S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Identifieur interne : 002417 ( Main/Curation ); précédent : 002416; suivant : 002418S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Auteurs : Alexis Elbaz [France] ; Clotilde Levecque [France] ; Jacqueline Clavel [France] ; Jean-Sébastien Vidal [France] ; Florence Richard [France] ; Jean-René Corrèze [France] ; Bernard Delemotte [France] ; Philippe Amouyel [France] ; Annick Alpérovitch [France] ; Marie-Christine Chartier-Harlin [France] ; Christophe Tzourio [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-02.
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Abstract
We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10326
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Hôpital Saint‐Antoine, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Correze, Jean Ene" sort="Correze, Jean Ene" uniqKey="Correze J" first="Jean-René" last="Corrèze">Jean-René Corrèze</name><affiliation wicri:level="1"><mods:affiliation>Mutualité Sociale Agricole, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Mutualité Sociale Agricole, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Delemotte, Bernard" sort="Delemotte, Bernard" uniqKey="Delemotte B" first="Bernard" last="Delemotte">Bernard Delemotte</name><affiliation wicri:level="1"><mods:affiliation>Mutualité Sociale Agricole, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Mutualité Sociale Agricole, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-02">2003-02</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="130">130</biblScope><biblScope unit="page" to="137">137</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BE94855532A1663DE19AF51C8B746A2135B06CD5</idno><idno type="DOI">10.1002/mds.10326</idno><idno type="ArticleID">MDS10326</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>UCH‐L1</term><term>age at onset</term><term>case‐control</term><term>interaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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