Parkinson's disease: A case‐control study of occupational and environmental risk factors
Identifieur interne : 001E71 ( Main/Corpus ); précédent : 001E70; suivant : 001E72Parkinson's disease: A case‐control study of occupational and environmental risk factors
Auteurs : Clyde Hertzman ; Michele Wiens ; David Bowering ; Barry Snow ; Donald CalneSource :
- American Journal of Industrial Medicine [ 0271-3586 ] ; 1990.
English descriptors
Abstract
We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.
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DOI: 10.1002/ajim.4700170307
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<affiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</affiliation>
<affiliation>Current Address: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Michele</namePart>
<namePart type="family">Wiens</namePart>
<namePart type="termsOfAddress">MA</namePart>
<affiliation>Skeena Health Unit, Terrace, B.C. (D.B.)</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">David</namePart>
<namePart type="family">Bowering</namePart>
<namePart type="termsOfAddress">Md, Mhsc</namePart>
<affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Barry</namePart>
<namePart type="family">Snow</namePart>
<namePart type="termsOfAddress">Mbchb, Fracp</namePart>
<affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Donald</namePart>
<namePart type="family">Calne</namePart>
<namePart type="termsOfAddress">Dm, Frcp, Frcpc</namePart>
<affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="article" displayLabel="article"></genre>
<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">New York</placeTerm>
</place>
<dateIssued encoding="w3cdtf">1990</dateIssued>
<dateValid encoding="w3cdtf">1989-09-20</dateValid>
<copyrightDate encoding="w3cdtf">1990</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
<extent unit="tables">3</extent>
<extent unit="references">36</extent>
</physicalDescription>
<abstract lang="en">We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>environmental exposure</topic>
<topic>occupational exposure</topic>
<topic>pesticides</topic>
<topic>toxins</topic>
</subject>
<relatedItem type="host"><titleInfo><title>American Journal of Industrial Medicine</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Am. J. Ind. Med.</title>
</titleInfo>
<genre type="Journal">journal</genre>
<subject><genre>article category</genre>
<topic>Article</topic>
</subject>
<identifier type="ISSN">0271-3586</identifier>
<identifier type="eISSN">1097-0274</identifier>
<identifier type="DOI">10.1002/(ISSN)1097-0274</identifier>
<identifier type="PublisherID">AJIM</identifier>
<part><date>1990</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>349</start>
<end>355</end>
<total>7</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">EF352F2A72BCA6CD2D67DD99D63A7850D44F6506</identifier>
<identifier type="DOI">10.1002/ajim.4700170307</identifier>
<identifier type="ArticleID">AJIM4700170307</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company</accessCondition>
<recordInfo><recordContentSource>WILEY</recordContentSource>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
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