Bioenergetics and the epigenome: Interface between the environment and genes in common diseases
Identifieur interne : 000799 ( Main/Exploration ); précédent : 000798; suivant : 000800Bioenergetics and the epigenome: Interface between the environment and genes in common diseases
Auteurs : Douglas C. Wallace [États-Unis]Source :
- Developmental Disabilities Research Reviews [ 1940-5510 ] ; 2010-06.
English descriptors
Abstract
Extensive efforts have been directed at using genome‐wide association studies (GWAS) to identify the genes responsible for common metabolic and degenerative diseases, cancer, and aging, but with limited success. While environmental factors have been evoked to explain this conundrum, the nature of these environmental factors remains unexplained. The availability of and demands for energy constitute one of the most important aspects of the environment. The flow of energy through the cell is primarily mediated by the mitochondrion, which oxidizes reducing equivalents from hydrocarbons via acetyl‐CoA, NADH + H+, and FADH2 to generate ATP through oxidative phosphorylation (OXPHOS). The mitochondrial genome encompasses hundreds of nuclear DNA (nDNA)‐encoded genes plus 37 mitochondrial DNA (mtDNA)‐encoded genes. Although the mtDNA has a high mutation rate, only milder, potentially adaptive mutations are introduced into the population through female oocytes. In contrast, nDNA‐encoded bioenergetic genes have a low mutation rate. However, their expression is modulated by histone phosphorylation and acetylation using mitochondrially‐generated ATP and acetyl‐CoA, which permits increased gene expression, growth, and reproduction when calories are abundant. Phosphorylation, acetylaton, and cellular redox state also regulate most signal transduction pathways and activities of multiple transcription factors. Thus, mtDNA mutations provide heritable and stable adaptation to regional differences while mitochondrially‐mediated changes in the epigenome permit reversible modulation of gene expression in response to fluctuations in the energy environment. The most common genomic changes that interface with the environment and cause complex disease must, therefore, be mitochondrial and epigenomic in origin. © 2010 Wiley‐Liss, Inc. Dev Disabil Res Rev 2010;16:114–119.
Url:
DOI: 10.1002/ddrr.113
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bioenergetics and the epigenome: Interface between the environment and genes in common diseases</title>
<author><name sortKey="Wallace, Douglas C" sort="Wallace, Douglas C" uniqKey="Wallace D" first="Douglas C." last="Wallace">Douglas C. Wallace</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:718C5AF0F6ECBFD7FCAE09A04F872E3FB75097D4</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/ddrr.113</idno>
<idno type="url">https://api.istex.fr/document/718C5AF0F6ECBFD7FCAE09A04F872E3FB75097D4/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002079</idno>
<idno type="wicri:Area/Main/Curation">001D78</idno>
<idno type="wicri:Area/Main/Exploration">000799</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Bioenergetics and the epigenome: Interface between the environment and genes in common diseases</title>
<author><name sortKey="Wallace, Douglas C" sort="Wallace, Douglas C" uniqKey="Wallace D" first="Douglas C." last="Wallace">Douglas C. Wallace</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>The Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Developmental Disabilities Research Reviews</title>
<title level="j" type="abbrev">Dev Disabil Res Revs</title>
<idno type="ISSN">1940-5510</idno>
<idno type="eISSN">1940-5529</idno>
<imprint><publisher>Wiley Subscription Services, Inc., a Wiley company</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2010-06">2010-06</date>
<biblScope unit="volume">16</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="114">114</biblScope>
<biblScope unit="page" to="119">119</biblScope>
</imprint>
<idno type="ISSN">1940-5510</idno>
</series>
<idno type="istex">718C5AF0F6ECBFD7FCAE09A04F872E3FB75097D4</idno>
<idno type="DOI">10.1002/ddrr.113</idno>
<idno type="ArticleID">DDRR113</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1940-5510</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>bioenergetics</term>
<term>complex disease</term>
<term>epigenome</term>
<term>mitochondria</term>
<term>signal transduction</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Extensive efforts have been directed at using genome‐wide association studies (GWAS) to identify the genes responsible for common metabolic and degenerative diseases, cancer, and aging, but with limited success. While environmental factors have been evoked to explain this conundrum, the nature of these environmental factors remains unexplained. The availability of and demands for energy constitute one of the most important aspects of the environment. The flow of energy through the cell is primarily mediated by the mitochondrion, which oxidizes reducing equivalents from hydrocarbons via acetyl‐CoA, NADH + H+, and FADH2 to generate ATP through oxidative phosphorylation (OXPHOS). The mitochondrial genome encompasses hundreds of nuclear DNA (nDNA)‐encoded genes plus 37 mitochondrial DNA (mtDNA)‐encoded genes. Although the mtDNA has a high mutation rate, only milder, potentially adaptive mutations are introduced into the population through female oocytes. In contrast, nDNA‐encoded bioenergetic genes have a low mutation rate. However, their expression is modulated by histone phosphorylation and acetylation using mitochondrially‐generated ATP and acetyl‐CoA, which permits increased gene expression, growth, and reproduction when calories are abundant. Phosphorylation, acetylaton, and cellular redox state also regulate most signal transduction pathways and activities of multiple transcription factors. Thus, mtDNA mutations provide heritable and stable adaptation to regional differences while mitochondrially‐mediated changes in the epigenome permit reversible modulation of gene expression in response to fluctuations in the energy environment. The most common genomic changes that interface with the environment and cause complex disease must, therefore, be mitochondrial and epigenomic in origin. © 2010 Wiley‐Liss, Inc. Dev Disabil Res Rev 2010;16:114–119.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Wallace, Douglas C" sort="Wallace, Douglas C" uniqKey="Wallace D" first="Douglas C." last="Wallace">Douglas C. Wallace</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000799 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000799 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:718C5AF0F6ECBFD7FCAE09A04F872E3FB75097D4 |texte= Bioenergetics and the epigenome: Interface between the environment and genes in common diseases }}
This area was generated with Dilib version V0.6.23. |