Light and electron microscopic autoradiography of substantia nigra of rat after intraventricular administration of tritium labelled norepinephrine, dopamine, serotonin and the precursors
Identifieur interne : 002D40 ( Main/Curation ); précédent : 002D39; suivant : 002D41Light and electron microscopic autoradiography of substantia nigra of rat after intraventricular administration of tritium labelled norepinephrine, dopamine, serotonin and the precursors
Auteurs : J. Parizek [Allemagne] ; R. Hassler [Allemagne] ; J. Bak [Allemagne]Source :
- Zeitschrift für Zellforschung und Mikroskopische Anatomie [ 0044-3794 ] ; 1971-03-01.
Abstract
Summary: In autoradiographies of substantia nigra in rat, it has been observed that after intraventricular injections of 3H-dopamine and 3H-norepinephrine respectively the silvergrains are accumulated in nigra neurons and their dendritic branches. The incorporation was more pronounced in the case of 3H-norepinephrine than 3H-dopamine. This seems to indicate that exogenous norepinephrine may have stronger affinity to nigra neurons and their dendrites than exogenous dopamine. In addition, some 3H-dopamine and 3H-norepinephrine labelled nerve terminals were observed in axo-dendritic synapses. In contrast to these data, 3H-5HTP and 3H-5HT administration showed almost all silver grains accumulated in the neuropil when observed in light microscopic autoradiography. Electron micrographs further reveal that the incorporation of 3H-5HTP and 3H-5HT was mostly within axo-dendritic boutons with more frequent dense core vesicles. These data again strongly suggest that substantia nigra receives a large number of serotoninergic fibres forming axo-dendritic synapses which may play an important role in modulation of substantia nigra function.
Url:
DOI: 10.1007/BF00330222
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<front><div type="abstract" xml:lang="en">Summary: In autoradiographies of substantia nigra in rat, it has been observed that after intraventricular injections of 3H-dopamine and 3H-norepinephrine respectively the silvergrains are accumulated in nigra neurons and their dendritic branches. The incorporation was more pronounced in the case of 3H-norepinephrine than 3H-dopamine. This seems to indicate that exogenous norepinephrine may have stronger affinity to nigra neurons and their dendrites than exogenous dopamine. In addition, some 3H-dopamine and 3H-norepinephrine labelled nerve terminals were observed in axo-dendritic synapses. In contrast to these data, 3H-5HTP and 3H-5HT administration showed almost all silver grains accumulated in the neuropil when observed in light microscopic autoradiography. Electron micrographs further reveal that the incorporation of 3H-5HTP and 3H-5HT was mostly within axo-dendritic boutons with more frequent dense core vesicles. These data again strongly suggest that substantia nigra receives a large number of serotoninergic fibres forming axo-dendritic synapses which may play an important role in modulation of substantia nigra function.</div>
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