Parkinson's disease: A case‐control study of occupational and environmental risk factors
Identifieur interne : 001E71 ( Main/Corpus ); précédent : 001E70; suivant : 001E72Parkinson's disease: A case‐control study of occupational and environmental risk factors
Auteurs : Clyde Hertzman ; Michele Wiens ; David Bowering ; Barry Snow ; Donald CalneSource :
- American Journal of Industrial Medicine [ 0271-3586 ] ; 1990.
English descriptors
Abstract
We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.
Url:
DOI: 10.1002/ajim.4700170307
Links to Exploration step
ISTEX:EF352F2A72BCA6CD2D67DD99D63A7850D44F6506Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease: A case‐control study of occupational and environmental risk factors</title><author><name sortKey="Hertzman, Clyde" sort="Hertzman, Clyde" uniqKey="Hertzman C" first="Clyde" last="Hertzman">Clyde Hertzman</name><affiliation><mods:affiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</mods:affiliation></affiliation></author><author><name sortKey="Wiens, Michele" sort="Wiens, Michele" uniqKey="Wiens M" first="Michele" last="Wiens">Michele Wiens</name><affiliation><mods:affiliation>Skeena Health Unit, Terrace, B.C. (D.B.)</mods:affiliation></affiliation></author><author><name sortKey="Bowering, David" sort="Bowering, David" uniqKey="Bowering D" first="David" last="Bowering">David Bowering</name><affiliation><mods:affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</mods:affiliation></affiliation></author><author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name><affiliation><mods:affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</mods:affiliation></affiliation></author><author><name sortKey="Calne, Donald" sort="Calne, Donald" uniqKey="Calne D" first="Donald" last="Calne">Donald Calne</name><affiliation><mods:affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EF352F2A72BCA6CD2D67DD99D63A7850D44F6506</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1002/ajim.4700170307</idno><idno type="url">https://api.istex.fr/document/EF352F2A72BCA6CD2D67DD99D63A7850D44F6506/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease: A case‐control study of occupational and environmental risk factors</title><author><name sortKey="Hertzman, Clyde" sort="Hertzman, Clyde" uniqKey="Hertzman C" first="Clyde" last="Hertzman">Clyde Hertzman</name><affiliation><mods:affiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</mods:affiliation></affiliation></author><author><name sortKey="Wiens, Michele" sort="Wiens, Michele" uniqKey="Wiens M" first="Michele" last="Wiens">Michele Wiens</name><affiliation><mods:affiliation>Skeena Health Unit, Terrace, B.C. (D.B.)</mods:affiliation></affiliation></author><author><name sortKey="Bowering, David" sort="Bowering, David" uniqKey="Bowering D" first="David" last="Bowering">David Bowering</name><affiliation><mods:affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</mods:affiliation></affiliation></author><author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name><affiliation><mods:affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</mods:affiliation></affiliation></author><author><name sortKey="Calne, Donald" sort="Calne, Donald" uniqKey="Calne D" first="Donald" last="Calne">Donald Calne</name><affiliation><mods:affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Industrial Medicine</title><title level="j" type="abbrev">Am. J. Ind. Med.</title><idno type="ISSN">0271-3586</idno><idno type="eISSN">1097-0274</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1990">1990</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="349">349</biblScope><biblScope unit="page" to="355">355</biblScope></imprint><idno type="ISSN">0271-3586</idno></series><idno type="istex">EF352F2A72BCA6CD2D67DD99D63A7850D44F6506</idno><idno type="DOI">10.1002/ajim.4700170307</idno><idno type="ArticleID">AJIM4700170307</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0271-3586</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>environmental exposure</term><term>occupational exposure</term><term>pesticides</term><term>toxins</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Clyde Hertzman Md, Msc, Frcpc</name><affiliations><json:string>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</json:string><json:string>Current Address: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</json:string></affiliations></json:item><json:item><name>Michele Wiens MA</name><affiliations><json:string>Skeena Health Unit, Terrace, B.C. (D.B.)</json:string></affiliations></json:item><json:item><name>David Bowering Md, Mhsc</name><affiliations><json:string>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</json:string></affiliations></json:item><json:item><name>Barry Snow Mbchb, Fracp</name><affiliations><json:string>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</json:string></affiliations></json:item><json:item><name>Donald Calne Dm, Frcp, Frcpc</name><affiliations><json:string>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>environmental exposure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occupational exposure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pesticides</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>toxins</value></json:item></subject><articleId><json:string>AJIM4700170307</json:string></articleId><language><json:string>eng</json:string></language><abstract>We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.</abstract><qualityIndicators><score>4.773</score><pdfVersion>1.3</pdfVersion><pdfPageSize>481.92 x 708.48 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>799</abstractCharCount><pdfWordCount>3297</pdfWordCount><pdfCharCount>20339</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>123</abstractWordCount></qualityIndicators><title>Parkinson's disease: A case‐control study of occupational and environmental risk factors</title><genre><json:string>article</json:string></genre><host><volume>17</volume><publisherId><json:string>AJIM</json:string></publisherId><pages><total>7</total><last>355</last><first>349</first></pages><issn><json:string>0271-3586</json:string></issn><issue>3</issue><subject><json:item><value>Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1097-0274</json:string></eissn><title>American Journal of Industrial Medicine</title><doi><json:string>10.1002/(ISSN)1097-0274</json:string></doi></host><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1002/ajim.4700170307</json:string></doi><id>EF352F2A72BCA6CD2D67DD99D63A7850D44F6506</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/EF352F2A72BCA6CD2D67DD99D63A7850D44F6506/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/EF352F2A72BCA6CD2D67DD99D63A7850D44F6506/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/EF352F2A72BCA6CD2D67DD99D63A7850D44F6506/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Parkinson's disease: A case‐control study of occupational and environmental risk factors</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><p>WILEY</p></availability><date>1990</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease: A case‐control study of occupational and environmental risk factors</title><author><persName><forename type="first">Clyde</forename><surname>Hertzman</surname></persName><roleName type="degree">Md, Msc, Frcpc</roleName><affiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</affiliation><affiliation>Current Address: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</affiliation></author><author><persName><forename type="first">Michele</forename><surname>Wiens</surname></persName><roleName type="degree">MA</roleName><affiliation>Skeena Health Unit, Terrace, B.C. (D.B.)</affiliation></author><author><persName><forename type="first">David</forename><surname>Bowering</surname></persName><roleName type="degree">Md, Mhsc</roleName><affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation></author><author><persName><forename type="first">Barry</forename><surname>Snow</surname></persName><roleName type="degree">Mbchb, Fracp</roleName><affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation></author><author><persName><forename type="first">Donald</forename><surname>Calne</surname></persName><roleName type="degree">Dm, Frcp, Frcpc</roleName><affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation></author></analytic><monogr><title level="j">American Journal of Industrial Medicine</title><title level="j" type="abbrev">Am. J. Ind. Med.</title><idno type="pISSN">0271-3586</idno><idno type="eISSN">1097-0274</idno><idno type="DOI">10.1002/(ISSN)1097-0274</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1990"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="349">349</biblScope><biblScope unit="page" to="355">355</biblScope></imprint></monogr><idno type="istex">EF352F2A72BCA6CD2D67DD99D63A7850D44F6506</idno><idno type="DOI">10.1002/ajim.4700170307</idno><idno type="ArticleID">AJIM4700170307</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>environmental exposure</term></item><item><term>occupational exposure</term></item><item><term>pesticides</term></item><item><term>toxins</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1989-09-20">Registration</change><change when="1990">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/EF352F2A72BCA6CD2D67DD99D63A7850D44F6506/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1097-0274</doi><issn type="print">0271-3586</issn><issn type="electronic">1097-0274</issn><idGroup><id type="product" value="AJIM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="AMERICAN JOURNAL OF INDUSTRIAL MEDICINE">American Journal of Industrial Medicine</title><title type="short">Am. J. Ind. Med.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/ajim.v17:3</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="1990">1990</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="7" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ajim.4700170307</doi><idGroup><id type="unit" value="AJIM4700170307"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptAccepted" date="1989-09-20"></event><event type="firstOnline" date="2007-01-19"></event><event type="publishedOnlineFinalForm" date="2007-01-19"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-05"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">349</numbering><numbering type="pageLast">355</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:AJIM.AJIM4700170307.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="36"></count></countGroup><titleGroup><title type="main" xml:lang="en">Parkinson's disease: A case‐control study of occupational and environmental risk factors</title><title type="short" xml:lang="en">Factors for Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" currentRef="#curr1"><personName><givenNames>Clyde</givenNames><familyName>Hertzman</familyName><degrees>Md, Msc, Frcpc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Michele</givenNames><familyName>Wiens</familyName><degrees>MA</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>David</givenNames><familyName>Bowering</familyName><degrees>Md, Mhsc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Barry</givenNames><familyName>Snow</familyName><degrees>Mbchb, Fracp</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Donald</givenNames><familyName>Calne</familyName><degrees>Dm, Frcp, Frcpc</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Skeena Health Unit, Terrace, B.C. (D.B.)</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</unparsedAffiliation></affiliation><affiliation xml:id="curr1" countryCode="CA"><unparsedAffiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">environmental exposure</keyword><keyword xml:id="kwd3">occupational exposure</keyword><keyword xml:id="kwd4">pesticides</keyword><keyword xml:id="kwd5">toxins</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Parkinson's disease: A case‐control study of occupational and environmental risk factors</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Factors for Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinson's disease: A case‐control study of occupational and environmental risk factors</title></titleInfo><name type="personal"><namePart type="given">Clyde</namePart><namePart type="family">Hertzman</namePart><namePart type="termsOfAddress">Md, Msc, Frcpc</namePart><affiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, B.C. (C.H., M.W.)</affiliation><affiliation>Current Address: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C., Canada V6T 1W5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michele</namePart><namePart type="family">Wiens</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Skeena Health Unit, Terrace, B.C. (D.B.)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Bowering</namePart><namePart type="termsOfAddress">Md, Mhsc</namePart><affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barry</namePart><namePart type="family">Snow</namePart><namePart type="termsOfAddress">Mbchb, Fracp</namePart><affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald</namePart><namePart type="family">Calne</namePart><namePart type="termsOfAddress">Dm, Frcp, Frcpc</namePart><affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C. (B.S., D.C.)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1990</dateIssued><dateValid encoding="w3cdtf">1989-09-20</dateValid><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">36</extent></physicalDescription><abstract lang="en">We compared personal histories of 57 cases and 122 age‐matched controls to identify possible environmental determinants of Parkinson's disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% Cl = 0.91, 18.50). A Fisher's exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>environmental exposure</topic><topic>occupational exposure</topic><topic>pesticides</topic><topic>toxins</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Industrial Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Am. J. Ind. Med.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0271-3586</identifier><identifier type="eISSN">1097-0274</identifier><identifier type="DOI">10.1002/(ISSN)1097-0274</identifier><identifier type="PublisherID">AJIM</identifier><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>349</start><end>355</end><total>7</total></extent></part></relatedItem><identifier type="istex">EF352F2A72BCA6CD2D67DD99D63A7850D44F6506</identifier><identifier type="DOI">10.1002/ajim.4700170307</identifier><identifier type="ArticleID">AJIM4700170307</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E71 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001E71 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:EF352F2A72BCA6CD2D67DD99D63A7850D44F6506
|texte= Parkinson's disease: A case‐control study of occupational and environmental risk factors
}}
| This area was generated with Dilib version V0.6.23. |  |