Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study
Identifieur interne : 001094 ( Main/Exploration ); précédent : 001093; suivant : 001095Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study
Auteurs : Hal H. Atkinson [États-Unis] ; Caterina Rosano [États-Unis] ; Eleanor M. Simonsick [États-Unis] ; Jeff D. Williamson [États-Unis] ; Cralen Davis ; Walter T. Ambrosius ; Stephen R. Rapp ; Matteo Cesari ; Anne B. Newman [États-Unis] ; Tamara B. Harris [États-Unis] ; Susan M. Rubin ; Kristine Yaffe ; Suzanne Satterfield ; Stephen B. Kritchevsky [États-Unis]Source :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 2007-08.
Abstract
Background. Emerging evidence indicates an association between cognitive function and physical performance in late life. This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults. Methods. Measures of global cognitive function (Modified Mini Mental State Examination [3MS]) and executive control function (ECF) (a clock drawing task [CLOX 1] and the 15-item Executive Interview [EXIT 15]) were obtained in the Health, Aging, and Body Composition Study in 1999–2000. Gait-speed (meters/second) was assessed over 20 meters at usual pace. Using a mixed model, we assessed the relationship between baseline cognitive function and gait-speed change over 3 years. Results. Two thousand, three hundred forty-nine older adults (mean age 75.6 ± 2.9 years) completed the assessments. After adjustment for baseline gait speed, a 1-standard-deviation (SD) lower performance on each cognitive test was associated with greater gait-speed decline over 3 years: 0.016 m/s for the 3MS (SD = 8.1), 0.009 m/s for CLOX 1 (SD = 2.4), and 0.012 m/s for EXIT 15 (SD = 4.1) (p <.0005 for all). After adjustment for comorbidities, the effect size was attenuated for 3MS and CLOX 1, and the association for EXIT 15 was no longer significant. Depression score was most strongly associated with the EXIT 15 effect reduction. Conclusion. Global and executive cognitive functions predict declines in gait speed. The association of ECF with gait speed decline is attenuated by comorbid conditions, particularly depression. Elucidation of the mechanisms underlying these associations may point to new pathways for the treatment of physical decline associated with diminished cognitive function.
Url:
DOI: 10.1093/gerona/62.8.844
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Williamson</name></author><author><name sortKey="Davis, Cralen" sort="Davis, Cralen" uniqKey="Davis C" first="Cralen" last="Davis">Cralen Davis</name></author><author><name sortKey="Ambrosius, Walter T" sort="Ambrosius, Walter T" uniqKey="Ambrosius W" first="Walter T." last="Ambrosius">Walter T. Ambrosius</name></author><author><name sortKey="Rapp, Stephen R" sort="Rapp, Stephen R" uniqKey="Rapp S" first="Stephen R." last="Rapp">Stephen R. Rapp</name></author><author><name sortKey="Cesari, Matteo" sort="Cesari, Matteo" uniqKey="Cesari M" first="Matteo" last="Cesari">Matteo Cesari</name></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. 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Atkinson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D. Pepper Older Americans Independence Center and Roena Kulynych Center for Memory and Cognition Research, Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Address correspondence to Hal H. Atkinson, MD, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, Division of Geriatrics, University of Pittsburgh Institute on Aging</wicri:cityArea></affiliation></author><author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, National Institute on Aging, Baltimore and Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Williamson, Jeff D" sort="Williamson, Jeff D" uniqKey="Williamson J" first="Jeff D." last="Williamson">Jeff D. Williamson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D. Pepper Older Americans Independence Center and Roena Kulynych Center for Memory and Cognition Research, Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Davis, Cralen" sort="Davis, Cralen" uniqKey="Davis C" first="Cralen" last="Davis">Cralen Davis</name></author><author><name sortKey="Ambrosius, Walter T" sort="Ambrosius, Walter T" uniqKey="Ambrosius W" first="Walter T." last="Ambrosius">Walter T. Ambrosius</name></author><author><name sortKey="Rapp, Stephen R" sort="Rapp, Stephen R" uniqKey="Rapp S" first="Stephen R." last="Rapp">Stephen R. Rapp</name></author><author><name sortKey="Cesari, Matteo" sort="Cesari, Matteo" uniqKey="Cesari M" first="Matteo" last="Cesari">Matteo Cesari</name><affiliation><wicri:noCountry code="subField">Gainesville</wicri:noCountry></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, Division of Geriatrics, University of Pittsburgh Institute on Aging</wicri:cityArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, National Institute on Aging, Baltimore and Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Rubin, Susan M" sort="Rubin, Susan M" uniqKey="Rubin S" first="Susan M." last="Rubin">Susan M. Rubin</name></author><author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name></author><author><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name><affiliation><wicri:noCountry code="subField">Memphis</wicri:noCountry></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D. Pepper Older Americans Independence Center and Roena Kulynych Center for Memory and Cognition Research, Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title><title level="j" type="abbrev">J Gerontol A Biol Sci Med Sci</title><idno type="ISSN">1079-5006</idno><idno type="eISSN">1758-535X</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2007-08">2007-08</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="844">844</biblScope><biblScope unit="page" to="850">850</biblScope></imprint><idno type="ISSN">1079-5006</idno></series><idno type="istex">6194D16518EA16C6D2F85E7B696D498D0097DDD2</idno><idno type="DOI">10.1093/gerona/62.8.844</idno><idno type="href">844</idno><idno type="local">844</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1079-5006</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Emerging evidence indicates an association between cognitive function and physical performance in late life. This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults. Methods. Measures of global cognitive function (Modified Mini Mental State Examination [3MS]) and executive control function (ECF) (a clock drawing task [CLOX 1] and the 15-item Executive Interview [EXIT 15]) were obtained in the Health, Aging, and Body Composition Study in 1999–2000. Gait-speed (meters/second) was assessed over 20 meters at usual pace. Using a mixed model, we assessed the relationship between baseline cognitive function and gait-speed change over 3 years. Results. Two thousand, three hundred forty-nine older adults (mean age 75.6 ± 2.9 years) completed the assessments. After adjustment for baseline gait speed, a 1-standard-deviation (SD) lower performance on each cognitive test was associated with greater gait-speed decline over 3 years: 0.016 m/s for the 3MS (SD = 8.1), 0.009 m/s for CLOX 1 (SD = 2.4), and 0.012 m/s for EXIT 15 (SD = 4.1) (p <.0005 for all). After adjustment for comorbidities, the effect size was attenuated for 3MS and CLOX 1, and the association for EXIT 15 was no longer significant. Depression score was most strongly associated with the EXIT 15 effect reduction. Conclusion. Global and executive cognitive functions predict declines in gait speed. The association of ECF with gait speed decline is attenuated by comorbid conditions, particularly depression. Elucidation of the mechanisms underlying these associations may point to new pathways for the treatment of physical decline associated with diminished cognitive function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Maryland</li><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Ambrosius, Walter T" sort="Ambrosius, Walter T" uniqKey="Ambrosius W" first="Walter T." last="Ambrosius">Walter T. Ambrosius</name><name sortKey="Cesari, Matteo" sort="Cesari, Matteo" uniqKey="Cesari M" first="Matteo" last="Cesari">Matteo Cesari</name><name sortKey="Davis, Cralen" sort="Davis, Cralen" uniqKey="Davis C" first="Cralen" last="Davis">Cralen Davis</name><name sortKey="Rapp, Stephen R" sort="Rapp, Stephen R" uniqKey="Rapp S" first="Stephen R." last="Rapp">Stephen R. Rapp</name><name sortKey="Rubin, Susan M" sort="Rubin, Susan M" uniqKey="Rubin S" first="Susan M." last="Rubin">Susan M. Rubin</name><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Atkinson, Hal H" sort="Atkinson, Hal H" uniqKey="Atkinson H" first="Hal H." last="Atkinson">Hal H. Atkinson</name></region><name sortKey="Atkinson, Hal H" sort="Atkinson, Hal H" uniqKey="Atkinson H" first="Hal H." last="Atkinson">Hal H. Atkinson</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><name sortKey="Williamson, Jeff D" sort="Williamson, Jeff D" uniqKey="Williamson J" first="Jeff D." last="Williamson">Jeff D. Williamson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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