Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study
Identifieur interne : 001D54 ( Main/Curation ); précédent : 001D53; suivant : 001D55Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study
Auteurs : Maria Teresa Pellecchia [Italie] ; Paolo Barone [Italie] ; Caterina Vicidomini [Italie] ; Carmine Mollica [Italie] ; Elena Salvatore [Italie] ; Marta Ianniciello [Italie] ; Raffaele Liuzzi [Italie] ; Katia Longo [Italie] ; Marina Picillo [Italie] ; Giuseppe De Michele [Italie] ; Alessandro Filla [Italie] ; Arturo Brunetti [Italie] ; Marco Salvatore [Italie] ; Sabina Pappatà [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-06.
English descriptors
Abstract
Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P < .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23601
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last="Salvatore">Elena Salvatore</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Liuzzi, Raffaele" sort="Liuzzi, Raffaele" uniqKey="Liuzzi R" first="Raffaele" last="Liuzzi">Raffaele Liuzzi</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Brunetti, Arturo" sort="Brunetti, Arturo" uniqKey="Brunetti A" first="Arturo" last="Brunetti">Arturo Brunetti</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomorphological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomorphological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Naples</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1303">1303</biblScope><biblScope unit="page" to="1309">1309</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3B065761ABA23BB79384748608EDA59439CA8BD4</idno><idno type="DOI">10.1002/mds.23601</idno><idno type="ArticleID">MDS23601</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>diffusion‐weighted imaging</term><term>longitudinal study</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P < .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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