Compulsions, Parkinson's disease, and stimulation.
Identifieur interne : 001120 ( PubMed/Curation ); précédent : 001119; suivant : 001121Compulsions, Parkinson's disease, and stimulation.
Auteurs : Luc Mallet [France] ; Valérie Mesnage ; Jean-Luc Houeto ; Antoine Pelissolo ; Jérôme Yelnik ; Cécile Behar ; Marcella Gargiulo ; Marie-Laure Welter ; Anne-Marie Bonnet ; Bernard Pillon ; Philippe Cornu ; Didier Dormont ; Bernard Pidoux ; Jean-François Allilaire ; Yves AgidSource :
- Lancet (London, England) [ 0140-6736 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- complications : Obsessive-Compulsive Disorder, Parkinson Disease.
- therapy : Obsessive-Compulsive Disorder, Parkinson Disease.
- Electric Stimulation Therapy, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Subthalamic Nucleus.
Abstract
Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.
DOI: 10.1016/S0140-6736(02)11339-0
PubMed: 12414208
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pubmed:12414208Le document en format XML
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<front><div type="abstract" xml:lang="en">Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.</div>
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<Abstract><AbstractText>Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.</AbstractText>
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