S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Identifieur interne : 002760 ( Main/Corpus ); précédent : 002759; suivant : 002761S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Auteurs : Alexis Elbaz ; Clotilde Levecque ; Jacqueline Clavel ; Jean-Sébastien Vidal ; Florence Richard ; Jean-René Corrèze ; Bernard Delemotte ; Philippe Amouyel ; Annick Alpérovitch ; Marie-Christine Chartier-Harlin ; Christophe TzourioSource :
- Movement Disorders [ 0885-3185 ] ; 2003-02.
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Abstract
We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10326
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sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alexis Elbaz MD, PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Clotilde Levecque MSc</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</json:string></affiliations></json:item><json:item><name>Jacqueline Clavel MD, PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 170, Villejuif, France</json:string></affiliations></json:item><json:item><name>Jean‐Sébastien Vidal MD</name><affiliations><json:string>Service de Neurologie, Hôpital Saint‐Antoine, Paris, France</json:string></affiliations></json:item><json:item><name>Florence Richard MD, PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</json:string></affiliations></json:item><json:item><name>Jean‐René Corrèze MD</name><affiliations><json:string>Mutualité Sociale Agricole, Paris, France</json:string></affiliations></json:item><json:item><name>Bernard Delemotte MD</name><affiliations><json:string>Mutualité Sociale Agricole, Paris, France</json:string></affiliations></json:item><json:item><name>Philippe Amouyel MD, PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</json:string></affiliations></json:item><json:item><name>Annick Alpérovitch MD, MSc</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Marie‐Christine Chartier‐Harlin PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Christophe Tzourio MD, PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>UCH‐L1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>case‐control</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>age at onset</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interaction</value></json:item></subject><articleId><json:string>MDS10326</json:string></articleId><language><json:string>eng</json:string></language><abstract>We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</abstract><qualityIndicators><score>7.664</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1394</abstractCharCount><pdfWordCount>4904</pdfWordCount><pdfCharCount>30292</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>230</abstractWordCount></qualityIndicators><title>S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship</title><genre><json:string>article</json:string></genre><host><volume>18</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>137</last><first>130</first></pages><issn><json:string>0885-3185</json:string></issn><issue>2</issue><subject><json:item><value>Research 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type="first">Alexis</forename><surname>Elbaz</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: INSERM Unit 360, Hôpital de la Salpêtrière, 47 blvd de l'Hôpital, 75651 Paris Cedex 13, France</p></note><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</affiliation></author><author><persName><forename type="first">Clotilde</forename><surname>Levecque</surname></persName><roleName type="degree">MSc</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</affiliation></author><author><persName><forename type="first">Jacqueline</forename><surname>Clavel</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 170, Villejuif, France</affiliation></author><author><persName><forename type="first">Jean‐Sébastien</forename><surname>Vidal</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Neurologie, Hôpital Saint‐Antoine, Paris, France</affiliation></author><author><persName><forename type="first">Florence</forename><surname>Richard</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</affiliation></author><author><persName><forename type="first">Jean‐René</forename><surname>Corrèze</surname></persName><roleName type="degree">MD</roleName><affiliation>Mutualité Sociale Agricole, Paris, France</affiliation></author><author><persName><forename type="first">Bernard</forename><surname>Delemotte</surname></persName><roleName type="degree">MD</roleName><affiliation>Mutualité Sociale Agricole, Paris, France</affiliation></author><author><persName><forename type="first">Philippe</forename><surname>Amouyel</surname></persName><roleName 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France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-02"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="130">130</biblScope><biblScope unit="page" to="137">137</biblScope></imprint></monogr><idno type="istex">BE94855532A1663DE19AF51C8B746A2135B06CD5</idno><idno type="DOI">10.1002/mds.10326</idno><idno type="ArticleID">MDS10326</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>UCH‐L1</term></item><item><term>case‐control</term></item><item><term>age at onset</term></item><item><term>interaction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-05-09">Received</change><change when="2002-08-05">Registration</change><change when="2003-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/BE94855532A1663DE19AF51C8B746A2135B06CD5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/mds.v18:2</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2003-02">February 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="20" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.10326</doi><idGroup><id type="unit" value="MDS10326"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2003 Movement Disorders Society</copyright><eventGroup><event type="manuscriptReceived" date="2002-05-09"></event><event type="manuscriptRevised" date="2002-07-17"></event><event type="manuscriptAccepted" date="2002-08-05"></event><event type="publishedOnlineEarlyUnpaginated" date="2002-10-28"></event><event type="firstOnline" date="2002-10-28"></event><event type="publishedOnlineFinalForm" date="2003-01-17"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">130</numbering><numbering type="pageLast">137</numbering></numberingGroup><correspondenceTo>INSERM Unit 360, Hôpital de la Salpêtrière, 47 blvd de l'Hôpital, 75651 Paris Cedex 13, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS10326.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="33"></count><count type="wordTotal" number="5604"></count></countGroup><titleGroup><title type="main" xml:lang="en">S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship</title><title type="short" xml:lang="en">UCH‐L1 and Age at Onset in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Alexis</givenNames><familyName>Elbaz</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>alexis.elbaz@chups.jussieu.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Clotilde</givenNames><familyName>Levecque</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jacqueline</givenNames><familyName>Clavel</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Jean‐Sébastien</givenNames><familyName>Vidal</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Florence</givenNames><familyName>Richard</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Jean‐René</givenNames><familyName>Corrèze</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Bernard</givenNames><familyName>Delemotte</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Philippe</givenNames><familyName>Amouyel</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Annick</givenNames><familyName>Alpérovitch</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Marie‐Christine</givenNames><familyName>Chartier‐Harlin</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Christophe</givenNames><familyName>Tzourio</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Institut National de la Santé et de la Recherche Médicale, Unit 170, Villejuif, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Service de Neurologie, Hôpital Saint‐Antoine, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Mutualité Sociale Agricole, Paris, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">UCH‐L1</keyword><keyword xml:id="kwd3">case‐control</keyword><keyword xml:id="kwd4">age at onset</keyword><keyword xml:id="kwd5">interaction</keyword></keywordGroup><fundingInfo><fundingAgency>INSERM, Institut Pasteur de Lille</fundingAgency></fundingInfo><fundingInfo><fundingAgency>MSA</fundingAgency></fundingInfo><fundingInfo><fundingAgency>French Ministry of the Environment</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ministère de la Recherche et de la Technologie</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (<i>P</i> = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (<i>P</i> = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>UCH‐L1 and Age at Onset in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship</title></titleInfo><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Elbaz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</affiliation><description>Correspondence: INSERM Unit 360, Hôpital de la Salpêtrière, 47 blvd de l'Hôpital, 75651 Paris Cedex 13, France</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clotilde</namePart><namePart type="family">Levecque</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacqueline</namePart><namePart type="family">Clavel</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 170, Villejuif, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Sébastien</namePart><namePart type="family">Vidal</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, Hôpital Saint‐Antoine, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Florence</namePart><namePart type="family">Richard</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐René</namePart><namePart type="family">Corrèze</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Mutualité Sociale Agricole, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernard</namePart><namePart type="family">Delemotte</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Mutualité Sociale Agricole, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Amouyel</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 508, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annick</namePart><namePart type="family">Alpérovitch</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Christine</namePart><namePart type="family">Chartier‐Harlin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christophe</namePart><namePart type="family">Tzourio</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 360, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2003-02</dateIssued><dateCaptured encoding="w3cdtf">2002-05-09</dateCaptured><dateValid encoding="w3cdtf">2002-08-05</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">33</extent><extent unit="words">5604</extent></physicalDescription><abstract lang="en">We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</abstract><note type="funding">INSERM, Institut Pasteur de Lille</note><note type="funding">MSA</note><note type="funding">French Ministry of the Environment</note><note type="funding">Ministère de la Recherche et de la Technologie</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>UCH‐L1</topic><topic>case‐control</topic><topic>age at onset</topic><topic>interaction</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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