A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease
Identifieur interne : 001E72 ( Main/Corpus ); précédent : 001E71; suivant : 001E73A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease
Auteurs : H. Liu ; R. P. Iacono ; T. Schoonenberg ; S. Kuniyoshi ; J. BuchholzSource :
- Neurobiology of Disease [ 0969-9961 ] ; 1998.
Abstract
This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.
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DOI: 10.1006/nbdi.1998.0222
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title><author><name sortKey="Liu, H" sort="Liu, H" uniqKey="Liu H" first="H." last="Liu">H. Liu</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author><author><name sortKey="Iacono, R P" sort="Iacono, R P" uniqKey="Iacono R" first="R. P." last="Iacono">R. P. Iacono</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author><author><name sortKey="Schoonenberg, T" sort="Schoonenberg, T" uniqKey="Schoonenberg T" first="T." last="Schoonenberg">T. Schoonenberg</name><affiliation><mods:affiliation>Loma Linda Neuroscience & Movement Disorder Clinic, Loma Linda, California, 92350</mods:affiliation></affiliation></author><author><name sortKey="Kuniyoshi, S" sort="Kuniyoshi, S" uniqKey="Kuniyoshi S" first="S." last="Kuniyoshi">S. Kuniyoshi</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author><author><name sortKey="Buchholz, J" sort="Buchholz, J" uniqKey="Buchholz J" first="J." last="Buchholz">J. Buchholz</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3A04297B6CEF15BF027E4BE7633FFE6A5960DE50</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1006/nbdi.1998.0222</idno><idno type="url">https://api.istex.fr/document/3A04297B6CEF15BF027E4BE7633FFE6A5960DE50/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title><author><name sortKey="Liu, H" sort="Liu, H" uniqKey="Liu H" first="H." last="Liu">H. Liu</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author><author><name sortKey="Iacono, R P" sort="Iacono, R P" uniqKey="Iacono R" first="R. P." last="Iacono">R. P. Iacono</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author><author><name sortKey="Schoonenberg, T" sort="Schoonenberg, T" uniqKey="Schoonenberg T" first="T." last="Schoonenberg">T. Schoonenberg</name><affiliation><mods:affiliation>Loma Linda Neuroscience & Movement Disorder Clinic, Loma Linda, California, 92350</mods:affiliation></affiliation></author><author><name sortKey="Kuniyoshi, S" sort="Kuniyoshi, S" uniqKey="Kuniyoshi S" first="S." last="Kuniyoshi">S. Kuniyoshi</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author><author><name sortKey="Buchholz, J" sort="Buchholz, J" uniqKey="Buchholz J" first="J." last="Buchholz">J. Buchholz</name><affiliation><mods:affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurobiology of Disease</title><title level="j" type="abbrev">YNBDI</title><idno type="ISSN">0969-9961</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="35">35</biblScope><biblScope unit="page" to="42">42</biblScope></imprint><idno type="ISSN">0969-9961</idno></series><idno type="istex">3A04297B6CEF15BF027E4BE7633FFE6A5960DE50</idno><idno type="DOI">10.1006/nbdi.1998.0222</idno><idno type="PII">S0969-9961(98)90222-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0969-9961</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>H. Liu</name><affiliations><json:string>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</json:string></affiliations></json:item><json:item><name>R.P. Iacono</name><affiliations><json:string>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</json:string></affiliations></json:item><json:item><name>T. Schoonenberg</name><affiliations><json:string>Loma Linda Neuroscience & Movement Disorder Clinic, Loma Linda, California, 92350</json:string></affiliations></json:item><json:item><name>S. Kuniyoshi</name><affiliations><json:string>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</json:string></affiliations></json:item><json:item><name>J. Buchholz</name><affiliations><json:string>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><abstract>This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.</abstract><qualityIndicators><score>6.614</score><pdfVersion>1.2</pdfVersion><pdfPageSize>540 x 713 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1130</abstractCharCount><pdfWordCount>4586</pdfWordCount><pdfCharCount>28786</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>169</abstractWordCount></qualityIndicators><title>A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title><pii><json:string>S0969-9961(98)90222-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>6</volume><pii><json:string>S0969-9961(00)X0018-6</json:string></pii><pages><last>42</last><first>35</first></pages><issn><json:string>0969-9961</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Neurobiology of Disease</title><publicationDate>1999</publicationDate></host><categories><wos><json:string>CLINICAL NEUROLOGY</json:string><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1998</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1006/nbdi.1998.0222</json:string></doi><id>3A04297B6CEF15BF027E4BE7633FFE6A5960DE50</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3A04297B6CEF15BF027E4BE7633FFE6A5960DE50/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3A04297B6CEF15BF027E4BE7633FFE6A5960DE50/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3A04297B6CEF15BF027E4BE7633FFE6A5960DE50/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1999</date></publicationStmt><notesStmt><note>A. G. GiomanT. W. RalNies, ASP. Taylor</note><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title><author><persName><forename type="first">H.</forename><surname>Liu</surname></persName><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation></author><author><persName><forename type="first">R.P.</forename><surname>Iacono</surname></persName><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation></author><author><persName><forename type="first">T.</forename><surname>Schoonenberg</surname></persName><affiliation>Loma Linda Neuroscience & Movement Disorder Clinic, Loma Linda, California, 92350</affiliation></author><author><persName><forename type="first">S.</forename><surname>Kuniyoshi</surname></persName><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation></author><author><persName><forename type="first">J.</forename><surname>Buchholz</surname></persName><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation></author></analytic><monogr><title level="j">Neurobiology of Disease</title><title level="j" type="abbrev">YNBDI</title><idno type="pISSN">0969-9961</idno><idno type="PII">S0969-9961(00)X0018-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="35">35</biblScope><biblScope unit="page" to="42">42</biblScope></imprint></monogr><idno type="istex">3A04297B6CEF15BF027E4BE7633FFE6A5960DE50</idno><idno type="DOI">10.1006/nbdi.1998.0222</idno><idno type="PII">S0969-9961(98)90222-4</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.</p></abstract></profileDesc><revisionDesc><change when="1998-11-02">Registration</change><change when="1998-10-28">Modified</change><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3A04297B6CEF15BF027E4BE7633FFE6A5960DE50/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YNBDI</jid><aid>90222</aid><ce:pii>S0969-9961(98)90222-4</ce:pii><ce:doi>10.1006/nbdi.1998.0222</ce:doi><ce:copyright type="full-transfer" year="1999">Academic Press</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>A. G. GiomanT. W. RalNies, ASP. Taylor</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</ce:title><ce:author-group><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Liu</ce:surname><ce:cross-ref refid="NBDI.1998.0222A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>R.P.</ce:given-name><ce:surname>Iacono</ce:surname><ce:cross-ref refid="NBDI.1998.0222A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="NBDI.1998.0222A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.</ce:given-name><ce:surname>Schoonenberg</ce:surname><ce:cross-ref refid="NBDI.1998.0222A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Kuniyoshi</ce:surname><ce:cross-ref refid="NBDI.1998.0222A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Buchholz</ce:surname><ce:cross-ref refid="NBDI.1998.0222A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="NBDI.1998.0222A1"><ce:label>a</ce:label><ce:textfn>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</ce:textfn></ce:affiliation><ce:affiliation id="NBDI.1998.0222A2"><ce:label>b</ce:label><ce:textfn>Loma Linda Neuroscience & Movement Disorder Clinic, Loma Linda, California, 92350</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="1" month="5" year="1998"></ce:date-received><ce:date-revised day="28" month="10" year="1998"></ce:date-revised><ce:date-accepted day="2" month="11" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-<ce:italic>O</ce:italic>-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Liu</namePart><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.P.</namePart><namePart type="family">Iacono</namePart><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Schoonenberg</namePart><affiliation>Loma Linda Neuroscience & Movement Disorder Clinic, Loma Linda, California, 92350</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kuniyoshi</namePart><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Buchholz</namePart><affiliation>Department of Pharmacology/Physiology, Department of Surgery, Loma Linda University Medical School</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><dateValid encoding="w3cdtf">1998-11-02</dateValid><dateModified encoding="w3cdtf">1998-10-28</dateModified><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS). Cerebrospinal fluid from the lateral ventricle was collected from 50 patients with idiopathic Parkinson's disease of PD-A and PD-B. Levels of monoamine neurotransmitters and metabolites were determined using high performance liquid chromatography. We have found that (1) 5-hydroxylindoleacetic acid (5-HIAA) level is significantly lower in PD-B than in PD-A; (2) 5-HIAA level is inversely associated with score of part one of United Parkinson's Disease Rating Score (UPDRS); (3) 5-HIAA level is inversely associated with score of part four of UPDRS; (4) 3-O-methyldopa (3-OMD) level is positively associated with levodopa failure syndrome (LDFS) assessed by part four of UPDRS and inversely associates with 5-HIAA. From these data, it can be inferred that serotonergic activity is decreased in PD-B to a greater extent than in PD-A and that decreased serotonergic activity plays a role in LDFS.</abstract><note>A. G. GiomanT. W. RalNies, ASP. 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