Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.
Identifieur interne : 000D52 ( PubMed/Corpus ); précédent : 000D51; suivant : 000D53Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.
Auteurs : A. Gerdelat-Mas ; M. Simonetta-Moreau ; C. Thalamas ; F. Ory-Magne ; T. Slaoui ; O. Rascol ; C. Brefel-CourbonSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Levodopa.
- complications : Parkinson Disease.
- drug effects : Pain Threshold.
- drug therapy : Pain.
- etiology : Pain.
- physiopathology : Pain.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.
DOI: 10.1136/jnnp.2007.120212
PubMed: 17504881
Links to Exploration step
pubmed:17504881Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.</title><author><name sortKey="Gerdelat Mas, A" sort="Gerdelat Mas, A" uniqKey="Gerdelat Mas A" first="A" last="Gerdelat-Mas">A. Gerdelat-Mas</name><affiliation><nlm:affiliation>Fédération de Neuroscience, Hôpital Purpan, Toulouse, France. gerdelat-mas.a@chu-toulouse.fr</nlm:affiliation></affiliation></author><author><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name></author><author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C" last="Thalamas">C. Thalamas</name></author><author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F" last="Ory-Magne">F. Ory-Magne</name></author><author><name sortKey="Slaoui, T" sort="Slaoui, T" uniqKey="Slaoui T" first="T" last="Slaoui">T. Slaoui</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C" last="Brefel-Courbon">C. Brefel-Courbon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17504881</idno><idno type="pmid">17504881</idno><idno type="doi">10.1136/jnnp.2007.120212</idno><idno type="wicri:Area/PubMed/Corpus">000D52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.</title><author><name sortKey="Gerdelat Mas, A" sort="Gerdelat Mas, A" uniqKey="Gerdelat Mas A" first="A" last="Gerdelat-Mas">A. Gerdelat-Mas</name><affiliation><nlm:affiliation>Fédération de Neuroscience, Hôpital Purpan, Toulouse, France. gerdelat-mas.a@chu-toulouse.fr</nlm:affiliation></affiliation></author><author><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name></author><author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C" last="Thalamas">C. Thalamas</name></author><author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F" last="Ory-Magne">F. Ory-Magne</name></author><author><name sortKey="Slaoui, T" sort="Slaoui, T" uniqKey="Slaoui T" first="T" last="Slaoui">T. Slaoui</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C" last="Brefel-Courbon">C. Brefel-Courbon</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="eISSN">1468-330X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Pain (drug therapy)</term><term>Pain (etiology)</term><term>Pain (physiopathology)</term><term>Pain Threshold (drug effects)</term><term>Parkinson Disease (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pain Threshold</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17504881</PMID><DateCreated><Year>2007</Year><Month>09</Month><Day>19</Day></DateCreated><DateCompleted><Year>2007</Year><Month>10</Month><Day>01</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-330X</ISSN><JournalIssue CitedMedium="Internet"><Volume>78</Volume><Issue>10</Issue><PubDate><Year>2007</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.</ArticleTitle><Pagination><MedlinePgn>1140-2</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.</AbstractText><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The objective of this study was to assess and compare the effect of levodopa on the objective pain threshold in patients with PD and healthy subjects.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The objective pain threshold was assessed by the nociceptive flexion reflex (RIII) in 13 PD patients and 10 healthy subjects. Patients and healthy subjects were evaluated under two randomised conditions: with levodopa (ON) and without (OFF).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Levodopa significantly increased the RIII threshold of PD patients (6.9 (1.2) mA in the OFF condition vs 8 (1.1) mA in the ON position; p = 0.02). RIII threshold was significantly lower in PD patients than in healthy subjects in the OFF condition (6.9 (1.2) mA vs 9.7 (3.4) mA; p = 0.02). RIII threshold did not change after levodopa administration in healthy subjects.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These results provide evidence of a dopaminergic modulation of objective pain threshold in PD patients. In addition, the decrease in RIII threshold in PD patients, in the OFF condition, compared with controls, confirms the existence of an objective pain perception disturbance in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gerdelat-Mas</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fédération de Neuroscience, Hôpital Purpan, Toulouse, France. gerdelat-mas.a@chu-toulouse.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonetta-Moreau</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Thalamas</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ory-Magne</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Slaoui</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Brefel-Courbon</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>05</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Clin Neurosci. 1998;5(2):63-72</RefSource><PMID Version="1">10785830</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rev Neurol (Paris). 2007 Jan;163(1):66-71</RefSource><PMID Version="1">17304174</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2004 Jun 22;62(12):2171-5</RefSource><PMID Version="1">15210877</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 1977 Feb;3(1):69-80</RefSource><PMID Version="1">876668</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 1979 Apr;6(2):207-15</RefSource><PMID Version="1">37473</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1984 Aug 25;2(8400):456-7</RefSource><PMID Version="1">6147516</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1986 Jun 14;1(8494):1366-9</RefSource><PMID Version="1">2872480</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52</RefSource><PMID Version="1">2841426</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Funct Neurol. 1989 Apr-Jun;4(2):199-202</RefSource><PMID Version="1">2737512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Jpn J Psychiatry Neurol. 1990 Sep;44(3):589-93</RefSource><PMID Version="1">1705999</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 1992 Nov;263(2):470-9</RefSource><PMID Version="1">1432683</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Life Sci. 1992;51(19):1485-92</RefSource><PMID Version="1">1435058</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rev Neurol (Paris). 1992;148(10):641-4</RefSource><PMID Version="1">1295061</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 1995 Jan;60(1):3-38</RefSource><PMID Version="1">7715939</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 1999 Mar;80(1-2):399-404</RefSource><PMID Version="1">10204754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rev Neurol (Paris). 2005 Apr;161(4):407-18</RefSource><PMID Version="1">15924076</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2005 Dec;20(12):1557-63</RefSource><PMID Version="1">16078219</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 2001 Feb 15;90(3):257-60</RefSource><PMID Version="1">11207397</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010146" MajorTopicYN="N">Pain</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017288" MajorTopicYN="N">Pain Threshold</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2117570</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>5</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>10</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>5</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17504881</ArticleId><ArticleId IdType="pii">jnnp.2007.120212</ArticleId><ArticleId IdType="doi">10.1136/jnnp.2007.120212</ArticleId><ArticleId IdType="pmc">PMC2117570</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D52 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000D52 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:17504881
|texte= Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:17504881" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |