Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
Identifieur interne : 002834 ( Main/Corpus ); précédent : 002833; suivant : 002835Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
Auteurs : Avner Shahar ; Kushang V. Patel ; Richard D. Semba ; Stefania Bandinelli ; Danit R. Shahar ; Louigi Ferrucci ; Jack M. GuralnikSource :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
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Abstract
Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23218
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Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Avner Shahar MD, MPH</name><affiliations><json:string>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</json:string><json:string>South district Geriatric Physician, Ministry of Health, Beer‐Sheva, Israel</json:string></affiliations></json:item><json:item><name>Kushang V. Patel PhD</name><affiliations><json:string>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</json:string></affiliations></json:item><json:item><name>Richard D. 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Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. 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Patel contributed equally to this work.</note><affiliation>Avner Shahar and Kushang V. Patel contributed equally to this work.</affiliation><note type="correspondence"><p>Correspondence: 5 Kibbutz Galuyot St., Gedera, 70700, Israel</p></note><affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</affiliation><affiliation>South district Geriatric Physician, Ministry of Health, Beer‐Sheva, Israel</affiliation></author><author><persName><forename type="first">Kushang V.</forename><surname>Patel</surname></persName><roleName type="degree">PhD</roleName><note type="biography">Avner Shahar and Kushang V. Patel contributed equally to this work.</note><affiliation>Avner Shahar and Kushang V. 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Daniel Abraham International Center for health and Nutrition, Ben‐Gurion University of the Negev, Beer‐Sheva, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">selenium</keyword><keyword xml:id="kwd2">trace elements</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">antioxidants</keyword><keyword xml:id="kwd5">elderly</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn4"><p>Potential conflict of interest: Nothing to report.</p></note><note xml:id="fn5"><p>Avner Shahar and Kushang V. Patel contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Effects of Selenium on SN Dysfunction</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed</title></titleInfo><name type="personal"><namePart type="given">Avner</namePart><namePart type="family">Shahar</namePart><namePart type="termsOfAddress">MD, MPH</namePart><affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</affiliation><affiliation>South district Geriatric Physician, Ministry of Health, Beer‐Sheva, Israel</affiliation><description>Avner Shahar and Kushang V. Patel contributed equally to this work.</description><description>Correspondence: 5 Kibbutz Galuyot St., Gedera, 70700, Israel</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kushang V.</namePart><namePart type="family">Patel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</affiliation><description>Avner Shahar and Kushang V. Patel contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard D.</namePart><namePart type="family">Semba</namePart><namePart type="termsOfAddress">MD, MPH</namePart><affiliation>Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefania</namePart><namePart type="family">Bandinelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Danit R.</namePart><namePart type="family">Shahar</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</affiliation><affiliation>The S. Daniel Abraham International Center for health and Nutrition, Ben‐Gurion University of the Negev, Beer‐Sheva, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Louigi</namePart><namePart type="family">Ferrucci</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jack M.</namePart><namePart type="family">Guralnik</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-09-15</dateIssued><dateCaptured encoding="w3cdtf">2009-09-16</dateCaptured><dateValid encoding="w3cdtf">2010-04-02</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">32</extent><extent unit="words">4912</extent></physicalDescription><abstract lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>selenium</topic><topic>trace elements</topic><topic>Parkinson's disease</topic><topic>antioxidants</topic><topic>elderly</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1909</start><end>1915</end><total>7</total></extent></part></relatedItem><identifier type="istex">77B47EEB9950D60C81C8C6D5DC30F1C892A2C7AE</identifier><identifier type="DOI">10.1002/mds.23218</identifier><identifier type="ArticleID">MDS23218</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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