Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease
Identifieur interne : 001F65 ( Main/Curation ); précédent : 001F64; suivant : 001F66Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease
Auteurs : Elena Moro [Canada] ; Andres M. Lozano [Canada] ; Pierre Pollak [France] ; Yves Agid [France] ; Stig Rehncrona [Suède] ; Jens Volkmann [Allemagne] ; Jaime Kulisevsky [Espagne] ; Jose A. Obeso [Espagne] ; Alberto Albanese [Italie] ; Marwan I. Hariz [Royaume-Uni, Suède] ; Niall P. Quinn [Royaume-Uni] ; Jans D. Speelman [Pays-Bas] ; Alim L. Benabid [France] ; Valerie Fraix [France] ; Alexandre Mendes [France] ; Marie-Laure Welter [France] ; Jean-Luc Houeto [France] ; Philippe Cornu [France] ; Didier Dormont [France] ; Annalena L. Tornqvist [Suède] ; Ron Ekberg [Suède] ; Alfons Schnitzler [Allemagne] ; Lars Timmermann [Allemagne] ; Lars Wojtecki [Allemagne] ; Andres Gironell [Espagne] ; Maria C. Rodriguez-Oroz [Espagne] ; Jorge Guridi [Espagne] ; Anna R. Bentivoglio [Italie] ; Maria F. Contarino [Italie, Pays-Bas] ; Luigi Romito [Italie] ; Massimo Scerrati [Italie] ; Marc Janssens [Pays-Bas] ; Anthony E. Lang [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
English descriptors
Abstract
We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22735
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Quinn</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academic Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name><affiliation wicri:level="1"><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Neurosurgery Service, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><affiliation wicri:level="1"><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Neurosurgery Service, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital, Cologne, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation></author><author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academic Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona</wicri:regionArea></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Bakken Research Center, Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.22735</idno><idno type="url">https://api.istex.fr/document/A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002280</idno><idno type="wicri:Area/Main/Curation">001F65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="1"><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><mods:affiliation>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Neurosurgery Service, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><mods:affiliation>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academic Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name><affiliation wicri:level="1"><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Neurosurgery Service, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><affiliation wicri:level="1"><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Neurosurgery Service, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital, Cologne, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation></author><author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academic Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona</wicri:regionArea></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Bakken Research Center, Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="578">578</biblScope><biblScope unit="page" to="586">586</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</idno><idno type="DOI">10.1002/mds.22735</idno><idno type="ArticleID">MDS22735</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>globus pallidus internus</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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