Brain diffusion‐weighted imaging in Friedreich's ataxia
Identifieur interne : 002B39 ( Main/Corpus ); précédent : 002B38; suivant : 002B40Brain diffusion‐weighted imaging in Friedreich's ataxia
Auteurs : Giovanni Rizzo ; Caterina Tonon ; Maria Lucia Valentino ; David Manners ; Filippo Fortuna ; Cinzia Gellera ; Antonella Pini ; Alessandro Ghezzo ; Agostino Baruzzi ; Claudia Testa ; Emil Malucelli ; Bruno Barbiroli ; Valerio Carelli ; Raffaele LodiSource :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
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Abstract
Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23518
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain diffusion‐weighted imaging in Friedreich's ataxia</title><author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Valentino, Maria Lucia" sort="Valentino, Maria Lucia" uniqKey="Valentino M" first="Maria Lucia" last="Valentino">Maria Lucia Valentino</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Fortuna, Filippo" sort="Fortuna, Filippo" uniqKey="Fortuna F" first="Filippo" last="Fortuna">Filippo Fortuna</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><affiliation><mods:affiliation>U.O. 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Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23518</idno><idno type="url">https://api.istex.fr/document/74A749AB62758B4B7AE369D7165AFEBB9A1B7E12/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002B39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brain diffusion‐weighted imaging in Friedreich's ataxia</title><author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Valentino, Maria Lucia" sort="Valentino, Maria Lucia" uniqKey="Valentino M" first="Maria Lucia" last="Valentino">Maria Lucia Valentino</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Fortuna, Filippo" sort="Fortuna, Filippo" uniqKey="Fortuna F" first="Filippo" last="Fortuna">Filippo Fortuna</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><affiliation><mods:affiliation>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pini, Antonella" sort="Pini, Antonella" uniqKey="Pini A" first="Antonella" last="Pini">Antonella Pini</name><affiliation><mods:affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ghezzo, Alessandro" sort="Ghezzo, Alessandro" uniqKey="Ghezzo A" first="Alessandro" last="Ghezzo">Alessandro Ghezzo</name><affiliation><mods:affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><affiliation><mods:affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="705">705</biblScope><biblScope unit="page" to="712">712</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</idno><idno type="DOI">10.1002/mds.23518</idno><idno type="ArticleID">MDS23518</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Friedreich's ataxia</term><term>MRI</term><term>diffusion‐weighted imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Giovanni Rizzo MD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string><json:string>Department of Neurological Sciences, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Caterina Tonon MD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Maria Lucia Valentino MD</name><affiliations><json:string>Department of Neurological Sciences, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>David Manners DPhil</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Filippo Fortuna MD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string><json:string>Department of Neurological Sciences, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Cinzia Gellera MD</name><affiliations><json:string>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano, Italy</json:string></affiliations></json:item><json:item><name>Antonella Pini MD</name><affiliations><json:string>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Alessandro Ghezzo MD</name><affiliations><json:string>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Agostino Baruzzi MD</name><affiliations><json:string>Department of Neurological Sciences, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Claudia Testa PhD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Emil Malucelli PhD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Bruno Barbiroli MD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Valerio Carelli MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Raffaele Lodi MD</name><affiliations><json:string>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Friedreich's ataxia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diffusion‐weighted imaging</value></json:item></subject><articleId><json:string>MDS23518</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P > 0.001), ICP (P > 0.001), MCP (P > 0.01), SCP (P > 0.001), OR (P > 0.001), and at the level of the infratentorial structures such as brainstem (P > 0.01), cerebellar hemispheres (P > 0.01), and especially in the cerebellar vermis (P > 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.381</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1637</abstractCharCount><pdfWordCount>4417</pdfWordCount><pdfCharCount>29437</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>247</abstractWordCount></qualityIndicators><title>Brain diffusion‐weighted imaging in Friedreich's ataxia</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>712</last><first>705</first></pages><issn><json:string>0885-3185</json:string></issn><issue>4</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23518</json:string></doi><id>74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/74A749AB62758B4B7AE369D7165AFEBB9A1B7E12/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/74A749AB62758B4B7AE369D7165AFEBB9A1B7E12/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/74A749AB62758B4B7AE369D7165AFEBB9A1B7E12/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Brain diffusion‐weighted imaging in Friedreich's ataxia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note>Author Roles and Disclosures</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Brain diffusion‐weighted imaging in Friedreich's ataxia</title><author><persName><forename type="first">Giovanni</forename><surname>Rizzo</surname></persName><roleName type="degree">MD</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Caterina</forename><surname>Tonon</surname></persName><roleName type="degree">MD</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Maria Lucia</forename><surname>Valentino</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">David</forename><surname>Manners</surname></persName><roleName type="degree">DPhil</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Filippo</forename><surname>Fortuna</surname></persName><roleName type="degree">MD</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Cinzia</forename><surname>Gellera</surname></persName><roleName type="degree">MD</roleName><affiliation>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano, Italy</affiliation></author><author><persName><forename type="first">Antonella</forename><surname>Pini</surname></persName><roleName type="degree">MD</roleName><affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</affiliation></author><author><persName><forename type="first">Alessandro</forename><surname>Ghezzo</surname></persName><roleName type="degree">MD</roleName><affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</affiliation></author><author><persName><forename type="first">Agostino</forename><surname>Baruzzi</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Claudia</forename><surname>Testa</surname></persName><roleName type="degree">PhD</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Emil</forename><surname>Malucelli</surname></persName><roleName type="degree">PhD</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Bruno</forename><surname>Barbiroli</surname></persName><roleName type="degree">MD</roleName><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Valerio</forename><surname>Carelli</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Raffaele</forename><surname>Lodi</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy</p></note><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="705">705</biblScope><biblScope unit="page" to="712">712</biblScope></imprint></monogr><idno type="istex">74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</idno><idno type="DOI">10.1002/mds.23518</idno><idno type="ArticleID">MDS23518</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Friedreich's ataxia</term></item><item><term>MRI</term></item><item><term>diffusion‐weighted imaging</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-06-21">Received</change><change when="2010-10-18">Registration</change><change when="2011-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/74A749AB62758B4B7AE369D7165AFEBB9A1B7E12/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley" registered="yes">10.1002/mds.v26.4</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2011-03">March 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="230" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23518</doi><idGroup><id type="unit" value="MDS23518"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-06-21"></event><event type="manuscriptRevised" date="2010-09-22"></event><event type="manuscriptAccepted" date="2010-10-18"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText" date="2011-07-19"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-03-02"></event><event type="publishedOnlineFinalForm" date="2011-04-19"></event><event type="firstOnline" date="2011-03-02"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">705</numbering><numbering type="pageLast">712</numbering></numberingGroup><correspondenceTo>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23518.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="7096"></count></countGroup><titleGroup><title type="main" xml:lang="en">Brain diffusion‐weighted imaging in Friedreich's ataxia<link href="#fn6"></link></title><title type="short" xml:lang="en">DWI in FRDA</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Giovanni</givenNames><familyName>Rizzo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Caterina</givenNames><familyName>Tonon</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Maria Lucia</givenNames><familyName>Valentino</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>David</givenNames><familyName>Manners</familyName><degrees>DPhil</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Filippo</givenNames><familyName>Fortuna</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Cinzia</givenNames><familyName>Gellera</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Antonella</givenNames><familyName>Pini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Alessandro</givenNames><familyName>Ghezzo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Agostino</givenNames><familyName>Baruzzi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claudia</givenNames><familyName>Testa</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Emil</givenNames><familyName>Malucelli</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Bruno</givenNames><familyName>Barbiroli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Valerio</givenNames><familyName>Carelli</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Raffaele</givenNames><familyName>Lodi</familyName><degrees>MD</degrees></personName><contactDetails><email>raffaele.lodi@unibo.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Friedreich's ataxia</keyword><keyword xml:id="kwd2">MRI</keyword><keyword xml:id="kwd3">diffusion‐weighted imaging</keyword></keywordGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23518:MDS_23518_sm_authorroles"></mediaResource><caption>Author Roles and Disclosures</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI).</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS).</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>FRDA patients had significantly higher MD values than controls in medulla (<i>P</i> < 0.001), ICP (<i>P</i> < 0.001), MCP (<i>P</i> < 0.01), SCP (<i>P</i> < 0.001), OR (<i>P</i> < 0.001), and at the level of the infratentorial structures such as brainstem (<i>P</i> < 0.01), cerebellar hemispheres (<i>P</i> < 0.01), and especially in the cerebellar vermis (<i>P</i> < 0.001). MD values were strongly correlated with disease duration and ICARS score.</p></section><section xml:id="abs1-4"><title type="main">Discussion:</title><p>Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in <i>FRDA</i>, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn6"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Brain diffusion‐weighted imaging in Friedreich's ataxia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DWI in FRDA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Brain diffusion‐weighted imaging in Friedreich's ataxia</title></titleInfo><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Rizzo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caterina</namePart><namePart type="family">Tonon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria Lucia</namePart><namePart type="family">Valentino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Manners</namePart><namePart type="termsOfAddress">DPhil</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Filippo</namePart><namePart type="family">Fortuna</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cinzia</namePart><namePart type="family">Gellera</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonella</namePart><namePart type="family">Pini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandro</namePart><namePart type="family">Ghezzo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuropsichiatric Unit, Ospedale Maggiore, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Agostino</namePart><namePart type="family">Baruzzi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudia</namePart><namePart type="family">Testa</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emil</namePart><namePart type="family">Malucelli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Barbiroli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valerio</namePart><namePart type="family">Carelli</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raffaele</namePart><namePart type="family">Lodi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy</affiliation><description>Correspondence: MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-03</dateIssued><dateCaptured encoding="w3cdtf">2010-06-21</dateCaptured><dateValid encoding="w3cdtf">2010-10-18</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent><extent unit="references">35</extent><extent unit="words">7096</extent></physicalDescription><abstract lang="en">Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</abstract><note type="additional physical form">Author Roles and Disclosures</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Friedreich's ataxia</topic><topic>MRI</topic><topic>diffusion‐weighted imaging</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>705</start><end>712</end><total>8</total></extent></part></relatedItem><identifier type="istex">74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</identifier><identifier type="DOI">10.1002/mds.23518</identifier><identifier type="ArticleID">MDS23518</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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