Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.
Identifieur interne : 000D12 ( PubMed/Curation ); précédent : 000D11; suivant : 000D13Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.
Auteurs : A. Gerdelat-Mas [France] ; M. Simonetta-Moreau ; C. Thalamas ; F. Ory-Magne ; T. Slaoui ; O. Rascol ; C. Brefel-CourbonSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Levodopa.
- complications : Parkinson Disease.
- drug effects : Pain Threshold.
- drug therapy : Pain.
- etiology : Pain.
- physiopathology : Pain.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.
DOI: 10.1136/jnnp.2007.120212
PubMed: 17504881
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pubmed:17504881Le document en format XML
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<author><name sortKey="Gerdelat Mas, A" sort="Gerdelat Mas, A" uniqKey="Gerdelat Mas A" first="A" last="Gerdelat-Mas">A. Gerdelat-Mas</name>
<affiliation wicri:level="1"><nlm:affiliation>Fédération de Neuroscience, Hôpital Purpan, Toulouse, France. gerdelat-mas.a@chu-toulouse.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Fédération de Neuroscience, Hôpital Purpan, Toulouse</wicri:regionArea>
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<author><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name>
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<author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C" last="Thalamas">C. Thalamas</name>
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<author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F" last="Ory-Magne">F. Ory-Magne</name>
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<author><name sortKey="Slaoui, T" sort="Slaoui, T" uniqKey="Slaoui T" first="T" last="Slaoui">T. Slaoui</name>
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<author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name>
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<author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C" last="Brefel-Courbon">C. Brefel-Courbon</name>
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<author><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name>
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<author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C" last="Thalamas">C. Thalamas</name>
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<author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F" last="Ory-Magne">F. Ory-Magne</name>
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<author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C" last="Brefel-Courbon">C. Brefel-Courbon</name>
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<series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title>
<idno type="eISSN">1468-330X</idno>
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<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pain (drug therapy)</term>
<term>Pain (etiology)</term>
<term>Pain (physiopathology)</term>
<term>Pain Threshold (drug effects)</term>
<term>Parkinson Disease (complications)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pain Threshold</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pain</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pain</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Pain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.</div>
</front>
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<DateCreated><Year>2007</Year>
<Month>09</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2007</Year>
<Month>10</Month>
<Day>01</Day>
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<DateRevised><Year>2014</Year>
<Month>09</Month>
<Day>07</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-330X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>78</Volume>
<Issue>10</Issue>
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<Month>Oct</Month>
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<Title>Journal of neurology, neurosurgery, and psychiatry</Title>
<ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation>
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<ArticleTitle>Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.</ArticleTitle>
<Pagination><MedlinePgn>1140-2</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">The objective of this study was to assess and compare the effect of levodopa on the objective pain threshold in patients with PD and healthy subjects.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The objective pain threshold was assessed by the nociceptive flexion reflex (RIII) in 13 PD patients and 10 healthy subjects. Patients and healthy subjects were evaluated under two randomised conditions: with levodopa (ON) and without (OFF).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Levodopa significantly increased the RIII threshold of PD patients (6.9 (1.2) mA in the OFF condition vs 8 (1.1) mA in the ON position; p = 0.02). RIII threshold was significantly lower in PD patients than in healthy subjects in the OFF condition (6.9 (1.2) mA vs 9.7 (3.4) mA; p = 0.02). RIII threshold did not change after levodopa administration in healthy subjects.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These results provide evidence of a dopaminergic modulation of objective pain threshold in PD patients. In addition, the decrease in RIII threshold in PD patients, in the OFF condition, compared with controls, confirms the existence of an objective pain perception disturbance in PD.</AbstractText>
</Abstract>
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<Author ValidYN="Y"><LastName>Thalamas</LastName>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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