Compulsions, Parkinson's disease, and stimulation.
Identifieur interne : 001161 ( PubMed/Corpus ); précédent : 001160; suivant : 001162Compulsions, Parkinson's disease, and stimulation.
Auteurs : Luc Mallet ; Valérie Mesnage ; Jean-Luc Houeto ; Antoine Pelissolo ; Jérôme Yelnik ; Cécile Behar ; Marcella Gargiulo ; Marie-Laure Welter ; Anne-Marie Bonnet ; Bernard Pillon ; Philippe Cornu ; Didier Dormont ; Bernard Pidoux ; Jean-François Allilaire ; Yves AgidSource :
- Lancet (London, England) [ 0140-6736 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- complications : Obsessive-Compulsive Disorder, Parkinson Disease.
- therapy : Obsessive-Compulsive Disorder, Parkinson Disease.
- Electric Stimulation Therapy, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Subthalamic Nucleus.
Abstract
Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.
DOI: 10.1016/S0140-6736(02)11339-0
PubMed: 12414208
Links to Exploration step
pubmed:12414208Le document en format XML
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sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name></author><author><name sortKey="Behar, Cecile" sort="Behar, Cecile" uniqKey="Behar C" first="Cécile" last="Behar">Cécile Behar</name></author><author><name sortKey="Gargiulo, Marcella" sort="Gargiulo, Marcella" uniqKey="Gargiulo M" first="Marcella" last="Gargiulo">Marcella Gargiulo</name></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name></author><author><name 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wicri:corpus="PubMed">001161</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Compulsions, Parkinson's disease, and stimulation.</title><author><name sortKey="Mallet, Luc" sort="Mallet, Luc" uniqKey="Mallet L" first="Luc" last="Mallet">Luc Mallet</name><affiliation><nlm:affiliation>CNRS UMR 7593 and Service de Psychiatrie, Pavillon Clérambault, GH Pitié-Salpêtrière, Hôpital de la Salpêtrière, Assistance Publique-Hôpital de Paris, 75651 Cedex 13, Paris, France. lucmallet@free.fr</nlm:affiliation></affiliation></author><author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></author><author><name sortKey="Pelissolo, Antoine" sort="Pelissolo, Antoine" uniqKey="Pelissolo A" first="Antoine" last="Pelissolo">Antoine Pelissolo</name></author><author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name></author><author><name sortKey="Behar, Cecile" sort="Behar, Cecile" uniqKey="Behar C" first="Cécile" last="Behar">Cécile Behar</name></author><author><name sortKey="Gargiulo, Marcella" sort="Gargiulo, Marcella" uniqKey="Gargiulo M" first="Marcella" last="Gargiulo">Marcella Gargiulo</name></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name></author><author><name sortKey="Allilaire, Jean Francois" sort="Allilaire, Jean Francois" uniqKey="Allilaire J" first="Jean-François" last="Allilaire">Jean-François Allilaire</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Obsessive-Compulsive Disorder (complications)</term><term>Obsessive-Compulsive Disorder (therapy)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obsessive-Compulsive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Obsessive-Compulsive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Subthalamic Nucleus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12414208</PMID><DateCreated><Year>2002</Year><Month>11</Month><Day>04</Day></DateCreated><DateCompleted><Year>2002</Year><Month>12</Month><Day>04</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0140-6736</ISSN><JournalIssue CitedMedium="Print"><Volume>360</Volume><Issue>9342</Issue><PubDate><Year>2002</Year><Month>Oct</Month><Day>26</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Compulsions, Parkinson's disease, and stimulation.</ArticleTitle><Pagination><MedlinePgn>1302-4</MedlinePgn></Pagination><Abstract><AbstractText>Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mallet</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CNRS UMR 7593 and Service de Psychiatrie, Pavillon Clérambault, GH Pitié-Salpêtrière, Hôpital de la Salpêtrière, Assistance Publique-Hôpital de Paris, 75651 Cedex 13, Paris, France. lucmallet@free.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mesnage</LastName><ForeName>Valérie</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Houeto</LastName><ForeName>Jean-Luc</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Pelissolo</LastName><ForeName>Antoine</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Yelnik</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Behar</LastName><ForeName>Cécile</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Gargiulo</LastName><ForeName>Marcella</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Welter</LastName><ForeName>Marie-Laure</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>Anne-Marie</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Pillon</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Cornu</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dormont</LastName><ForeName>Didier</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Pidoux</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Allilaire</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Agid</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="Y">Electric Stimulation Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004567" MajorTopicYN="N">Electrodes, Implanted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009771" MajorTopicYN="N">Obsessive-Compulsive Disorder</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>11</Month><Day>5</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>12</Month><Day>5</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>11</Month><Day>5</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12414208</ArticleId><ArticleId IdType="pii">S0140-6736(02)11339-0</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(02)11339-0</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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