A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
Identifieur interne : 000975 ( Main/Corpus ); précédent : 000974; suivant : 000976A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
Auteurs : Shuang Yong Ma ; Juha O. Rinne ; Yrjö Collan ; Matias Röytt ; Urpo K. RinneSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1996.
Abstract
We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.
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DOI: 10.1016/0022-510X(96)00069-X
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</title><author><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><affiliation><mods:affiliation>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/0022-510X(96)00069-X</idno><idno type="url">https://api.istex.fr/document/B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000975</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</title><author><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><affiliation><mods:affiliation>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">140</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="40">40</biblScope><biblScope unit="page" to="45">45</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B</idno><idno type="DOI">10.1016/0022-510X(96)00069-X</idno><idno type="PII">0022-510X(96)00069-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Shuang Yong Ma</name><affiliations><json:string>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Juha O. Rinne</name><affiliations><json:string>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</json:string><json:string>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Yrjö Collan</name><affiliations><json:string>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Matias Röyttä</name><affiliations><json:string>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Urpo K. Rinne</name><affiliations><json:string>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clinical section</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuromorphometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cell size</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuropathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Substantia nigra</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</abstract><qualityIndicators><score>6.968</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1624</abstractCharCount><pdfWordCount>3968</pdfWordCount><pdfCharCount>23535</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>269</abstractWordCount></qualityIndicators><title>A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</title><pii><json:string>0022-510X(96)00069-X</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>87</volume><pages><last>650</last><first>643</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Proc. 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Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</affiliation><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Yrjö</forename><surname>Collan</surname></persName><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Matias</forename><surname>Röyttä</surname></persName><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Urpo K.</forename><surname>Rinne</surname></persName><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation></author></analytic><monogr><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="pISSN">0022-510X</idno><idno type="PII">S0022-510X(00)X0019-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">140</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="40">40</biblScope><biblScope unit="page" to="45">45</biblScope></imprint></monogr><idno type="istex">B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B</idno><idno type="DOI">10.1016/0022-510X(96)00069-X</idno><idno type="PII">0022-510X(96)00069-X</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</p></abstract><textClass><keywords scheme="keyword"><list><head>Article category</head><item><term>Clinical section</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Neuromorphometry</term></item><item><term>Cell size</term></item><item><term>Neuropathology</term></item><item><term>Substantia nigra</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-02-24">Registration</change><change when="1996-01-30">Modified</change><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNS</jid><aid>9600069X</aid><ce:pii>0022-510X(96)00069-X</ce:pii><ce:doi>10.1016/0022-510X(96)00069-X</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Clinical section</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:dochead><ce:textfn>Research article</ce:textfn></ce:dochead><ce:title>A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</ce:title><ce:author-group><ce:author><ce:given-name>Shuang Yong</ce:given-name><ce:surname>Ma</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Juha O.</ce:given-name><ce:surname>Rinne</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yrjö</ce:given-name><ce:surname>Collan</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Matias</ce:given-name><ce:surname>Röyttä</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Urpo K.</ce:given-name><ce:surname>Rinne</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="9" month="5" year="1995"></ce:date-received><ce:date-revised day="30" month="1" year="1996"></ce:date-revised><ce:date-accepted day="24" month="2" year="1996"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Neuromorphometry</ce:text></ce:keyword><ce:keyword><ce:text>Cell size</ce:text></ce:keyword><ce:keyword><ce:text>Neuropathology</ce:text></ce:keyword><ce:keyword><ce:text>Substantia nigra</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Shuang Yong</namePart><namePart type="family">Ma</namePart><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juha O.</namePart><namePart type="family">Rinne</namePart><affiliation>Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</affiliation><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yrjö</namePart><namePart type="family">Collan</namePart><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matias</namePart><namePart type="family">Röyttä</namePart><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Urpo K.</namePart><namePart type="family">Rinne</namePart><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><dateValid encoding="w3cdtf">1996-02-24</dateValid><dateModified encoding="w3cdtf">1996-01-30</dateModified><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</abstract><note type="content">Section title: Research article</note><subject><genre>Article category</genre><topic>Clinical section</topic></subject><subject><genre>Keywords</genre><topic>Neuromorphometry</topic><topic>Cell size</topic><topic>Neuropathology</topic><topic>Substantia nigra</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title></titleInfo><titleInfo type="abbreviated"><title>JNS</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19960901</dateIssued></originInfo><identifier type="ISSN">0022-510X</identifier><identifier type="PII">S0022-510X(00)X0019-6</identifier><part><date>19960901</date><detail type="volume"><number>140</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>147</end></extent><extent unit="pages"><start>40</start><end>45</end></extent></part></relatedItem><identifier type="istex">B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B</identifier><identifier type="DOI">10.1016/0022-510X(96)00069-X</identifier><identifier type="PII">0022-510X(96)00069-X</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/B3DA9ADFCD2F780AC8C4F031D352DEF6AB3DEA6B/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROIMAGING</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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