Brain diffusion‐weighted imaging in Friedreich's ataxia
Identifieur interne : 002774 ( Main/Curation ); précédent : 002773; suivant : 002775Brain diffusion‐weighted imaging in Friedreich's ataxia
Auteurs : Giovanni Rizzo [Italie] ; Caterina Tonon [Italie] ; Maria Lucia Valentino [Italie] ; David Manners [Italie] ; Filippo Fortuna [Italie] ; Cinzia Gellera [Italie] ; Antonella Pini [Italie] ; Alessandro Ghezzo [Italie] ; Agostino Baruzzi [Italie] ; Claudia Testa [Italie] ; Emil Malucelli [Italie] ; Bruno Barbiroli [Italie] ; Valerio Carelli [Italie] ; Raffaele Lodi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
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Abstract
Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23518
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Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Pini, Antonella" sort="Pini, Antonella" uniqKey="Pini A" first="Antonella" last="Pini">Antonella Pini</name><affiliation wicri:level="1"><mods:affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuropsichiatric Unit, Ospedale Maggiore, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Ghezzo, Alessandro" sort="Ghezzo, Alessandro" uniqKey="Ghezzo A" first="Alessandro" last="Ghezzo">Alessandro Ghezzo</name><affiliation wicri:level="1"><mods:affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuropsichiatric Unit, Ospedale Maggiore, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23518</idno><idno type="url">https://api.istex.fr/document/74A749AB62758B4B7AE369D7165AFEBB9A1B7E12/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002B39</idno><idno type="wicri:Area/Main/Curation">002774</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brain diffusion‐weighted imaging in Friedreich's ataxia</title><author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Valentino, Maria Lucia" sort="Valentino, Maria Lucia" uniqKey="Valentino M" first="Maria Lucia" last="Valentino">Maria Lucia Valentino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Fortuna, Filippo" sort="Fortuna, Filippo" uniqKey="Fortuna F" first="Filippo" last="Fortuna">Filippo Fortuna</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><affiliation wicri:level="1"><mods:affiliation>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Pini, Antonella" sort="Pini, Antonella" uniqKey="Pini A" first="Antonella" last="Pini">Antonella Pini</name><affiliation wicri:level="1"><mods:affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuropsichiatric Unit, Ospedale Maggiore, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Ghezzo, Alessandro" sort="Ghezzo, Alessandro" uniqKey="Ghezzo A" first="Alessandro" last="Ghezzo">Alessandro Ghezzo</name><affiliation wicri:level="1"><mods:affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuropsichiatric Unit, Ospedale Maggiore, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><affiliation wicri:level="1"><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="705">705</biblScope><biblScope unit="page" to="712">712</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</idno><idno type="DOI">10.1002/mds.23518</idno><idno type="ArticleID">MDS23518</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Friedreich's ataxia</term><term>MRI</term><term>diffusion‐weighted imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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