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin.</AbstractText><AbstractText Label="OBJECTIVE">To assess whether FV is effective on walking impairment in a cohort of MS patients.</AbstractText><AbstractText Label="METHODS">We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of FV vs sham vibration in 20 RR MS patients. Ten patients received treatment with the active device and ten patients sham treatment. Demographical, clinical and gait instrumental data analysis have been collected for each patient at baseline (T0), after treatment (T1) and after three weeks of wash out (T2).</AbstractText><AbstractText Label="RESULTS">Both groups were clinically and demographically comparable. Treated patients showed significant improvements during the first right step (FRS) (p = 0.007), average stride lenght (ASL) (p = 0.012), double support right (DSRT) (p = 0.016) and left (DSLT) (p = 0.003) time. Non-treated patients didn't show any significance for any dynamic variables. Moreover, on posturographic measurements we registered only a trend towards significance in swing area with eyes open (SAEO) (p = 0.087). We also found in treated group significant improvements in FRT (p = 0.018); BBS (p = 0.037) and FSS scales (p = 0.038) between T1 and T0. Lastly, we found a significant inverse correlation in the treated group between disease duration and percentage of improvement for DSLT (r = - 0.775; p = 0.014) in T1 vs T0 and percentage of improvement of FSS, with an inverse correlation with both disease duration (r = - 0.775; p = 0.014) and AGE (r = - 0.733, p = 0.025) in T1 vs T0CONCLUSION: Our results suggest a beneficial effect of FV on walking impairment in MS patients suffering from spasticity and/or postural instability, which partially lasted until follow up.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Spina</LastName><ForeName>Emanuele</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Carotenuto</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Aceto</LastName><ForeName>Maria Gabriella</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Cerillo</LastName><ForeName>Ilaria</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Silvestre</LastName><ForeName>Francesco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Arace</LastName><ForeName>Francesco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Paone</LastName><ForeName>Paolo</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Orefice</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Iodice</LastName><ForeName>Rosa</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Restor Neurol Neurosci</MedlineTA><NlmUniqueID>9005499</NlmUniqueID><ISSNLinking>0922-6028</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005145" MajorTopicYN="N">Face</DescriptorName><QualifierName UI="Q000294" MajorTopicYN="Y">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007839" MajorTopicYN="N">Functional Laterality</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009069" MajorTopicYN="N">Movement Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000534" MajorTopicYN="Y">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014732" MajorTopicYN="N">Vibration</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016138" MajorTopicYN="N">Walking</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Multiple sclerosis</Keyword><Keyword MajorTopicYN="Y">focal vibrations</Keyword><Keyword MajorTopicYN="Y">gait analysis</Keyword><Keyword MajorTopicYN="Y">neurorehabilitation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>8</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27567760</ArticleId><ArticleId IdType="pii">RNN160665</ArticleId><ArticleId IdType="doi">10.3233/RNN-160665</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PosturoV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000629 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000629 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PosturoV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:27567760
|texte= The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:27567760" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a PosturoV1
| This area was generated with Dilib version V0.6.37. |  |