Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study
Identifieur interne : 002055 ( Main/Corpus ); précédent : 002054; suivant : 002056Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study
Auteurs : Maria Teresa Pellecchia ; Paolo Barone ; Caterina Vicidomini ; Carmine Mollica ; Elena Salvatore ; Marta Ianniciello ; Raffaele Liuzzi ; Katia Longo ; Marina Picillo ; Giuseppe De Michele ; Alessandro Filla ; Arturo Brunetti ; Marco Salvatore ; Sabina PappatàSource :
- Movement Disorders [ 0885-3185 ] ; 2011-06.
English descriptors
Abstract
Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P < .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23601
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title><author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Vicidomini, 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Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3B065761ABA23BB79384748608EDA59439CA8BD4</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23601</idno><idno type="url">https://api.istex.fr/document/3B065761ABA23BB79384748608EDA59439CA8BD4/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title><author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>IRCCS Fondazione SDN, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Liuzzi, Raffaele" sort="Liuzzi, Raffaele" uniqKey="Liuzzi R" first="Raffaele" last="Liuzzi">Raffaele Liuzzi</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Brunetti, Arturo" sort="Brunetti, Arturo" uniqKey="Brunetti A" first="Arturo" last="Brunetti">Arturo Brunetti</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name><affiliation><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1303">1303</biblScope><biblScope unit="page" to="1309">1309</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3B065761ABA23BB79384748608EDA59439CA8BD4</idno><idno type="DOI">10.1002/mds.23601</idno><idno type="ArticleID">MDS23601</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>diffusion‐weighted imaging</term><term>longitudinal study</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P < .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Maria Teresa Pellecchia MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string><json:string>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Caterina Vicidomini PhD</name><affiliations><json:string>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</json:string></affiliations></json:item><json:item><name>Carmine Mollica MD, PhD</name><affiliations><json:string>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</json:string><json:string>IRCCS Fondazione SDN, Naples, Italy</json:string></affiliations></json:item><json:item><name>Elena Salvatore MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Marta Ianniciello MD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Raffaele Liuzzi PhD</name><affiliations><json:string>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</json:string></affiliations></json:item><json:item><name>Katia Longo MD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string><json:string>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Marina Picillo MD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Giuseppe De Michele MD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Alessandro Filla MD</name><affiliations><json:string>Department of Neurological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Arturo Brunetti MD</name><affiliations><json:string>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</json:string><json:string>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Marco Salvatore MD</name><affiliations><json:string>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</json:string><json:string>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Sabina Pappatà MD</name><affiliations><json:string>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diffusion‐weighted imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>longitudinal study</value></json:item></subject><articleId><json:string>MDS23601</json:string></articleId><language><json:string>eng</json:string></language><abstract>Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P > .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.677</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1754</abstractCharCount><pdfWordCount>3677</pdfWordCount><pdfCharCount>23031</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>265</abstractWordCount></qualityIndicators><title>Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>1309</last><first>1303</first></pages><issn><json:string>0885-3185</json:string></issn><issue>7</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23601</json:string></doi><id>3B065761ABA23BB79384748608EDA59439CA8BD4</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3B065761ABA23BB79384748608EDA59439CA8BD4/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3B065761ABA23BB79384748608EDA59439CA8BD4/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3B065761ABA23BB79384748608EDA59439CA8BD4/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: This work was supported by grants from the Italian Ministry of University and Research (prot. 2004063899 to M.S. and G.D.M. and EC‐FP6‐project DiMI, LSHB‐CT‐2005‐512146). Professor Paolo Barone has received compensation for consulting services from Boehringer Ingelheim, Novartis, Schwarz Pharma/UCB, and Lundbeck and has received research support from Boehringer Ingelheim. All other authors have no financial disclosures. Full financial disclosures and author roles can be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title><author><persName><forename type="first">Maria Teresa</forename><surname>Pellecchia</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</affiliation></author><author><persName><forename type="first">Caterina</forename><surname>Vicidomini</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation></author><author><persName><forename type="first">Carmine</forename><surname>Mollica</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><affiliation>IRCCS Fondazione SDN, Naples, Italy</affiliation></author><author><persName><forename type="first">Elena</forename><surname>Salvatore</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Marta</forename><surname>Ianniciello</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Raffaele</forename><surname>Liuzzi</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation></author><author><persName><forename type="first">Katia</forename><surname>Longo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</affiliation></author><author><persName><forename type="first">Marina</forename><surname>Picillo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Giuseppe</forename><surname>De Michele</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Alessandro</forename><surname>Filla</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Arturo</forename><surname>Brunetti</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Marco</forename><surname>Salvatore</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</affiliation></author><author><persName><forename type="first">Sabina</forename><surname>Pappatà</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Institute of Biostructure and Bioimaging, CNR, Via Pansini 5, Edificio 10, 80131 Naples, Italy</p></note><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1303">1303</biblScope><biblScope unit="page" to="1309">1309</biblScope></imprint></monogr><idno type="istex">3B065761ABA23BB79384748608EDA59439CA8BD4</idno><idno type="DOI">10.1002/mds.23601</idno><idno type="ArticleID">MDS23601</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P < .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>multiple system atrophy</term></item><item><term>diffusion‐weighted imaging</term></item><item><term>longitudinal study</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-07-05">Received</change><change when="2010-11-29">Registration</change><change when="2011-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3B065761ABA23BB79384748608EDA59439CA8BD4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="28"></count><count type="wordTotal" number="4781"></count></countGroup><titleGroup><title type="main" xml:lang="en">Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study<link href="#fn3"></link></title><title type="short" xml:lang="en">Serial Diffusion‐Weighted Imaging in MSA</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Maria Teresa</givenNames><familyName>Pellecchia</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Caterina</givenNames><familyName>Vicidomini</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Carmine</givenNames><familyName>Mollica</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Elena</givenNames><familyName>Salvatore</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Marta</givenNames><familyName>Ianniciello</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Raffaele</givenNames><familyName>Liuzzi</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Katia</givenNames><familyName>Longo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Marina</givenNames><familyName>Picillo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Giuseppe</givenNames><familyName>De Michele</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alessandro</givenNames><familyName>Filla</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af3 #af5"><personName><givenNames>Arturo</givenNames><familyName>Brunetti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af3 #af5"><personName><givenNames>Marco</givenNames><familyName>Salvatore</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af3" corresponding="yes"><personName><givenNames>Sabina</givenNames><familyName>Pappatà</familyName><degrees>MD</degrees></personName><contactDetails><email>sabina.pappata@cnr.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>IRCCS Fondazione SDN, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">multiple system atrophy</keyword><keyword xml:id="kwd2">diffusion‐weighted imaging</keyword><keyword xml:id="kwd3">longitudinal study</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (<i>P</i> < .001), pons (<i>P</i> = .003), cerebellar white matter (<i>P</i> = .03), thalamus (<i>P</i> = .013), and frontal white matter (<i>P</i> = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (<i>P</i> = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p><b>Relevant conflicts of interest/financial disclosures:</b> This work was supported by grants from the Italian Ministry of University and Research (prot. 2004063899 to M.S. and G.D.M. and EC‐FP6‐project DiMI, LSHB‐CT‐2005‐512146). Professor Paolo Barone has received compensation for consulting services from Boehringer Ingelheim, Novartis, Schwarz Pharma/UCB, and Lundbeck and has received research support from Boehringer Ingelheim. All other authors have no financial disclosures. Full financial disclosures and author roles can be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Serial Diffusion‐Weighted Imaging in MSA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion‐weighted MR study</title></titleInfo><name type="personal"><namePart type="given">Maria Teresa</namePart><namePart type="family">Pellecchia</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caterina</namePart><namePart type="family">Vicidomini</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmine</namePart><namePart type="family">Mollica</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><affiliation>IRCCS Fondazione SDN, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Salvatore</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marta</namePart><namePart type="family">Ianniciello</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raffaele</namePart><namePart type="family">Liuzzi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katia</namePart><namePart type="family">Longo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><affiliation>Institute of Diagnosis and Care “Hermitage Capodimonte,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marina</namePart><namePart type="family">Picillo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">De Michele</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandro</namePart><namePart type="family">Filla</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arturo</namePart><namePart type="family">Brunetti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marco</namePart><namePart type="family">Salvatore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><affiliation>Department of Biomorphological Sciences, University “Federico II,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabina</namePart><namePart type="family">Pappatà</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Biostructure and Bioimaging, CNR, Naples, Italy</affiliation><description>Correspondence: Institute of Biostructure and Bioimaging, CNR, Via Pansini 5, Edificio 10, 80131 Naples, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-06</dateIssued><dateCaptured encoding="w3cdtf">2010-07-05</dateCaptured><dateValid encoding="w3cdtf">2010-11-29</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">28</extent><extent unit="words">4781</extent></physicalDescription><abstract lang="en">Diffusion‐weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion‐weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion‐weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow‐up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow‐up in the putamen (P < .001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow‐up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow‐up period. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: This work was supported by grants from the Italian Ministry of University and Research (prot. 2004063899 to M.S. and G.D.M. and EC‐FP6‐project DiMI, LSHB‐CT‐2005‐512146). Professor Paolo Barone has received compensation for consulting services from Boehringer Ingelheim, Novartis, Schwarz Pharma/UCB, and Lundbeck and has received research support from Boehringer Ingelheim. All other authors have no financial disclosures. Full financial disclosures and author roles can be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>multiple system atrophy</topic><topic>diffusion‐weighted imaging</topic><topic>longitudinal study</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1303</start><end>1309</end><total>7</total></extent></part></relatedItem><identifier type="istex">3B065761ABA23BB79384748608EDA59439CA8BD4</identifier><identifier type="DOI">10.1002/mds.23601</identifier><identifier type="ArticleID">MDS23601</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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