The Management of Parkinson's Disease
Identifieur interne : 002835 ( Main/Corpus ); précédent : 002834; suivant : 002836The Management of Parkinson's Disease
Auteurs : J. G. L. MorrisSource :
- Australian and New Zealand Journal of Medicine [ 0004-8291 ] ; 1982-04.
Abstract
Abstract: Continuing education–state of the art. The management of Parkinson's Disease. J. G. L. Morris, Aust. N.Z. J. Med., 1982, 12, pp. 195–205. It is useful to divide Parkinsonian patients into those whose signs are confined to tremor, rigidity and akinesia, and those with evidence of a more diffuse disturbance. The treatment of choice in the former is levodopa combined with a peripheral decarboxylase inhibitor. At the onset of the disease, when disability is minimal, amantadine or anticholinergic drugs may suffice. Bromocriptine is useful in some patients who derive only short–lived benefit from each dose of levodopa. The role of stereotactic surgery is now confined to patients with an incapacitating unilateral tremor which has not improved with drug therapy. In elderly patients with evidence of diffuse cerebral dysfunction such as dementia, grasp reflex, hyper–reflexia or severe postural hypotension, the beneficial effect of these drugs is often outweighed by the side effects. Small doses of levodopa alone may be tried. Anti– cholinergic drugs and amantadine should be avoided in such patients.
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DOI: 10.1111/j.1445-5994.1982.tb02460.x
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The management of Parkinson's Disease. J. G. L. Morris, Aust. N.Z. J. Med., 1982, 12, pp. 195–205. It is useful to divide Parkinsonian patients into those whose signs are confined to tremor, rigidity and akinesia, and those with evidence of a more diffuse disturbance. The treatment of choice in the former is levodopa combined with a peripheral decarboxylase inhibitor. At the onset of the disease, when disability is minimal, amantadine or anticholinergic drugs may suffice. Bromocriptine is useful in some patients who derive only short–lived benefit from each dose of levodopa. The role of stereotactic surgery is now confined to patients with an incapacitating unilateral tremor which has not improved with drug therapy. In elderly patients with evidence of diffuse cerebral dysfunction such as dementia, grasp reflex, hyper–reflexia or severe postural hypotension, the beneficial effect of these drugs is often outweighed by the side effects. Small doses of levodopa alone may be tried. Anti– cholinergic drugs and amantadine should be avoided in such patients.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J. G. L. Morris</name><affiliations><json:string>Department of Neurology, Westmead Centre, Sydney</json:string></affiliations></json:item></author><articleId><json:string>IMJ195</json:string></articleId><language><json:string>eng</json:string></language><abstract>Abstract: Continuing education–state of the art. The management of Parkinson's Disease. J. G. L. Morris, Aust. N.Z. J. Med., 1982, 12, pp. 195–205. It is useful to divide Parkinsonian patients into those whose signs are confined to tremor, rigidity and akinesia, and those with evidence of a more diffuse disturbance. The treatment of choice in the former is levodopa combined with a peripheral decarboxylase inhibitor. At the onset of the disease, when disability is minimal, amantadine or anticholinergic drugs may suffice. Bromocriptine is useful in some patients who derive only short–lived benefit from each dose of levodopa. The role of stereotactic surgery is now confined to patients with an incapacitating unilateral tremor which has not improved with drug therapy. In elderly patients with evidence of diffuse cerebral dysfunction such as dementia, grasp reflex, hyper–reflexia or severe postural hypotension, the beneficial effect of these drugs is often outweighed by the side effects. Small doses of levodopa alone may be tried. 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L.</namePart><namePart type="family">Morris</namePart><affiliation>Department of Neurology, Westmead Centre, Sydney</affiliation><description>*Staff Neurologist.</description><description>Correspondence: Department of Neurology, Westmead Centre, Westmead, NSW 2145</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="other" displayLabel="miscellaneous"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1982-04</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">118</extent></physicalDescription><abstract lang="en">Abstract: Continuing education–state of the art. 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