Light and electron microscopic autoradiography of substantia nigra of rat after intraventricular administration of tritium labelled norepinephrine, dopamine, serotonin and the precursors
Identifieur interne : 002D40 ( Main/Curation ); précédent : 002D39; suivant : 002D41Light and electron microscopic autoradiography of substantia nigra of rat after intraventricular administration of tritium labelled norepinephrine, dopamine, serotonin and the precursors
Auteurs : J. Parizek [Allemagne] ; R. Hassler [Allemagne] ; J. Bak [Allemagne]Source :
- Zeitschrift für Zellforschung und Mikroskopische Anatomie [ 0044-3794 ] ; 1971-03-01.
Abstract
Summary: In autoradiographies of substantia nigra in rat, it has been observed that after intraventricular injections of 3H-dopamine and 3H-norepinephrine respectively the silvergrains are accumulated in nigra neurons and their dendritic branches. The incorporation was more pronounced in the case of 3H-norepinephrine than 3H-dopamine. This seems to indicate that exogenous norepinephrine may have stronger affinity to nigra neurons and their dendrites than exogenous dopamine. In addition, some 3H-dopamine and 3H-norepinephrine labelled nerve terminals were observed in axo-dendritic synapses. In contrast to these data, 3H-5HTP and 3H-5HT administration showed almost all silver grains accumulated in the neuropil when observed in light microscopic autoradiography. Electron micrographs further reveal that the incorporation of 3H-5HTP and 3H-5HT was mostly within axo-dendritic boutons with more frequent dense core vesicles. These data again strongly suggest that substantia nigra receives a large number of serotoninergic fibres forming axo-dendritic synapses which may play an important role in modulation of substantia nigra function.
Url:
DOI: 10.1007/BF00330222
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Light and electron microscopic autoradiography of substantia nigra of rat after intraventricular administration of tritium labelled norepinephrine, dopamine, serotonin and the precursors</title><author><name sortKey="Parizek, J" sort="Parizek, J" uniqKey="Parizek J" first="J." last="Parizek">J. Parizek</name><affiliation wicri:level="1"><mods:affiliation>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Deutschland</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M.</wicri:regionArea></affiliation></author><author><name sortKey="Hassler, R" sort="Hassler, R" uniqKey="Hassler R" first="R." last="Hassler">R. Hassler</name><affiliation wicri:level="1"><mods:affiliation>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Deutschland</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M.</wicri:regionArea></affiliation></author><author><name sortKey="Bak, J" sort="Bak, J" uniqKey="Bak J" first="J." last="Bak">J. Bak</name><affiliation wicri:level="1"><mods:affiliation>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Deutschland</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. 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Parizek</name><affiliation wicri:level="1"><mods:affiliation>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Deutschland</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M.</wicri:regionArea></affiliation></author><author><name sortKey="Hassler, R" sort="Hassler, R" uniqKey="Hassler R" first="R." last="Hassler">R. Hassler</name><affiliation wicri:level="1"><mods:affiliation>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Deutschland</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M.</wicri:regionArea></affiliation></author><author><name sortKey="Bak, J" sort="Bak, J" uniqKey="Bak J" first="J." last="Bak">J. Bak</name><affiliation wicri:level="1"><mods:affiliation>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Deutschland</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M.</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Zeitschrift für Zellforschung und Mikroskopische Anatomie</title><title level="j" type="abbrev">Z. Zellforsch.</title><idno type="ISSN">0044-3794</idno><idno type="eISSN">1432-0878</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1971-03-01">1971-03-01</date><biblScope unit="volume">115</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="137">137</biblScope><biblScope unit="page" to="148">148</biblScope></imprint><idno type="ISSN">0044-3794</idno></series><idno type="istex">B9E8F08C6D03A2F5DADAAF596775CD75A4DA5AA8</idno><idno type="DOI">10.1007/BF00330222</idno><idno type="ArticleID">Art13</idno><idno type="ArticleID">BF00330222</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0044-3794</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: In autoradiographies of substantia nigra in rat, it has been observed that after intraventricular injections of 3H-dopamine and 3H-norepinephrine respectively the silvergrains are accumulated in nigra neurons and their dendritic branches. The incorporation was more pronounced in the case of 3H-norepinephrine than 3H-dopamine. This seems to indicate that exogenous norepinephrine may have stronger affinity to nigra neurons and their dendrites than exogenous dopamine. In addition, some 3H-dopamine and 3H-norepinephrine labelled nerve terminals were observed in axo-dendritic synapses. In contrast to these data, 3H-5HTP and 3H-5HT administration showed almost all silver grains accumulated in the neuropil when observed in light microscopic autoradiography. Electron micrographs further reveal that the incorporation of 3H-5HTP and 3H-5HT was mostly within axo-dendritic boutons with more frequent dense core vesicles. These data again strongly suggest that substantia nigra receives a large number of serotoninergic fibres forming axo-dendritic synapses which may play an important role in modulation of substantia nigra function.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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