ParkinsonV1, Main, Curation, bibRecord, 001999

D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy

Identifieur interne : 001999 ( Main/Curation ); précédent : 001998; suivant : 001A00

D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy

Auteurs : Laurent Pierot [France] ; Claire Desnos [France] ; Jerome Blin [France] ; Rita Raisman [France] ; Daniel Scherman [France] ; France Javoy-Agid [France] ; Merle Ruberg [France] ; Yves Agid [France]

Source :

Journal of the Neurological Sciences [ 0022-510X ] ; 1988.

RBID : ISTEX:FB890763DD020CDFE4B4FC9F1CFEEE904A0C53E3

Abstract

The densities of D1- and D2-type dopamine receptors were measured with [3H]SCH23390 and [3H]spiperone, in the caudate nucleus and putamen of a large series of patients with Parkinson's disease or progressive supranuclear palsy, in relation to markers of dopaminergic and cholinergic innervation of the striatum ([3H]dihydrotetrabenazine binding and choline acetyltransferase activity). Correlations were sought between these parameters and clinical characteristics of the patients (abnormal involuntary movements, dementia, confusional syndrome or treatment).In Parkinson's disease, the densities of both types of receptors were unchanged, whereas in PSP, the density of D2, but not D1-type dopamine receptors, was decreased in the caudate nucleus and the putamen. No correlations between the biochemical and clinical data were found.

Url:

https://api.istex.fr/document/FB890763DD020CDFE4B4FC9F1CFEEE904A0C53E3/fulltext/pdf

DOI: 10.1016/0022-510X(88)90106-2

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The densities of D1- and D2-type dopamine receptors were measured with [3H]SCH23390 and [3H]spiperone, in the caudate nucleus and putamen of a large series of patients with Parkinson's disease or progressive supranuclear palsy, in relation to markers of dopaminergic and cholinergic innervation of the striatum ([3H]dihydrotetrabenazine binding and choline acetyltransferase activity). Correlations were sought between these parameters and clinical characteristics of the patients (abnormal involuntary movements, dementia, confusional syndrome or treatment).In Parkinson's disease, the densities of both types of receptors were unchanged, whereas in PSP, the density of D2, but not D1-type dopamine receptors, was decreased in the caudate nucleus and the putamen. No correlations between the biochemical and clinical data were found.</div>
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D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy

D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy

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Abstract

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