A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
Identifieur interne : 000848 ( Main/Curation ); précédent : 000847; suivant : 000849A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
Auteurs : Shuang Yong Ma [Finlande] ; Juha O. Rinne [Finlande] ; Yrjö Collan [Finlande] ; Matias Röytt [Finlande] ; Urpo K. Rinne [Finlande]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1996.
Abstract
We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.
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DOI: 10.1016/0022-510X(96)00069-X
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Juha O. Rinne<affiliation><mods:affiliation>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</mods:affiliation><wicri:noCountry code="no comma">Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation>Le document en format XML
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Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/0022-510X(96)00069-X</idno><idno type="url">https://api.istex.fr/document/B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000975</idno><idno type="wicri:Area/Main/Curation">000848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</title><author><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><affiliation><mods:affiliation>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</mods:affiliation><wicri:noCountry code="no comma">Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">140</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="40">40</biblScope><biblScope unit="page" to="45">45</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B</idno><idno type="DOI">10.1016/0022-510X(96)00069-X</idno><idno type="PII">0022-510X(96)00069-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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