A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease
Identifieur interne : 001E18 ( Main/Exploration ); précédent : 001E17; suivant : 001E19A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease
Auteurs : H. Liu ; R. P. Iacono ; T. Schoonenberg ; S. Kuniyoshi ; J. BuchholzSource :
- Neurobiology of Disease [ 0969-9961 ] ; 1998.
Abstract
This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.
Url:
DOI: 10.1006/nbdi.1998.0222
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Liu</name><affiliation><wicri:noCountry code="subField">Loma Linda University Medical School</wicri:noCountry></affiliation></author><author><name sortKey="Iacono, R P" sort="Iacono, R P" uniqKey="Iacono R" first="R. P." last="Iacono">R. P. Iacono</name><affiliation><wicri:noCountry code="subField">Loma Linda University Medical School</wicri:noCountry></affiliation></author><author><name sortKey="Schoonenberg, T" sort="Schoonenberg, T" uniqKey="Schoonenberg T" first="T." last="Schoonenberg">T. Schoonenberg</name><affiliation><wicri:noCountry code="subField">92350</wicri:noCountry></affiliation></author><author><name sortKey="Kuniyoshi, S" sort="Kuniyoshi, S" uniqKey="Kuniyoshi S" first="S." last="Kuniyoshi">S. Kuniyoshi</name><affiliation><wicri:noCountry code="subField">Loma Linda University Medical School</wicri:noCountry></affiliation></author><author><name sortKey="Buchholz, J" sort="Buchholz, J" uniqKey="Buchholz J" first="J." last="Buchholz">J. Buchholz</name><affiliation><wicri:noCountry code="subField">Loma Linda University Medical School</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurobiology of Disease</title><title level="j" type="abbrev">YNBDI</title><idno type="ISSN">0969-9961</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="35">35</biblScope><biblScope unit="page" to="42">42</biblScope></imprint><idno type="ISSN">0969-9961</idno></series><idno type="istex">3A04297B6CEF15BF027E4BE7633FFE6A5960DE50</idno><idno type="DOI">10.1006/nbdi.1998.0222</idno><idno type="PII">S0969-9961(98)90222-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0969-9961</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Buchholz, J" sort="Buchholz, J" uniqKey="Buchholz J" first="J." last="Buchholz">J. Buchholz</name><name sortKey="Iacono, R P" sort="Iacono, R P" uniqKey="Iacono R" first="R. P." last="Iacono">R. P. Iacono</name><name sortKey="Kuniyoshi, S" sort="Kuniyoshi, S" uniqKey="Kuniyoshi S" first="S." last="Kuniyoshi">S. Kuniyoshi</name><name sortKey="Liu, H" sort="Liu, H" uniqKey="Liu H" first="H." last="Liu">H. Liu</name><name sortKey="Schoonenberg, T" sort="Schoonenberg, T" uniqKey="Schoonenberg T" first="T." last="Schoonenberg">T. Schoonenberg</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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