MPTP, impairment of motor performance and amine accumulation in Macaca fasicularis
Identifieur interne : 002D39 ( Main/Curation ); précédent : 002D38; suivant : 002D40MPTP, impairment of motor performance and amine accumulation in Macaca fasicularis
Auteurs : Gregory L. Willis ; Julian Savulescu ; Malcolm K. Horne ; Graeme C. SmithSource :
- Brain Research Bulletin [ 0361-9230 ] ; 1986.
Abstract
The selective neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was injected (IV) into monkeys (Macaca fasicularis) in two different injection regimes. With the small dose regime, one monkey was injected with 0.25 mg/kg, every other day, over a 16 day period. In the large dose regime, another monkey was injected with 0.5 mg/kg every other day, over an 8 day period. While the time required for drug delivery was varied between animals, the total dose delivered was 2 mg/kg in both animals. Before, during and for 14 days after the course of drug administration both animals were assessed on several motor function tests. The animal receiving the small dose regime showed normal motor performance on all tests for the duration of the study, however, the monkey receiving the large dose regime displayed progressive akinesia, muscular rigidity and aphagia. In fact, impairment was so severe that this animal had to be force fed and maintained with daily oral L-dopa. Fluorescent histochemical assessment of forebrain in both monkeys revealed that striatal tissue was totally devoid of fluorescence in both cases. Large, swollen axons in the internal capsule, hypothalamus and midbrain were visible only in the severely impaired animal. These results suggest that, as with other neurotoxins, degeneration associated increases in amines may be important in the aetiology of Parkinson-like motor impairment produced by selective neurotoxins.
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DOI: 10.1016/0361-9230(87)90165-1
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Julian Savulescu<affiliation><mods:affiliation>Monash University, Department of Psychological Medicine, Prince Henry's Hospital Melbourne, Victoria, Australia 3004</mods:affiliation><wicri:noCountry code="subField">Australia 3004</wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Neurophysiology, Alfred Hospital Prahran, Victoria, Australia 3181</mods:affiliation><wicri:noCountry code="subField">Australia 3181</wicri:noCountry></affiliation><affiliation><mods:affiliation>Monash University, Department of Psychological Medicine, Prince Henry's Hospital Melbourne, Victoria, Australia 3004</mods:affiliation><wicri:noCountry code="subField">Australia 3004</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>MPTP, impairment of motor performance and amine accumulation in Macaca fasicularis</title><author><name sortKey="Willis, Gregory L" sort="Willis, Gregory L" uniqKey="Willis G" first="Gregory L." last="Willis">Gregory L. Willis</name></author><author><name sortKey="Savulescu, Julian" sort="Savulescu, Julian" uniqKey="Savulescu J" first="Julian" last="Savulescu">Julian Savulescu</name><affiliation><mods:affiliation>Monash University, Department of Psychological Medicine, Prince Henry's Hospital Melbourne, Victoria, Australia 3004</mods:affiliation><wicri:noCountry code="subField">Australia 3004</wicri:noCountry></affiliation></author><author><name sortKey="Horne, Malcolm K" sort="Horne, Malcolm K" uniqKey="Horne M" first="Malcolm K." last="Horne">Malcolm K. Horne</name><affiliation><mods:affiliation>Clinical Neurophysiology, Alfred Hospital Prahran, Victoria, Australia 3181</mods:affiliation><wicri:noCountry code="subField">Australia 3181</wicri:noCountry></affiliation></author><author><name sortKey="Smith, Graeme C" sort="Smith, Graeme C" uniqKey="Smith G" first="Graeme C." last="Smith">Graeme C. Smith</name><affiliation><mods:affiliation>Monash University, Department of Psychological Medicine, Prince Henry's Hospital Melbourne, Victoria, Australia 3004</mods:affiliation><wicri:noCountry code="subField">Australia 3004</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1825126A88D3DC9E27A819C005A1542CAA55C6BC</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1016/0361-9230(87)90165-1</idno><idno type="url">https://api.istex.fr/document/1825126A88D3DC9E27A819C005A1542CAA55C6BC/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">003138</idno><idno type="wicri:Area/Main/Curation">002D39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">MPTP, impairment of motor performance and amine accumulation in Macaca fasicularis</title><author><name sortKey="Willis, Gregory L" sort="Willis, Gregory L" uniqKey="Willis G" first="Gregory L." last="Willis">Gregory L. Willis</name></author><author><name sortKey="Savulescu, Julian" sort="Savulescu, Julian" uniqKey="Savulescu J" first="Julian" last="Savulescu">Julian Savulescu</name><affiliation><mods:affiliation>Monash University, Department of Psychological Medicine, Prince Henry's Hospital Melbourne, Victoria, Australia 3004</mods:affiliation><wicri:noCountry code="subField">Australia 3004</wicri:noCountry></affiliation></author><author><name sortKey="Horne, Malcolm K" sort="Horne, Malcolm K" uniqKey="Horne M" first="Malcolm K." last="Horne">Malcolm K. Horne</name><affiliation><mods:affiliation>Clinical Neurophysiology, Alfred Hospital Prahran, Victoria, Australia 3181</mods:affiliation><wicri:noCountry code="subField">Australia 3181</wicri:noCountry></affiliation></author><author><name sortKey="Smith, Graeme C" sort="Smith, Graeme C" uniqKey="Smith G" first="Graeme C." last="Smith">Graeme C. Smith</name><affiliation><mods:affiliation>Monash University, Department of Psychological Medicine, Prince Henry's Hospital Melbourne, Victoria, Australia 3004</mods:affiliation><wicri:noCountry code="subField">Australia 3004</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research Bulletin</title><title level="j" type="abbrev">BRB</title><idno type="ISSN">0361-9230</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986">1986</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="57">57</biblScope><biblScope unit="page" to="61">61</biblScope></imprint><idno type="ISSN">0361-9230</idno></series><idno type="istex">1825126A88D3DC9E27A819C005A1542CAA55C6BC</idno><idno type="DOI">10.1016/0361-9230(87)90165-1</idno><idno type="PII">0361-9230(87)90165-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0361-9230</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The selective neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was injected (IV) into monkeys (Macaca fasicularis) in two different injection regimes. With the small dose regime, one monkey was injected with 0.25 mg/kg, every other day, over a 16 day period. In the large dose regime, another monkey was injected with 0.5 mg/kg every other day, over an 8 day period. While the time required for drug delivery was varied between animals, the total dose delivered was 2 mg/kg in both animals. Before, during and for 14 days after the course of drug administration both animals were assessed on several motor function tests. The animal receiving the small dose regime showed normal motor performance on all tests for the duration of the study, however, the monkey receiving the large dose regime displayed progressive akinesia, muscular rigidity and aphagia. In fact, impairment was so severe that this animal had to be force fed and maintained with daily oral L-dopa. Fluorescent histochemical assessment of forebrain in both monkeys revealed that striatal tissue was totally devoid of fluorescence in both cases. Large, swollen axons in the internal capsule, hypothalamus and midbrain were visible only in the severely impaired animal. These results suggest that, as with other neurotoxins, degeneration associated increases in amines may be important in the aetiology of Parkinson-like motor impairment produced by selective neurotoxins.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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