The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
Identifieur interne : 000A09 ( Main/Curation ); précédent : 000A08; suivant : 000A10The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
Auteurs : Pablo Martinez-Martin [Espagne] ; Carmen Rodriguez-Blazquez [Espagne] ; Monica M. Kurtis [Espagne] ; K. Ray Chaudhuri [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
English descriptors
- KwdEn :
Abstract
Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23462
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B51
Links to Exploration step
ISTEX:1085E7D886BB491D7DE6A95F31C94E0635468F47Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><author><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="1"><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Lazquez, Carmen" sort="Rodriguez Lazquez, Carmen" uniqKey="Rodriguez Lazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name><affiliation wicri:level="1"><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Kurtis, Monica M" sort="Kurtis, Monica M" uniqKey="Kurtis M" first="Monica M." last="Kurtis">Monica M. Kurtis</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation wicri:level="1"><mods:affiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, Kings College, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23462</idno><idno type="url">https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000B51</idno><idno type="wicri:Area/Main/Curation">000A09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><author><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="1"><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Lazquez, Carmen" sort="Rodriguez Lazquez, Carmen" uniqKey="Rodriguez Lazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name><affiliation wicri:level="1"><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Kurtis, Monica M" sort="Kurtis, Monica M" uniqKey="Kurtis M" first="Monica M." last="Kurtis">Monica M. Kurtis</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation wicri:level="1"><mods:affiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, Kings College, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="399">399</biblScope><biblScope unit="page" to="406">406</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><idno type="DOI">10.1002/mds.23462</idno><idno type="ArticleID">MDS23462</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>EQ‐5D</term><term>Parkinson's disease</term><term>Parkinson's disease questionnaire‐39 items</term><term>assessment</term><term>health‐related quality of life</term><term>non motor symptoms scale</term><term>non‐motor symptoms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000A09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:1085E7D886BB491D7DE6A95F31C94E0635468F47
|texte= The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |