Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.
Identifieur interne : 000923 ( PubMed/Corpus ); précédent : 000922; suivant : 000924Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.
Auteurs : Lei Wang ; Ji-Feng Guo ; Wen-Wen Zhang ; Qian Xu ; Xing Zuo ; Chang-He Shi ; Lin-Zi Luo ; Jia Liu ; Liang Hu ; Ya-Cen Hu ; Xin-Xiang Yan ; Bei-Sha TangSource :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [ 1532-2653 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Asian Continental Ancestry Group (genetics), Carrier Proteins (genetics), Case-Control Studies, China, Female, Follow-Up Studies, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parkinson Disease (genetics), Polymorphism, Single Nucleotide.
- MESH :
- chemical , genetics : Carrier Proteins.
- geographic : China.
- genetics : Asian Continental Ancestry Group, Parkinson Disease.
- Aged, Aged, 80 and over, Case-Control Studies, Female, Follow-Up Studies, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
The Grb10-interacting GYF protein-2 gene (GIGYF2) is a PARK11 gene that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France. However, no comprehensive study of the GIGYF2 gene has been conducted among PD patients from mainland China. In our previous study, the GIGYF2 gene was directly sequenced, and nine missense variants and 14 polymorphisms were identified. For these 14 polymorphisms, in the present study we performed a case–control analysis for 300 PD patients and 200 healthy controls from mainland China. The c.297T>C p.Ala99Ala polymorphism was associated with increased risk with respect to the pathogenesis of sporadic PD. In conclusion, within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing PD.
DOI: 10.1016/j.jocn.2011.05.014
PubMed: 22115759
Links to Exploration step
pubmed:22115759Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.</title>
<author><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name>
<affiliation><nlm:affiliation>Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guo, Ji Feng" sort="Guo, Ji Feng" uniqKey="Guo J" first="Ji-Feng" last="Guo">Ji-Feng Guo</name>
</author>
<author><name sortKey="Zhang, Wen Wen" sort="Zhang, Wen Wen" uniqKey="Zhang W" first="Wen-Wen" last="Zhang">Wen-Wen Zhang</name>
</author>
<author><name sortKey="Xu, Qian" sort="Xu, Qian" uniqKey="Xu Q" first="Qian" last="Xu">Qian Xu</name>
</author>
<author><name sortKey="Zuo, Xing" sort="Zuo, Xing" uniqKey="Zuo X" first="Xing" last="Zuo">Xing Zuo</name>
</author>
<author><name sortKey="Shi, Chang He" sort="Shi, Chang He" uniqKey="Shi C" first="Chang-He" last="Shi">Chang-He Shi</name>
</author>
<author><name sortKey="Luo, Lin Zi" sort="Luo, Lin Zi" uniqKey="Luo L" first="Lin-Zi" last="Luo">Lin-Zi Luo</name>
</author>
<author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name>
</author>
<author><name sortKey="Hu, Liang" sort="Hu, Liang" uniqKey="Hu L" first="Liang" last="Hu">Liang Hu</name>
</author>
<author><name sortKey="Hu, Ya Cen" sort="Hu, Ya Cen" uniqKey="Hu Y" first="Ya-Cen" last="Hu">Ya-Cen Hu</name>
</author>
<author><name sortKey="Yan, Xin Xiang" sort="Yan, Xin Xiang" uniqKey="Yan X" first="Xin-Xiang" last="Yan">Xin-Xiang Yan</name>
</author>
<author><name sortKey="Tang, Bei Sha" sort="Tang, Bei Sha" uniqKey="Tang B" first="Bei-Sha" last="Tang">Bei-Sha Tang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:22115759</idno>
<idno type="pmid">22115759</idno>
<idno type="doi">10.1016/j.jocn.2011.05.014</idno>
<idno type="wicri:Area/PubMed/Corpus">000923</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000923</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.</title>
<author><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name>
<affiliation><nlm:affiliation>Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guo, Ji Feng" sort="Guo, Ji Feng" uniqKey="Guo J" first="Ji-Feng" last="Guo">Ji-Feng Guo</name>
</author>
<author><name sortKey="Zhang, Wen Wen" sort="Zhang, Wen Wen" uniqKey="Zhang W" first="Wen-Wen" last="Zhang">Wen-Wen Zhang</name>
</author>
<author><name sortKey="Xu, Qian" sort="Xu, Qian" uniqKey="Xu Q" first="Qian" last="Xu">Qian Xu</name>
</author>
<author><name sortKey="Zuo, Xing" sort="Zuo, Xing" uniqKey="Zuo X" first="Xing" last="Zuo">Xing Zuo</name>
</author>
<author><name sortKey="Shi, Chang He" sort="Shi, Chang He" uniqKey="Shi C" first="Chang-He" last="Shi">Chang-He Shi</name>
</author>
<author><name sortKey="Luo, Lin Zi" sort="Luo, Lin Zi" uniqKey="Luo L" first="Lin-Zi" last="Luo">Lin-Zi Luo</name>
</author>
<author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name>
</author>
<author><name sortKey="Hu, Liang" sort="Hu, Liang" uniqKey="Hu L" first="Liang" last="Hu">Liang Hu</name>
</author>
<author><name sortKey="Hu, Ya Cen" sort="Hu, Ya Cen" uniqKey="Hu Y" first="Ya-Cen" last="Hu">Ya-Cen Hu</name>
</author>
<author><name sortKey="Yan, Xin Xiang" sort="Yan, Xin Xiang" uniqKey="Yan X" first="Xin-Xiang" last="Yan">Xin-Xiang Yan</name>
</author>
<author><name sortKey="Tang, Bei Sha" sort="Tang, Bei Sha" uniqKey="Tang B" first="Bei-Sha" last="Tang">Bei-Sha Tang</name>
</author>
</analytic>
<series><title level="j">Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia</title>
<idno type="eISSN">1532-2653</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Asian Continental Ancestry Group (genetics)</term>
<term>Carrier Proteins (genetics)</term>
<term>Case-Control Studies</term>
<term>China</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The Grb10-interacting GYF protein-2 gene (GIGYF2) is a PARK11 gene that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France. However, no comprehensive study of the GIGYF2 gene has been conducted among PD patients from mainland China. In our previous study, the GIGYF2 gene was directly sequenced, and nine missense variants and 14 polymorphisms were identified. For these 14 polymorphisms, in the present study we performed a case–control analysis for 300 PD patients and 200 healthy controls from mainland China. The c.297T>C p.Ala99Ala polymorphism was associated with increased risk with respect to the pathogenesis of sporadic PD. In conclusion, within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing PD.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22115759</PMID>
<DateCreated><Year>2012</Year>
<Month>01</Month>
<Day>05</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>07</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2012</Year>
<Month>01</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1532-2653</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>12</Issue>
<PubDate><Year>2011</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia</Title>
<ISOAbbreviation>J Clin Neurosci</ISOAbbreviation>
</Journal>
<ArticleTitle>Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.</ArticleTitle>
<Pagination><MedlinePgn>1699-701</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jocn.2011.05.014</ELocationID>
<Abstract><AbstractText>The Grb10-interacting GYF protein-2 gene (GIGYF2) is a PARK11 gene that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France. However, no comprehensive study of the GIGYF2 gene has been conducted among PD patients from mainland China. In our previous study, the GIGYF2 gene was directly sequenced, and nine missense variants and 14 polymorphisms were identified. For these 14 polymorphisms, in the present study we performed a case–control analysis for 300 PD patients and 200 healthy controls from mainland China. The c.297T>C p.Ala99Ala polymorphism was associated with increased risk with respect to the pathogenesis of sporadic PD. In conclusion, within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing PD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Ji-Feng</ForeName>
<Initials>JF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Wen-Wen</ForeName>
<Initials>WW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Qian</ForeName>
<Initials>Q</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zuo</LastName>
<ForeName>Xing</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Chang-He</ForeName>
<Initials>CH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Lin-Zi</ForeName>
<Initials>LZ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Jia</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Liang</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Ya-Cen</ForeName>
<Initials>YC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Xin-Xiang</ForeName>
<Initials>XX</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Bei-Sha</ForeName>
<Initials>BS</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Scotland</Country>
<MedlineTA>J Clin Neurosci</MedlineTA>
<NlmUniqueID>9433352</NlmUniqueID>
<ISSNLinking>0967-5868</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C478016">GIGYF2 protein, human</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044466" MajorTopicYN="N">Asian Continental Ancestry Group</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056726" MajorTopicYN="N">Genetic Association Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year>
<Month>10</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2011</Year>
<Month>05</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>05</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>11</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>11</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>7</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22115759</ArticleId>
<ArticleId IdType="pii">S0967-5868(11)00355-9</ArticleId>
<ArticleId IdType="doi">10.1016/j.jocn.2011.05.014</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000923 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000923 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:22115759 |texte= Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:22115759" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
This area was generated with Dilib version V0.6.29. |