| Ident. | Authors (with country if any) | Title |
|---|
| 000430 (2010) |
Silvia Zucchelli ; Marta Codrich ; Federica Marcuzzi ; Milena Pinto ; Sandra Vilotti ; Marta Biagioli ; Isidro Ferrer ; Stefano Gustincich [Italie] | TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains |
| 000431 (2010) |
Wanli W. Smith [États-Unis] ; Zhaohui Liu ; Yideng Liang ; Naoki Masuda ; Debbie A. Swing ; Nancy A. Jenkins ; Neal G. Copeland ; Juan C. Troncoso ; Mikhail Pletnikov ; Ted M. Dawson ; Lee J. Martin ; Timothy H. Moran ; Michael K. Lee ; David R. Borchelt ; Christopher A. Ross [États-Unis] | Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse model |
| 000442 (2010) |
Di Sha [États-Unis] ; Lih-Shen Chin [États-Unis] ; Lian Li [États-Unis] | Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-B signaling |
| 000444 (2010) |
Mark R. Cookson ; Oliver Bandmann [Royaume-Uni] | Parkinson's disease: insights from pathways |
| 000445 (2010) |
Suzanne Lesage ; Etienne Patin ; Christel Condroyer ; Anne-Louise Leutenegger ; Ebba Lohmann ; Nir Giladi ; Anat Bar-Shira ; Soraya Belarbi ; Nassima Hecham ; Pierre Pollak [Suisse] ; Anne-Marie Ouvrard-Hernandez ; Soraya Bardien ; Jonathan Carr ; Traki Benhassine ; Hiroyuki Tomiyama ; Caroline Pirkevi ; Tarik Hamadouche ; Ccile Cazeneuve [France] ; A. Nazli Basak ; Nobutaka Hattori ; Alexandra Drr [France] ; Meriem Tazir ; Avi Orr-Urtreger ; Lluis Quintana-Murci ; Alexis Brice [France] ; Yves Agid [France] ; A.-M. Bonnet ; M. Borg ; A. Brice ; E. Broussolle ; Ph. Damier ; A. Deste ; A. Drr ; F. Durif ; E. Lohmann ; M. Martinez ; C. Penet ; Pierre Pollak [Suisse] ; Olivier Rascol [France] ; F. Tison ; C. Tranchant ; A. Troiano ; M. Vrin ; F. Viallet ; M. Vidailhet | Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans |
| 000446 (2010) |
Jue Chen [États-Unis] ; Lian Li [États-Unis] ; Lih-Shen Chin [États-Unis] | Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage |
| 000453 (2010) |
Matthew E. Gegg [Royaume-Uni] ; J. Mark Cooper ; Kai-Yin Chau ; Manuel Rojo ; Anthony H. V. Schapira ; Jan-Willem Taanman | Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy |
| 000459 (2010) |
Idit Ron [Israël] ; Debora Rapaport [Israël] ; Mia Horowitz [Israël] | Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease |
| 000462 (2010) |
Shoji Tsuji [Japon] | Genetics of neurodegenerative diseases: insights from high-throughput resequencing |
| 000466 (2010) |
Yien-Ming Kuo ; Zhishan Li ; Yun Jiao ; Nathalie Gaborit ; Amar K. Pani ; Bonnie M. Orrison ; Benoit G. Bruneau ; Benoit I. Giasson ; Richard J. Smeyne ; Michael D. Gershon ; Robert L. Nussbaum [États-Unis] | Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated -synuclein gene mutations precede central nervous system changes |
| 000469 (2010) |
Aleksandar Rakovic [Allemagne] ; Anne Grnewald [Allemagne] ; Philip Seibler [Allemagne] ; Alfredo Ramirez [Allemagne] ; Norman Kock [Allemagne] ; Slobodanka Orolicki [Allemagne] ; Katja Lohmann [Allemagne] ; Christine Klein [Allemagne] | Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients |
| 000470 (2010) |
Lena F. Burbulla ; Carina Schelling ; Hiroki Kato ; Doron Rapaport ; Dirk Woitalla ; Carola Schiesling ; Claudia Schulte ; Manu Sharma ; Thomas Illig ; Peter Bauer ; Stephan Jung ; Alfred Nordheim ; Ludger Schls ; Olaf Riess ; Rejko Krger [Allemagne] | Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis |
| 000474 (2010) |
Chenere P. Ramsey ; Elpida Tsika ; Harry Ischiropoulos ; Benoit I. Giasson [États-Unis] | DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human -syn toxicity |
| 000484 (2010) |
Charleen T. Chu [États-Unis] | A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease |
| 000487 (2010) |
Kanae Iijima-Ando [États-Unis] ; Lijuan Zhao ; Anthony Gatt ; Christopher Shenton ; Koichi Iijima [États-Unis] | A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration |
| 000860 (2009) |
Samareh Azeredo Da Silveira ; Bernard L. Schneider ; Carmen Cifuentes-Diaz [France] ; Daniel Sage ; Toufik Abbas-Terki ; Takeshi Iwatsubo ; Michal Unser [France] ; Patrick Aebischer [Suisse] | Phosphorylation does not prompt, nor prevent, the formation of -synuclein toxic species in a rat model of Parkinson's disease |
| 000862 (2009) |
Suzanne Lesage ; Alexis Brice [France] | Parkinson's disease: from monogenic forms to genetic susceptibility factors |
| 000865 (2009) |
Oliver Rothfuss ; Heike Fischer ; Takafumi Hasegawa ; Martina Maisel ; Petra Leitner ; Franziska Miesel ; Manu Sharma ; Antje Bornemann ; Daniela Berg ; Thomas Gasser ; Nadja Patenge [Allemagne] | Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair |
| 000869 (2009) |
Rosa M. Sancho [Royaume-Uni] ; Bernard M. H. Law [Royaume-Uni] ; Kirsten Harvey [Royaume-Uni] | Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways |
| 000870 (2009) |
Catherine Kielar ; Thomas M. Wishart ; Alice Palmer ; Sybille Dihanich ; Andrew M. Wong ; Shannon L. Macauley ; Chun-Hung Chan ; Mark S. Sands ; David A. Pearce ; Jonathan D. Cooper ; Thomas H. Gillingwater [Royaume-Uni] | Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease |
| 000871 (2009) |
Hsiuchen Chen [États-Unis] ; David C. Chan [États-Unis] | Mitochondrial dynamicsfusion, fission, movement, and mitophagyin neurodegenerative diseases |
| 000875 (2009) |
Katerina Venderova ; Ghassan Kabbach ; Elizabeth Abdel-Messih ; Yi Zhang ; Robin J. Parks ; Yuzuru Imai ; Stephan Gehrke ; Johnny Ngsee ; Matthew J. Lavoie ; Ruth S. Slack ; Yong Rao ; Zhuohua Zhang [États-Unis] ; Bingwei Lu ; M. Emdadul Haque [Canada] ; David S. Park [Canada] | Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease |
| 000876 (2009) |
Jose Bras ; Javier Simn-Snchez ; Monica Federoff ; Ana Morgadinho ; Cristina Januario ; Maria Ribeiro ; Luis Cunha ; Catarina Oliveira ; Andrew B. Singleton | Lack of replication of association between GIGYF2 variants and Parkinson disease |
| 000884 (2009) |
Lars Bertram [Allemagne] ; Rudolph E. Tanzi | Genome-wide association studies in Alzheimer's disease |
| 000887 (2009) |
Barbara Giovannone ; William G. Tsiaras ; Suzanne De La Monte ; Jan Klysik ; Corinne Lautier ; Galina Karashchuk ; Stefano Goldwurm ; Robert J. Smith | GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling |
| 000890 (2009) |
Kenneth D. Cronin ; Dongliang Ge ; Paul Manninger ; Colton Linnertz ; Anna Rossoshek ; Bonnie M. Orrison ; David J. Bernard ; Omar M. A. El-Agnaf ; Michael G. Schlossmacher ; Robert L. Nussbaum ; Ornit Chiba-Falek [États-Unis] | Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human -synuclein in transgenic mouse brain |
| 000897 (2009) |
Elena Rubio De La Torre ; Berta Luzn-Toro ; Irene Forte-Lago ; Adolfo Minguez-Castellanos ; Isidro Ferrer ; Sabine Hilfiker [Espagne] | Combined kinase inhibition modulates parkin inactivation |
| 000B89 (2008) |
Andreas Weihofen [États-Unis] ; Beth Ostaszewski [États-Unis] ; Yasufumi Minami ; Dennis J. Selkoe [États-Unis] | Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1 |
| 000B92 (2008) |
Jun Liang ; Cheryl Clark-Dixon ; Shaoxiao Wang ; Todd R. Flower ; Tara Williams-Hart ; Richard Zweig [États-Unis] ; Lucy C. Robinson ; Kelly Tatchell ; Stephan N. Witt [États-Unis] | Novel suppressors of -synuclein toxicity identified using yeast |
| 000B98 (2008) |
Yonghong Li [États-Unis] ; Andrew Grupe [États-Unis] ; Charles Rowland [États-Unis] ; Peter Holmans ; Ricardo Segurado ; Richard Abraham ; Lesley Jones ; Joseph Catanese [États-Unis] ; David Ross [États-Unis] ; Kevin Mayo ; Maribel Martinez ; Paul Hollingworth ; Alison Goate ; Nigel J. Cairns ; Brad A. Racette ; Joel S. Perlmutter ; Michael C. O'Donovan ; John C. Morris ; Carol Brayne ; David C. Rubinsztein ; Simon Lovestone ; Leon J. Thal ; Michael J. Owen ; Julie Williams | Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease |
| 000C12 (2008) |
Julien Chapuis ; Frdric Moisan ; Georges Mellick ; Alexis Elbaz ; Peter Silburn ; Florence Pasquier ; Didier Hannequin [France] ; Corinne Lendon ; Dominique Campion [France] ; Philippe Amouyel ; Jean-Charles Lambert [France] | Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease |
| 000C15 (2008) |
Tomoki Kuwahara ; Akihiko Koyama ; Shingo Koyama ; Sawako Yoshina ; Chang-Hong Ren ; Takeo Kato ; Shohei Mitani ; Takeshi Iwatsubo [Japon] | A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in -synuclein transgenic C. elegans |
| 000E88 (2007) |
Purnima Desai Sundar ; Chang-En Yu ; Weiva Sieh ; Ellen Steinbart ; Ralph M. Garruto ; Kiyomitsu Oyanagi ; Ulla-Katrina Craig ; Thomas D. Bird ; Ellen M. Wijsman ; Douglas R. Galasko [États-Unis] ; Gerard D. Schellenberg [États-Unis] | Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia |
| 000E89 (2007) |
Maria A. Graziewicz ; Rachelle J. Bienstock [États-Unis] ; William C. Copeland | The DNA polymerase Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2-deoxyguanosine |
| 000E94 (2007) |
Bobby Thomas [États-Unis] ; M. Flint Beal [États-Unis] | Parkinson's disease |
| 000E95 (2007) |
Bernard L. Schneider ; Corey R. Seehus ; Elizabeth E. Capowski ; Patrick Aebischer ; Su-Chun Zhang ; Clive N. Svendsen [États-Unis] | Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation |
| 000E97 (2007) |
Christine C. Stichel ; Xin-Ran Zhu ; Verian Bader ; Bettina Linnartz ; Saskia Schmidt ; Hermann Lbbert [Allemagne] | Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage |
| 000E98 (2007) |
Berta Luzn-Toro ; Elena Rubio De La Torre ; Asuncin Delgado ; Jordi Prez-Tur ; Sabine Hilfiker [Espagne] | Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation |
| 000F04 (2007) |
Andrew Grupe [Royaume-Uni] ; Richard Abraham ; Yonghong Li ; Charles Rowland ; Paul Hollingworth ; Angharad Morgan ; Luke Jehu ; Ricardo Segurado ; David Stone ; Eric Schadt ; Maha Karnoub ; Petra Nowotny ; Kristina Tacey ; Joseph Catanese ; John Sninsky ; Carol Brayne ; David Rubinsztein ; Michael Gill ; Brian Lawlor ; Simon Lovestone ; Peter Holmans ; Michael O'Donovan ; John C. Morris ; Leon Thal ; Alison Goate ; Michael J. Owen ; Julie Williams [Royaume-Uni] | Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants |
| 001151 (2006) |
Tara M. Caffrey ; Catharine Joachim [Royaume-Uni] ; Silvia Paracchini ; Margaret M. Esiri [Royaume-Uni] ; Richard Wade-Martins [Royaume-Uni] | Haplotype-specific expression of exon 10 at the human MAPT locus |
| 001155 (2006) |
Cornelia Hampe ; Hector Ardila-Osorio ; Margot Fournier ; Alexis Brice ; Olga Corti [France] | Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitinprotein ligase with monoubiquitylation capacity |
| 001186 (2006) |
Christian Johannes Gloeckner ; Norbert Kinkl ; Annette Schumacher ; Ralf J. Braun ; Eric O'Neill [Royaume-Uni] ; Thomas Meitinger ; Walter Kolch [Royaume-Uni] ; Holger Prokisch ; Marius Ueffing [Allemagne] | The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity |
| 001232 (2006) |
Monzy Thomas ; Jennifer M. Harrell [États-Unis] ; Yoshihiro Morishima [États-Unis] ; Hwei-Ming Peng [États-Unis] ; William B. Pratt [États-Unis] ; Andrew P. Lieberman [États-Unis] | Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction |
| 001258 (2006) |
Ikuko Mizuta ; Wataru Satake ; Yuko Nakabayashi ; Chiyomi Ito ; Satoko Suzuki ; Yoshio Momose ; Yoshitaka Nagai ; Akira Oka ; Hidetoshi Inoko ; Jiro Fukae ; Yuko Saito ; Motoji Sawabe ; Shigeo Murayama ; Mitsutoshi Yamamoto ; Nobutaka Hattori ; Miho Murata [Japon] ; Tatsushi Toda [Japon] | Multiple candidate gene analysis identifies α-synuclein as a susceptibility gene for sporadic Parkinson's disease |
| 001293 (2006) |
Charles E. Glatt [États-Unis] ; Angelika D. Wahner ; Daniel J. White [Royaume-Uni] ; Andres Ruiz-Linares [Royaume-Uni] ; Beate Ritz | Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women |
| 001355 (2006) |
Beisha Tang ; Hui Xiong [États-Unis] ; Ping Sun [États-Unis] ; Yuhu Zhang ; Danling Wang [États-Unis] ; Zhengmao Hu ; Zanhua Zhu ; Hong Ma [États-Unis] ; Qian Pan ; Jia-Hui Xia ; Kun Xia ; Zhuohua Zhang [États-Unis] | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease |
| 001407 (2005) |
Jin Xu [États-Unis] ; Nan Zhong ; Haoyong Wang ; Joshua E. Elias ; Christina Y. Kim ; Irina Woldman ; Christian Pifl ; Steven P. Gygi ; Changiz Geula [États-Unis] ; Bruce A. Yankner | The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis |
| 001465 (2005) |
Sonia Gandhi [Royaume-Uni] ; Nicholas W. Wood [Royaume-Uni] | Molecular pathogenesis of Parkinson's disease |
| 001488 (2005) |
Jessica C. Greene [États-Unis] ; Alexander J. Whitworth [États-Unis] ; Laurie A. Andrews [États-Unis] ; Tracey J. Parker [États-Unis] ; Leo J. Pallanck [États-Unis] | Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis |
| 001495 (2005) |
Sathya R. Sriram ; Xiaojie Li ; Han Seok Ko ; Kenny K. K. Chung ; Esther Wong [Singapour] ; Kah Leong Lim [Singapour] ; Valina L. Dawson ; Ted M. Dawson [États-Unis] | Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin |
| 001517 (2005) |
Lisa Skipper ; Yi Li ; Carine Bonnard ; Ratnagopal Pavanni ; Yuen Yih ; Eva Chua ; Wing-Kin Sung ; Louis Tan ; Meng-Cheong Wong ; Eng-King Tan ; Jianjun Liu [Singapour] | Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease |
