The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
Identifieur interne : 000B51 ( Main/Corpus ); précédent : 000B50; suivant : 000B52The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
Auteurs : Pablo Martinez-Martin ; Carmen Rodriguez-Blazquez ; Monica M. Kurtis ; K. Ray ChaudhuriSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
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Abstract
Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23462
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><author><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Lazquez, Carmen" sort="Rodriguez Lazquez, Carmen" uniqKey="Rodriguez Lazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name><affiliation><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Kurtis, Monica M" sort="Kurtis, Monica M" uniqKey="Kurtis M" first="Monica M." last="Kurtis">Monica M. Kurtis</name><affiliation><mods:affiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation><mods:affiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23462</idno><idno type="url">https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000B51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><author><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Lazquez, Carmen" sort="Rodriguez Lazquez, Carmen" uniqKey="Rodriguez Lazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name><affiliation><mods:affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Kurtis, Monica M" sort="Kurtis, Monica M" uniqKey="Kurtis M" first="Monica M." last="Kurtis">Monica M. Kurtis</name><affiliation><mods:affiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation><mods:affiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="399">399</biblScope><biblScope unit="page" to="406">406</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><idno type="DOI">10.1002/mds.23462</idno><idno type="ArticleID">MDS23462</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>EQ‐5D</term><term>Parkinson's disease</term><term>Parkinson's disease questionnaire‐39 items</term><term>assessment</term><term>health‐related quality of life</term><term>non motor symptoms scale</term><term>non‐motor symptoms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Pablo Martinez‐Martin MD, PhD</name><affiliations><json:string>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</json:string><json:string>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Carmen Rodriguez‐Blazquez BS</name><affiliations><json:string>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Monica M. Kurtis MD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</json:string></affiliations></json:item><json:item><name>K. Ray Chaudhuri MD, FRCP, DSC</name><affiliations><json:string>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</json:string><json:string>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>non‐motor symptoms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>health‐related quality of life</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>assessment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>non motor symptoms scale</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease questionnaire‐39 items</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>EQ‐5D</value></json:item></subject><articleId><json:string>MDS23462</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.595</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1805</abstractCharCount><pdfWordCount>4595</pdfWordCount><pdfCharCount>32119</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>269</abstractWordCount></qualityIndicators><title>The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><corporate><json:item><name>on Behalf of the NMSS Validation Group</name></json:item></corporate><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>406</last><first>399</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23462</json:string></doi><id>1085E7D886BB491D7DE6A95F31C94E0635468F47</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note>Author Roles and Disclosures</note><note type="content">*Relevant conflict of interest/financial disclosure: Nothing to report. Full financial disclosure and author roles may be found in the online version of this article.</note><note type="content">*Members of the NMSS Validation Group are listed as an Appendix.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><author><orgName>on Behalf of the NMSS Validation Group</orgName></author><author><persName><forename type="first">Pablo</forename><surname>Martinez‐Martin</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: National Centre of Epidemiology, Carlos III Institute of Health, Av. Monforte de Lemos, 5. Madrid 28029, Spain</p></note><affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</affiliation><affiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</affiliation></author><author><persName><forename type="first">Carmen</forename><surname>Rodriguez‐Blazquez</surname></persName><roleName type="degree">BS</roleName><affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</affiliation></author><author><persName><forename type="first">Monica M.</forename><surname>Kurtis</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</affiliation></author><author><persName><forename type="first">K. Ray</forename><surname>Chaudhuri</surname></persName><roleName type="degree">MD, FRCP, DSC</roleName><affiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</affiliation><affiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="399">399</biblScope><biblScope unit="page" to="406">406</biblScope></imprint></monogr><idno type="istex">1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><idno type="DOI">10.1002/mds.23462</idno><idno type="ArticleID">MDS23462</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>non‐motor symptoms</term></item><item><term>health‐related quality of life</term></item><item><term>Parkinson's disease</term></item><item><term>assessment</term></item><item><term>non motor symptoms scale</term></item><item><term>Parkinson's disease questionnaire‐39 items</term></item><item><term>EQ‐5D</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-07-07">Received</change><change when="2010-09-07">Registration</change><change when="2011-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Madrid 28029, Spain</correspondenceTo><objectNameGroup><objectName elementName="appendix">APPENDIX</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23462.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="6"></count><count type="referenceTotal" number="41"></count><count type="wordTotal" number="7664"></count></countGroup><titleGroup><title type="main" xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease<link href="#fn4"></link><link href="#fn5"></link></title><title type="short" xml:lang="en">Nms and HRQ<sc>O</sc>L in Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Pablo</givenNames><familyName>Martinez‐Martin</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>pmartinez@isciii.es</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Carmen</givenNames><familyName>Rodriguez‐Blazquez</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Monica M.</givenNames><familyName>Kurtis</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4 #af5"><personName><givenNames>K. Ray</givenNames><familyName>Chaudhuri</familyName><degrees>MD, FRCP, DSC</degrees></personName></creator><creator xml:id="au5" creatorRole="author"><groupName>on Behalf of the NMSS Validation Group</groupName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="ES" type="organization"><unparsedAffiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="ES" type="organization"><unparsedAffiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="ES" type="organization"><unparsedAffiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">non‐motor symptoms</keyword><keyword xml:id="kwd2">health‐related quality of life</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">assessment</keyword><keyword xml:id="kwd5">non motor symptoms scale</keyword><keyword xml:id="kwd6">Parkinson's disease questionnaire‐39 items</keyword><keyword xml:id="kwd7">EQ‐5D</keyword></keywordGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23462:MDS_23462_sm_authorroles"></mediaResource><caption>Author Roles and Disclosures</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (<i>r</i><sub>S</sub> = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (<i>r</i><sub>S</sub> = 0.58); (2) showed high‐moderate correlation (<i>r</i><sub>S</sub> = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms.</p></section><section xml:id="abs1-4"><title type="main">Discussion:</title><p>To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn4"><p><b>Relevant conflict of interest/financial disclosure:</b> Nothing to report. Full financial disclosure and author roles may be found in the online version of this article.</p></note><note xml:id="fn5"><p>Members of the NMSS Validation Group are listed as an Appendix.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Nms and HRQOL in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Pablo</namePart><namePart type="family">Martinez‐Martin</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</affiliation><affiliation>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain</affiliation><description>Correspondence: National Centre of Epidemiology, Carlos III Institute of Health, Av. Monforte de Lemos, 5. Madrid 28029, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmen</namePart><namePart type="family">Rodriguez‐Blazquez</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Monica M.</namePart><namePart type="family">Kurtis</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. Ray</namePart><namePart type="family">Chaudhuri</namePart><namePart type="termsOfAddress">MD, FRCP, DSC</namePart><affiliation>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom</affiliation><affiliation>Department of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on Behalf of the NMSS Validation Group</namePart><description>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, SpainScientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, SpainMovement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid, SpainNational Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United KingdomDepartment of Neurology, University Hospital Lewisham, Kings College, London, United Kingdom</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-02-15</dateIssued><dateCaptured encoding="w3cdtf">2010-07-07</dateCaptured><dateValid encoding="w3cdtf">2010-09-07</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">6</extent><extent unit="references">41</extent><extent unit="words">7664</extent></physicalDescription><abstract lang="en">Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</abstract><note type="additional physical form">Author Roles and Disclosures</note><note type="content">*Relevant conflict of interest/financial disclosure: Nothing to report. Full financial disclosure and author roles may be found in the online version of this article.</note><note type="content">*Members of the NMSS Validation Group are listed as an Appendix.</note><subject lang="en"><genre>Keywords</genre><topic>non‐motor symptoms</topic><topic>health‐related quality of life</topic><topic>Parkinson's disease</topic><topic>assessment</topic><topic>non motor symptoms scale</topic><topic>Parkinson's disease questionnaire‐39 items</topic><topic>EQ‐5D</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>399</start><end>406</end><total>8</total></extent></part></relatedItem><identifier type="istex">1085E7D886BB491D7DE6A95F31C94E0635468F47</identifier><identifier type="DOI">10.1002/mds.23462</identifier><identifier type="ArticleID">MDS23462</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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