Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease
Identifieur interne : 002280 ( Main/Corpus ); précédent : 002279; suivant : 002281Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease
Auteurs : Elena Moro ; Andres M. Lozano ; Pierre Pollak ; Yves Agid ; Stig Rehncrona ; Jens Volkmann ; Jaime Kulisevsky ; Jose A. Obeso ; Alberto Albanese ; Marwan I. Hariz ; Niall P. Quinn ; Jans D. Speelman ; Alim L. Benabid ; Valerie Fraix ; Alexandre Mendes ; Marie-Laure Welter ; Jean-Luc Houeto ; Philippe Cornu ; Didier Dormont ; Annalena L. Tornqvist ; Ron Ekberg ; Alfons Schnitzler ; Lars Timmermann ; Lars Wojtecki ; Andres Gironell ; Maria C. Rodriguez-Oroz ; Jorge Guridi ; Anna R. Bentivoglio ; Maria F. Contarino ; Luigi Romito ; Massimo Scerrati ; Marc Janssens ; Anthony E. LangSource :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
English descriptors
Abstract
We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22735
Links to Exploration step
ISTEX:A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><mods:affiliation>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation><mods:affiliation>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><affiliation><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name><affiliation><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</mods:affiliation></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name><affiliation><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><affiliation><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital, Cologne, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><affiliation><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</mods:affiliation></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.22735</idno><idno type="url">https://api.istex.fr/document/A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><mods:affiliation>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation><mods:affiliation>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><affiliation><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation><mods:affiliation>Institute of Neurology, Queen Square, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name><affiliation><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation><mods:affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</mods:affiliation></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation><mods:affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name><affiliation><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><affiliation><mods:affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital, Cologne, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation><mods:affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><affiliation><mods:affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</mods:affiliation></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="578">578</biblScope><biblScope unit="page" to="586">586</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</idno><idno type="DOI">10.1002/mds.22735</idno><idno type="ArticleID">MDS22735</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>globus pallidus internus</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elena Moro MD, PhD</name><affiliations><json:string>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Andres M. Lozano MD, PhD</name><affiliations><json:string>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Pierre Pollak MD</name><affiliations><json:string>Service de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Yves Agid MD</name><affiliations><json:string>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</json:string></affiliations></json:item><json:item><name>Stig Rehncrona MD</name><affiliations><json:string>Neurosurgery Service, Lund University Hospital, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Jens Volkmann MD, PhD</name><affiliations><json:string>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Jaime Kulisevsky MD</name><affiliations><json:string>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Jose A. Obeso MD</name><affiliations><json:string>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</json:string></affiliations></json:item><json:item><name>Alberto Albanese MD, PhD</name><affiliations><json:string>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</json:string><json:string>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</json:string></affiliations></json:item><json:item><name>Marwan I. Hariz MD</name><affiliations><json:string>Institute of Neurology, Queen Square, London, UK</json:string><json:string>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</json:string></affiliations></json:item><json:item><name>Niall P. Quinn MD</name><affiliations><json:string>Institute of Neurology, Queen Square, London, UK</json:string></affiliations></json:item><json:item><name>Jans D. Speelman MD</name><affiliations><json:string>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Alim L. Benabid MD, PhD</name><affiliations><json:string>Service de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Valerie Fraix MD</name><affiliations><json:string>Service de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Alexandre Mendes MD</name><affiliations><json:string>Service de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Marie‐Laure Welter MD</name><affiliations><json:string>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</json:string></affiliations></json:item><json:item><name>Jean‐Luc Houeto MD</name><affiliations><json:string>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</json:string><json:string>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</json:string></affiliations></json:item><json:item><name>Philippe Cornu MD</name><affiliations><json:string>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</json:string></affiliations></json:item><json:item><name>Didier Dormont MD</name><affiliations><json:string>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</json:string></affiliations></json:item><json:item><name>Annalena L. Tornqvist RN</name><affiliations><json:string>Neurosurgery Service, Lund University Hospital, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Ron Ekberg MD</name><affiliations><json:string>Neurosurgery Service, Lund University Hospital, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Alfons Schnitzler MD</name><affiliations><json:string>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</json:string></affiliations></json:item><json:item><name>Lars Timmermann MD</name><affiliations><json:string>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</json:string><json:string>Department of Neurology, University Hospital, Cologne, Germany</json:string></affiliations></json:item><json:item><name>Lars Wojtecki MD</name><affiliations><json:string>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</json:string></affiliations></json:item><json:item><name>Andres Gironell MD</name><affiliations><json:string>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Maria C. Rodriguez‐Oroz MD, PhD</name><affiliations><json:string>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</json:string></affiliations></json:item><json:item><name>Jorge Guridi MD</name><affiliations><json:string>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</json:string></affiliations></json:item><json:item><name>Anna R. Bentivoglio MD, PhD</name><affiliations><json:string>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</json:string></affiliations></json:item><json:item><name>Maria F. Contarino MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</json:string><json:string>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Luigi Romito MD</name><affiliations><json:string>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</json:string></affiliations></json:item><json:item><name>Massimo Scerrati MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</json:string><json:string>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</json:string></affiliations></json:item><json:item><name>Marc Janssens PhD</name><affiliations><json:string>Bakken Research Center, Maastricht, The Netherlands</json:string></affiliations></json:item><json:item><name>Anthony E. Lang MD</name><affiliations><json:string>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>globus pallidus internus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item></subject><articleId><json:string>MDS22735</json:string></articleId><language><json:string>eng</json:string></language><abstract>We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P > 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P > 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.988</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1639</abstractCharCount><pdfWordCount>5260</pdfWordCount><pdfCharCount>33125</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>249</abstractWordCount></qualityIndicators><title>Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>9</total><last>586</last><first>578</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22735</json:string></doi><id>A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title><author><persName><forename type="first">Elena</forename><surname>Moro</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Toronto Western Hospital, Movement Disorders Center, 399 Bathurst Street McL7‐402, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8 Canada</p></note><affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Andres M.</forename><surname>Lozano</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Yves</forename><surname>Agid</surname></persName><roleName type="degree">MD</roleName><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation></author><author><persName><forename type="first">Stig</forename><surname>Rehncrona</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</affiliation></author><author><persName><forename type="first">Jens</forename><surname>Volkmann</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</affiliation></author><author><persName><forename type="first">Jaime</forename><surname>Kulisevsky</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Jose A.</forename><surname>Obeso</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</affiliation></author><author><persName><forename type="first">Alberto</forename><surname>Albanese</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</affiliation><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation></author><author><persName><forename type="first">Marwan I.</forename><surname>Hariz</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurology, Queen Square, London, UK</affiliation><affiliation>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</affiliation></author><author><persName><forename type="first">Niall P.</forename><surname>Quinn</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurology, Queen Square, London, UK</affiliation></author><author><persName><forename type="first">Jans D.</forename><surname>Speelman</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Alim L.</forename><surname>Benabid</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Valerie</forename><surname>Fraix</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Alexandre</forename><surname>Mendes</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Marie‐Laure</forename><surname>Welter</surname></persName><roleName type="degree">MD</roleName><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation></author><author><persName><forename type="first">Jean‐Luc</forename><surname>Houeto</surname></persName><roleName type="degree">MD</roleName><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation><affiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</affiliation></author><author><persName><forename type="first">Philippe</forename><surname>Cornu</surname></persName><roleName type="degree">MD</roleName><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation></author><author><persName><forename type="first">Didier</forename><surname>Dormont</surname></persName><roleName type="degree">MD</roleName><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation></author><author><persName><forename type="first">Annalena L.</forename><surname>Tornqvist</surname></persName><roleName type="degree">RN</roleName><affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</affiliation></author><author><persName><forename type="first">Ron</forename><surname>Ekberg</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</affiliation></author><author><persName><forename type="first">Alfons</forename><surname>Schnitzler</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</affiliation></author><author><persName><forename type="first">Lars</forename><surname>Timmermann</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</affiliation><affiliation>Department of Neurology, University Hospital, Cologne, Germany</affiliation></author><author><persName><forename type="first">Lars</forename><surname>Wojtecki</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</affiliation></author><author><persName><forename type="first">Andres</forename><surname>Gironell</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Maria C.</forename><surname>Rodriguez‐Oroz</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</affiliation></author><author><persName><forename type="first">Jorge</forename><surname>Guridi</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</affiliation></author><author><persName><forename type="first">Anna R.</forename><surname>Bentivoglio</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation></author><author><persName><forename type="first">Maria F.</forename><surname>Contarino</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation><affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Luigi</forename><surname>Romito</surname></persName><roleName type="degree">MD</roleName><affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</affiliation></author><author><persName><forename type="first">Massimo</forename><surname>Scerrati</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation><affiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</affiliation></author><author><persName><forename type="first">Marc</forename><surname>Janssens</surname></persName><roleName type="degree">PhD</roleName><affiliation>Bakken Research Center, Maastricht, The Netherlands</affiliation></author><author><persName><forename type="first">Anthony E.</forename><surname>Lang</surname></persName><roleName type="degree">MD</roleName><affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="578">578</biblScope><biblScope unit="page" to="586">586</biblScope></imprint></monogr><idno type="istex">A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</idno><idno type="DOI">10.1002/mds.22735</idno><idno type="ArticleID">MDS22735</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>deep brain stimulation</term></item><item><term>globus pallidus internus</term></item><item><term>Parkinson's disease</term></item><item><term>subthalamic nucleus</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-12-14">Received</change><change when="2009-07-08">Registration</change><change when="2010-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mds.v25:5</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2010-04-15">15 April 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="90" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22735</doi><idGroup><id type="unit" value="MDS22735"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-12-14"></event><event type="manuscriptRevised" date="2009-04-13"></event><event type="manuscriptAccepted" date="2009-07-08"></event><event type="firstOnline" date="2010-03-08"></event><event type="publishedOnlineFinalForm" date="2010-04-21"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-03-08"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText" date="2011-08-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">578</numbering><numbering type="pageLast">586</numbering></numberingGroup><correspondenceTo>Toronto Western Hospital, Movement Disorders Center, 399 Bathurst Street McL7‐402, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8 Canada</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22735.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="7247"></count></countGroup><titleGroup><title type="main" xml:lang="en">Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Study on Subthalamic and Pallidal Stimulation</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Elena</givenNames><familyName>Moro</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>elena.moro@uhn.on.ca</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Andres M.</givenNames><familyName>Lozano</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Pierre</givenNames><familyName>Pollak</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Yves</givenNames><familyName>Agid</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Stig</givenNames><familyName>Rehncrona</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Jens</givenNames><familyName>Volkmann</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Jaime</givenNames><familyName>Kulisevsky</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Jose A.</givenNames><familyName>Obeso</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af9 #af10"><personName><givenNames>Alberto</givenNames><familyName>Albanese</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af11 #af12"><personName><givenNames>Marwan I.</givenNames><familyName>Hariz</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Niall P.</givenNames><familyName>Quinn</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af13"><personName><givenNames>Jans D.</givenNames><familyName>Speelman</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Alim L.</givenNames><familyName>Benabid</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Valerie</givenNames><familyName>Fraix</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Alexandre</givenNames><familyName>Mendes</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Marie‐Laure</givenNames><familyName>Welter</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af4 #af14"><personName><givenNames>Jean‐Luc</givenNames><familyName>Houeto</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Philippe</givenNames><familyName>Cornu</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au19" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Didier</givenNames><familyName>Dormont</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au20" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Annalena L.</givenNames><familyName>Tornqvist</familyName><degrees>RN</degrees></personName></creator><creator xml:id="au21" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Ron</givenNames><familyName>Ekberg</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au22" creatorRole="author" affiliationRef="#af15"><personName><givenNames>Alfons</givenNames><familyName>Schnitzler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au23" creatorRole="author" affiliationRef="#af15 #af16"><personName><givenNames>Lars</givenNames><familyName>Timmermann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au24" creatorRole="author" affiliationRef="#af15"><personName><givenNames>Lars</givenNames><familyName>Wojtecki</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au25" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Andres</givenNames><familyName>Gironell</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au26" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Maria C.</givenNames><familyName>Rodriguez‐Oroz</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au27" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Jorge</givenNames><familyName>Guridi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au28" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Anna R.</givenNames><familyName>Bentivoglio</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au29" creatorRole="author" affiliationRef="#af10 #af13"><personName><givenNames>Maria F.</givenNames><familyName>Contarino</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au30" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Luigi</givenNames><familyName>Romito</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au31" creatorRole="author" affiliationRef="#af10 #af17"><personName><givenNames>Massimo</givenNames><familyName>Scerrati</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au32" creatorRole="author" affiliationRef="#af18"><personName><givenNames>Marc</givenNames><familyName>Janssens</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au33" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Anthony E.</givenNames><familyName>Lang</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="SE" type="organization"><unparsedAffiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="DE" type="organization"><unparsedAffiliation>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="ES" type="organization"><unparsedAffiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="ES" type="organization"><unparsedAffiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="IT" type="organization"><unparsedAffiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="GB" type="organization"><unparsedAffiliation>Institute of Neurology, Queen Square, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="af12" countryCode="SE" type="organization"><unparsedAffiliation>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="FR" type="organization"><unparsedAffiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af16" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University Hospital, Cologne, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af17" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af18" countryCode="NL" type="organization"><unparsedAffiliation>Bakken Research Center, Maastricht, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">deep brain stimulation</keyword><keyword xml:id="kwd2">globus pallidus internus</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">subthalamic nucleus</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22735:MDS_22735_sm_supptables"></mediaResource><caption>Supproting Information.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, <i>P</i> < 0.0001, 45.4%; GPi, <i>P</i> = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, <i>P</i> < 0.001, 50.5%; GPi, <i>P</i> = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Study on Subthalamic and Pallidal Stimulation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Moro</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</affiliation><description>Correspondence: Toronto Western Hospital, Movement Disorders Center, 399 Bathurst Street McL7‐402, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8 Canada</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres M.</namePart><namePart type="family">Lozano</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Pollak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Agid</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stig</namePart><namePart type="family">Rehncrona</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Volkmann</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Neurologische Klinik der Christian‐Albrect‐Universitat, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaime</namePart><namePart type="family">Kulisevsky</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jose A.</namePart><namePart type="family">Obeso</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Albanese</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</affiliation><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marwan I.</namePart><namePart type="family">Hariz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, Queen Square, London, UK</affiliation><affiliation>Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Niall P.</namePart><namePart type="family">Quinn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, Queen Square, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jans D.</namePart><namePart type="family">Speelman</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alim L.</namePart><namePart type="family">Benabid</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valerie</namePart><namePart type="family">Fraix</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandre</namePart><namePart type="family">Mendes</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Laure</namePart><namePart type="family">Welter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Luc</namePart><namePart type="family">Houeto</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation><affiliation>Service de Neurologie, CHU de Poitiers, University of Poitiers, Poitiers, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Cornu</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Didier</namePart><namePart type="family">Dormont</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hôpital de la Salpêtrière, Fédération de Neurologie, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annalena L.</namePart><namePart type="family">Tornqvist</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ron</namePart><namePart type="family">Ekberg</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurosurgery Service, Lund University Hospital, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfons</namePart><namePart type="family">Schnitzler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Timmermann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</affiliation><affiliation>Department of Neurology, University Hospital, Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Wojtecki</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Institute of Clinical Neurosciences, Heinrich‐Heine‐Universitat Duesseldorf, Duesseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres</namePart><namePart type="family">Gironell</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria C.</namePart><namePart type="family">Rodriguez‐Oroz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jorge</namePart><namePart type="family">Guridi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED, Pamplona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna R.</namePart><namePart type="family">Bentivoglio</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria F.</namePart><namePart type="family">Contarino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation><affiliation>Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Romito</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto Nazionale Neurologico C. Besta and Università Cattolica, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Massimo</namePart><namePart type="family">Scerrati</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy</affiliation><affiliation>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Università Politecnica delle Marche, Ancona, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Janssens</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Bakken Research Center, Maastricht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony E.</namePart><namePart type="family">Lang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-04-15</dateIssued><dateCaptured encoding="w3cdtf">2008-12-14</dateCaptured><dateValid encoding="w3cdtf">2009-07-08</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">25</extent><extent unit="words">7247</extent></physicalDescription><abstract lang="en">We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>deep brain stimulation</topic><topic>globus pallidus internus</topic><topic>Parkinson's disease</topic><topic>subthalamic nucleus</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supproting Information. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>578</start><end>586</end><total>9</total></extent></part></relatedItem><identifier type="istex">A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060</identifier><identifier type="DOI">10.1002/mds.22735</identifier><identifier type="ArticleID">MDS22735</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002280 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002280 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:A4C92F8C738CD02AED63D0AA1C5D5B514C1B0060
|texte= Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |