Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy
Identifieur interne : 001B06 ( Main/Corpus ); précédent : 001B05; suivant : 001B07Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy
Auteurs : Loukia C. Tzarouchi ; Loukas G. Astrakas ; Spyridon Konitsiotis ; Sofia Tsouli ; Persefoni Margariti ; Anastasia Zikou ; Maria I. ArgyropoulouSource :
- Journal of Neuroimaging [ 1051-2284 ] ; 2010-07.
English descriptors
- KwdEn :
Abstract
ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.
Url:
DOI: 10.1111/j.1552-6569.2008.00343.x
Links to Exploration step
ISTEX:AE6F4D69030F53A0CEEEF6858F5A054F54C23C04Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title><author><name sortKey="Tzarouchi, Loukia C" sort="Tzarouchi, Loukia C" uniqKey="Tzarouchi L" first="Loukia C." last="Tzarouchi">Loukia C. Tzarouchi</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Astrakas, Loukas G" sort="Astrakas, Loukas G" uniqKey="Astrakas L" first="Loukas G." last="Astrakas">Loukas G. Astrakas</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Konitsiotis, Spyridon" sort="Konitsiotis, Spyridon" uniqKey="Konitsiotis S" first="Spyridon" last="Konitsiotis">Spyridon Konitsiotis</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Tsouli, Sofia" sort="Tsouli, Sofia" uniqKey="Tsouli S" first="Sofia" last="Tsouli">Sofia Tsouli</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Margariti, Persefoni" sort="Margariti, Persefoni" uniqKey="Margariti P" first="Persefoni" last="Margariti">Persefoni Margariti</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Zikou, Anastasia" sort="Zikou, Anastasia" uniqKey="Zikou A" first="Anastasia" last="Zikou">Anastasia Zikou</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Argyropoulou, Maria I" sort="Argyropoulou, Maria I" uniqKey="Argyropoulou M" first="Maria I." last="Argyropoulou">Maria I. Argyropoulou</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AE6F4D69030F53A0CEEEF6858F5A054F54C23C04</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1552-6569.2008.00343.x</idno><idno type="url">https://api.istex.fr/document/AE6F4D69030F53A0CEEEF6858F5A054F54C23C04/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001B06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title><author><name sortKey="Tzarouchi, Loukia C" sort="Tzarouchi, Loukia C" uniqKey="Tzarouchi L" first="Loukia C." last="Tzarouchi">Loukia C. Tzarouchi</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Astrakas, Loukas G" sort="Astrakas, Loukas G" uniqKey="Astrakas L" first="Loukas G." last="Astrakas">Loukas G. Astrakas</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Konitsiotis, Spyridon" sort="Konitsiotis, Spyridon" uniqKey="Konitsiotis S" first="Spyridon" last="Konitsiotis">Spyridon Konitsiotis</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Tsouli, Sofia" sort="Tsouli, Sofia" uniqKey="Tsouli S" first="Sofia" last="Tsouli">Sofia Tsouli</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Margariti, Persefoni" sort="Margariti, Persefoni" uniqKey="Margariti P" first="Persefoni" last="Margariti">Persefoni Margariti</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Zikou, Anastasia" sort="Zikou, Anastasia" uniqKey="Zikou A" first="Anastasia" last="Zikou">Anastasia Zikou</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author><author><name sortKey="Argyropoulou, Maria I" sort="Argyropoulou, Maria I" uniqKey="Argyropoulou M" first="Maria I." last="Argyropoulou">Maria I. Argyropoulou</name><affiliation><mods:affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimaging</title><idno type="ISSN">1051-2284</idno><idno type="eISSN">1552-6569</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-07">2010-07</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="260">260</biblScope><biblScope unit="page" to="266">266</biblScope></imprint><idno type="ISSN">1051-2284</idno></series><idno type="istex">AE6F4D69030F53A0CEEEF6858F5A054F54C23C04</idno><idno type="DOI">10.1111/j.1552-6569.2008.00343.x</idno><idno type="ArticleID">JON343</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1051-2284</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Magnetic resonance imaging</term><term>multiple system atrophy</term><term>voxel based morphometry</term><term>voxel based relaxometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Loukia C. Tzarouchi MD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item><json:item><name>Loukas G. Astrakas PhD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item><json:item><name>Spyridon Konitsiotis MD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item><json:item><name>Sofia Tsouli MD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item><json:item><name>Persefoni Margariti MD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item><json:item><name>Anastasia Zikou MD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item><json:item><name>Maria I. Argyropoulou MD</name><affiliations><json:string>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>voxel based morphometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>voxel based relaxometry</value></json:item></subject><articleId><json:string>JON343</json:string></articleId><language><json:string>eng</json:string></language><abstract>ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.</abstract><qualityIndicators><score>6.669</score><pdfVersion>1.4</pdfVersion><pdfPageSize>594 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1341</abstractCharCount><pdfWordCount>3781</pdfWordCount><pdfCharCount>24997</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>199</abstractWordCount></qualityIndicators><title>Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title><genre><json:string>article</json:string></genre><host><volume>20</volume><publisherId><json:string>JON</json:string></publisherId><pages><total>7</total><last>266</last><first>260</first></pages><issn><json:string>1051-2284</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1552-6569</json:string></eissn><title>Journal of Neuroimaging</title><doi><json:string>10.1111/(ISSN)1552-6569</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1111/j.1552-6569.2008.00343.x</json:string></doi><id>AE6F4D69030F53A0CEEEF6858F5A054F54C23C04</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AE6F4D69030F53A0CEEEF6858F5A054F54C23C04/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AE6F4D69030F53A0CEEEF6858F5A054F54C23C04/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AE6F4D69030F53A0CEEEF6858F5A054F54C23C04/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title><author><persName><forename type="first">Loukia C.</forename><surname>Tzarouchi</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author><author><persName><forename type="first">Loukas G.</forename><surname>Astrakas</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author><author><persName><forename type="first">Spyridon</forename><surname>Konitsiotis</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author><author><persName><forename type="first">Sofia</forename><surname>Tsouli</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author><author><persName><forename type="first">Persefoni</forename><surname>Margariti</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author><author><persName><forename type="first">Anastasia</forename><surname>Zikou</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author><author><persName><forename type="first">Maria I.</forename><surname>Argyropoulou</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation></author></analytic><monogr><title level="j">Journal of Neuroimaging</title><idno type="pISSN">1051-2284</idno><idno type="eISSN">1552-6569</idno><idno type="DOI">10.1111/(ISSN)1552-6569</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-07"></date><biblScope unit="volume">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="260">260</biblScope><biblScope unit="page" to="266">266</biblScope></imprint></monogr><idno type="istex">AE6F4D69030F53A0CEEEF6858F5A054F54C23C04</idno><idno type="DOI">10.1111/j.1552-6569.2008.00343.x</idno><idno type="ArticleID">JON343</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Magnetic resonance imaging</term></item><item><term>multiple system atrophy</term></item><item><term>voxel based morphometry</term></item><item><term>voxel based relaxometry</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AE6F4D69030F53A0CEEEF6858F5A054F54C23C04/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1552-6569</doi><issn type="print">1051-2284</issn><issn type="electronic">1552-6569</issn><idGroup><id type="product" value="JON"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF NEUROIMAGING">Journal of Neuroimaging</title></titleGroup></publicationMeta><publicationMeta level="part" position="07003"><doi origin="wiley">10.1111/jon.2010.20.issue-3</doi><numberingGroup><numbering type="journalVolume" number="20">20</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2010-07">July 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="12" status="forIssue"><doi origin="wiley">10.1111/j.1552-6569.2008.00343.x</doi><idGroup><id type="unit" value="JON343"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1"><i>CLINICAL INVESTIGATIVE STUDY</i></title></titleGroup><copyright>© 2009 by the American Society of Neuroimaging</copyright><eventGroup><event type="firstOnline" date="2009-01-29"></event><event type="publishedOnlineFinalForm" date="2010-07-12"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:FullText result:FullText" date="2010-07-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="260">260</numbering><numbering type="pageLast" number="266">266</numbering></numberingGroup><correspondenceTo><b>Correspondence</b>: Address correspondence to Maria I. Argyropoulou, MD, Professor of Radiology, Medical School University of Ioannina, 45110 Ioannina, Greece. E‐mail: <email>margyrop@cc.uoi.gr</email>.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JON.JON343.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory><b>Acceptance:</b> Received July 2, 2008, and in revised form September 11, 2008. Accepted for publication October 2, 2008.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="39"></count><count type="linksCrossRef" number="45"></count></countGroup><titleGroup><title type="main">Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Loukia C.</givenNames><familyName>Tzarouchi</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Loukas G.</givenNames><familyName>Astrakas</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Spyridon</givenNames><familyName>Konitsiotis</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Sofia</givenNames><familyName>Tsouli</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Persefoni</givenNames><familyName>Margariti</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Anastasia</givenNames><familyName>Zikou</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>Maria I.</givenNames><familyName>Argyropoulou</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GR"><unparsedAffiliation> Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.
[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Magnetic resonance imaging</keyword><keyword xml:id="k2">multiple system atrophy</keyword><keyword xml:id="k3">voxel based morphometry</keyword><keyword xml:id="k4">voxel based relaxometry</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="abs1-1"><title type="main">ABSTRACT</title></section><section xml:id="abs1-2"><title type="main">BACKGROUND AND PURPOSE</title><p> <b>Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P.</b> </p></section><section xml:id="abs1-3"><title type="main">METHODS</title><p> <b>Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied.</b> </p></section><section xml:id="abs1-4"><title type="main">RESULTS</title><p> <b>In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume.</b> </p></section><section xml:id="abs1-5"><title type="main">CONCLUSIONS</title><p> <b>Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.</b> </p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="n-fnt-1" numbered="no"><p>J Neuroimaging 2010;10:260‐266.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy</title></titleInfo><name type="personal"><namePart type="given">Loukia C.</namePart><namePart type="family">Tzarouchi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Loukas G.</namePart><namePart type="family">Astrakas</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Spyridon</namePart><namePart type="family">Konitsiotis</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sofia</namePart><namePart type="family">Tsouli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Persefoni</namePart><namePart type="family">Margariti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anastasia</namePart><namePart type="family">Zikou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria I.</namePart><namePart type="family">Argyropoulou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology (LCT, LGA, PM, AZ, MIA) and Department of Neurology (SK, ST), Medical School, University of Ioannina, Ioannina, Greece.[Correction added after online publication 27‐March‐2009: Author name has been corrected. Spyridon Kontsiotis should be spelled as Spyridon Konitsiotis, MD.]</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2010-07</dateIssued><edition>Acceptance: Received July 2, 2008, and in revised form September 11, 2008. Accepted for publication October 2, 2008.</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">4</extent><extent unit="references">39</extent></physicalDescription><abstract lang="en">ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.</abstract><subject lang="en"><genre>Keywords</genre><topic>Magnetic resonance imaging</topic><topic>multiple system atrophy</topic><topic>voxel based morphometry</topic><topic>voxel based relaxometry</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroimaging</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1051-2284</identifier><identifier type="eISSN">1552-6569</identifier><identifier type="DOI">10.1111/(ISSN)1552-6569</identifier><identifier type="PublisherID">JON</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>260</start><end>266</end><total>7</total></extent></part></relatedItem><identifier type="istex">AE6F4D69030F53A0CEEEF6858F5A054F54C23C04</identifier><identifier type="DOI">10.1111/j.1552-6569.2008.00343.x</identifier><identifier type="ArticleID">JON343</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 by the American Society of Neuroimaging</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001B06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:AE6F4D69030F53A0CEEEF6858F5A054F54C23C04
|texte= Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy
}}
| This area was generated with Dilib version V0.6.23. |  |