Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.
Identifieur interne : 000261 ( PubMed/Corpus ); précédent : 000260; suivant : 000262Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.
Auteurs : Frédéric Moisan ; Johan Spinosi ; Laurène Delabre ; Véronique Gourlet ; Jean-Louis Mazurie ; Isabelle Bénatru ; Marcel Goldberg ; Marc G. Weisskopf ; Ellen Imbernon ; Christophe Tzourio ; Alexis ElbazSource :
- Environmental health perspectives [ 1552-9924 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Case-Control Studies, Farmers (statistics & numerical data), France (epidemiology), Humans, Logistic Models, Male, Middle Aged, Occupational Exposure (statistics & numerical data), Odds Ratio, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Pesticides (adverse effects), Vitis.
- MESH :
- chemical , adverse effects : Pesticides.
- geographic , epidemiology : France.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- statistics & numerical data : Farmers, Occupational Exposure.
- Adult, Aged, Case-Control Studies, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Vitis.
Abstract
Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes.
DOI: 10.1289/ehp.1307970
PubMed: 25815770
Links to Exploration step
pubmed:25815770Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.</title><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation><nlm:affiliation>Département santé travail, Institut de veille sanitaire, Saint-Maurice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Spinosi, Johan" sort="Spinosi, Johan" uniqKey="Spinosi J" first="Johan" last="Spinosi">Johan Spinosi</name></author><author><name sortKey="Delabre, Laurene" sort="Delabre, Laurene" uniqKey="Delabre L" first="Laurène" last="Delabre">Laurène Delabre</name></author><author><name sortKey="Gourlet, Veronique" sort="Gourlet, Veronique" uniqKey="Gourlet V" first="Véronique" last="Gourlet">Véronique Gourlet</name></author><author><name sortKey="Mazurie, Jean Louis" sort="Mazurie, Jean Louis" uniqKey="Mazurie J" first="Jean-Louis" last="Mazurie">Jean-Louis Mazurie</name></author><author><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Bénatru">Isabelle Bénatru</name></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name></author><author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G" last="Weisskopf">Marc G. Weisskopf</name></author><author><name sortKey="Imbernon, Ellen" sort="Imbernon, Ellen" uniqKey="Imbernon E" first="Ellen" last="Imbernon">Ellen Imbernon</name></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25815770</idno><idno type="pmid">25815770</idno><idno type="doi">10.1289/ehp.1307970</idno><idno type="wicri:Area/PubMed/Corpus">000261</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000261</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.</title><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation><nlm:affiliation>Département santé travail, Institut de veille sanitaire, Saint-Maurice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Spinosi, Johan" sort="Spinosi, Johan" uniqKey="Spinosi J" first="Johan" last="Spinosi">Johan Spinosi</name></author><author><name sortKey="Delabre, Laurene" sort="Delabre, Laurene" uniqKey="Delabre L" first="Laurène" last="Delabre">Laurène Delabre</name></author><author><name sortKey="Gourlet, Veronique" sort="Gourlet, Veronique" uniqKey="Gourlet V" first="Véronique" last="Gourlet">Véronique Gourlet</name></author><author><name sortKey="Mazurie, Jean Louis" sort="Mazurie, Jean Louis" uniqKey="Mazurie J" first="Jean-Louis" last="Mazurie">Jean-Louis Mazurie</name></author><author><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Bénatru">Isabelle Bénatru</name></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name></author><author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G" last="Weisskopf">Marc G. Weisskopf</name></author><author><name sortKey="Imbernon, Ellen" sort="Imbernon, Ellen" uniqKey="Imbernon E" first="Ellen" last="Imbernon">Ellen Imbernon</name></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author></analytic><series><title level="j">Environmental health perspectives</title><idno type="eISSN">1552-9924</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Farmers (statistics & numerical data)</term><term>France (epidemiology)</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Occupational Exposure (statistics & numerical data)</term><term>Odds Ratio</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Pesticides (adverse effects)</term><term>Vitis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Farmers</term><term>Occupational Exposure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Vitis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25815770</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>26</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-9924</ISSN><JournalIssue CitedMedium="Internet"><Volume>123</Volume><Issue>11</Issue><PubDate><Year>2015</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Environmental health perspectives</Title><ISOAbbreviation>Environ. Health Perspect.</ISOAbbreviation></Journal><ArticleTitle>Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.</ArticleTitle><Pagination><MedlinePgn>1123-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1289/ehp.1307970</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">As part of a French population-based case-control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CIs) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models, as well as a synergistic interaction between duration and intensity (p-interaction = 0.04). High-intensity exposure to insecticides was positively associated with PD among those with low-intensity exposure to fungicides and vice versa, suggesting independent effects. Pesticide exposure in farms that specialized in vineyards was associated with PD (OR = 2.56; 95% CI: 1.31, 4.98). The association with intensity of pesticide use was stronger, although not significantly (p-heterogeneity = 0.60), for tremor-dominant (p-trend < 0.01) than for non-tremor-dominant PD (p-trend = 0.24).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor-dominant PD in men, the most typical PD presentation.</AbstractText><AbstractText Label="CITATION" NlmCategory="BACKGROUND">Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. 2015. Association of Parkinson's disease and its subtypes with agricultural pesticide exposures in men: a case-control study in France. Environ Health Perspect 123:1123-1129; http://dx.doi.org/10.1289/ehp.1307970.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moisan</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département santé travail, Institut de veille sanitaire, Saint-Maurice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spinosi</LastName><ForeName>Johan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Delabre</LastName><ForeName>Laurène</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Gourlet</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Mazurie</LastName><ForeName>Jean-Louis</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Bénatru</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Goldberg</LastName><ForeName>Marcel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Weisskopf</LastName><ForeName>Marc G</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Imbernon</LastName><ForeName>Ellen</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>Christophe</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Elbaz</LastName><ForeName>Alexis</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Environ Health Perspect</MedlineTA><NlmUniqueID>0330411</NlmUniqueID><ISSNLinking>0091-6765</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010575">Pesticides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int Arch Occup Environ Health. 2002 Aug;75(6):406-14</RefSource><PMID Version="1">12070637</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Occup Hyg. 2001 Apr;45(3):227-39</RefSource><PMID Version="1">11295146</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1999 Apr 12;52(6):1214-20</RefSource><PMID Version="1">10214746</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Apr 11;66(7):968-75</RefSource><PMID Version="1">16606907</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Pharmacol Sci. 2008 Jun;29(6):322-9</RefSource><PMID Version="1">18453001</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Occup Hyg. 2009 Jan;53(1):69-81</RefSource><PMID Version="1">19022871</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2009 Oct;66(4):494-504</RefSource><PMID Version="1">19847896</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2009 Nov;132(Pt 11):2947-57</RefSource><PMID Version="1">19759203</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2010 Mar 30;74(13):1055-61</RefSource><PMID Version="1">20350979</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2010 May;34(4):335-43</RefSource><PMID Version="1">20039379</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2010 Jun;16(6):653-61</RefSource><PMID Version="1">20495568</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2010 Jun 15;25(8):969-78</RefSource><PMID Version="1">20535823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2010 Jul;67(7):798-801</RefSource><PMID Version="1">20625084</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2011 May;69(5):803-10</RefSource><PMID Version="1">21246604</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Epidemiol. 2011 Jun;26 Suppl 1:S1-58</RefSource><PMID Version="1">21626386</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2011 Jun;119(6):866-72</RefSource><PMID Version="1">21269927</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2011 Aug 1;174(3):354-63</RefSource><PMID Version="1">21606234</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Epidemiol. 2011 Jul;26(7):547-55</RefSource><PMID Version="1">21505849</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Scand J Work Environ Health. 2011 Sep;37(5):427-36</RefSource><PMID Version="1">21240453</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotoxicology. 2011 Oct;32(5):640-5</RefSource><PMID Version="1">21620887</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2012 Mar;120(3):340-7</RefSource><PMID Version="1">22389202</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(10):e46813</RefSource><PMID Version="1">23056463</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2013 Apr;84(4):409-15</RefSource><PMID Version="1">22952329</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epidemiology. 1995 Jul;6(4):450-4</RefSource><PMID Version="1">7548361</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000067565" MajorTopicYN="N">Farmers</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016273" MajorTopicYN="N">Occupational Exposure</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027843" MajorTopicYN="N">Vitis</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4629732</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>12</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>03</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25815770</ArticleId><ArticleId IdType="doi">10.1289/ehp.1307970</ArticleId><ArticleId IdType="pmc">PMC4629732</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000261 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000261 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25815770
|texte= Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25815770" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |