A prospective single-blind study of Gamma Knife thalamotomy for tremor.
Identifieur interne : 000260 ( PubMed/Corpus ); précédent : 000259; suivant : 000261A prospective single-blind study of Gamma Knife thalamotomy for tremor.
Auteurs : Tatiana Witjas ; Romain Carron ; Paul Krack ; Alexandre Eusebio ; Marianne Vaugoyeau ; Marwan Hariz ; Jean Philippe Azulay ; Jean RégisSource :
- Neurology [ 1526-632X ] ; 2015.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Aged, 80 and over, Cohort Studies, Essential Tremor (surgery), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Prospective Studies, Radiosurgery, Severity of Illness Index, Single-Blind Method, Thalamus (surgery), Treatment Outcome, Tremor (etiology), Tremor (surgery), Ventral Thalamic Nuclei (surgery).
- MESH :
- complications : Parkinson Disease.
- etiology : Tremor.
- surgery : Essential Tremor, Thalamus, Tremor, Ventral Thalamic Nuclei.
- Activities of Daily Living, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Radiosurgery, Severity of Illness Index, Single-Blind Method, Treatment Outcome.
Abstract
To evaluate the safety and efficacy of unilateral Gamma Knife thalamotomy (GKT) for treatment of severe tremor with a prospective blinded assessment.
DOI: 10.1212/WNL.0000000000002087
PubMed: 26446066
Links to Exploration step
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A prospective single-blind study of Gamma Knife thalamotomy for tremor.</title><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France. tatiana.witjas@ap-hm.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Carron, Romain" sort="Carron, Romain" uniqKey="Carron R" first="Romain" last="Carron">Romain Carron</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hariz, Marwan" sort="Hariz, Marwan" uniqKey="Hariz M" first="Marwan" last="Hariz">Marwan Hariz</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Régis">Jean Régis</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26446066</idno><idno type="pmid">26446066</idno><idno type="doi">10.1212/WNL.0000000000002087</idno><idno type="wicri:Area/PubMed/Corpus">000260</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000260</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A prospective single-blind study of Gamma Knife thalamotomy for tremor.</title><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France. tatiana.witjas@ap-hm.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Carron, Romain" sort="Carron, Romain" uniqKey="Carron R" first="Romain" last="Carron">Romain Carron</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hariz, Marwan" sort="Hariz, Marwan" uniqKey="Hariz M" first="Marwan" last="Hariz">Marwan Hariz</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Régis">Jean Régis</name><affiliation><nlm:affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Essential Tremor (surgery)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Prospective Studies</term><term>Radiosurgery</term><term>Severity of Illness Index</term><term>Single-Blind Method</term><term>Thalamus (surgery)</term><term>Treatment Outcome</term><term>Tremor (etiology)</term><term>Tremor (surgery)</term><term>Ventral Thalamic Nuclei (surgery)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Essential Tremor</term><term>Thalamus</term><term>Tremor</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Radiosurgery</term><term>Severity of Illness Index</term><term>Single-Blind Method</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the safety and efficacy of unilateral Gamma Knife thalamotomy (GKT) for treatment of severe tremor with a prospective blinded assessment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26446066</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>08</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>85</Volume><Issue>18</Issue><PubDate><Year>2015</Year><Month>Nov</Month><Day>03</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>A prospective single-blind study of Gamma Knife thalamotomy for tremor.</ArticleTitle><Pagination><MedlinePgn>1562-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0000000000002087</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the safety and efficacy of unilateral Gamma Knife thalamotomy (GKT) for treatment of severe tremor with a prospective blinded assessment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fifty patients (mean age: 74.5 years; 32 men) with severe refractory tremor (36 essential, 14 parkinsonian) were treated with unilateral GKT. Targeting of the ventral intermediate nucleus (Vim) was achieved with Leksell Gamma Knife with a single shot through a 4-mm collimator helmet. The prescription dose was 130 Gy. Neurologic and neuropsychological assessments including a single-blinded video assessment of the tremor severity performed by a movement disorders neurologist from another center were performed before and 12 months after treatment. MRI follow-up occurred at 3, 6, and 12 months.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The upper limb tremor score improved by 54.2% on the blinded assessment (p < 0.0001). All tremor components (rest, postural, and intention) were improved. Activities of daily living were improved by 72.2%. Cognitive functions remained unchanged. Following GKT, the median delay of improvement was 5.3 months (range 1-12 months). The only side effect was a transient hemiparesis associated with excessive edema around the thalamotomy in one patient.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This blinded prospective assessment demonstrates that unilateral GKT is a safe and efficient procedure for severe medically refractory tremor. Side effects were rare and transient in this study.</AbstractText><AbstractText Label="CLASSIFICATION OF EVIDENCE" NlmCategory="METHODS">This study provides Class IV evidence that for patients with severe refractory tremor, GKT is well tolerated and effective in reducing tremor impairment.</AbstractText><CopyrightInformation>© 2015 American Academy of Neurology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Witjas</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France. tatiana.witjas@ap-hm.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carron</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krack</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eusebio</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaugoyeau</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hariz</LastName><ForeName>Marwan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azulay</LastName><ForeName>Jean Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Régis</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D000068397">Clinical Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000203" MajorTopicYN="Y">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020329" MajorTopicYN="N">Essential Tremor</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016634" MajorTopicYN="N">Radiosurgery</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013788" MajorTopicYN="N">Thalamus</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014202" MajorTopicYN="N">Tremor</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020651" MajorTopicYN="N">Ventral Thalamic Nuclei</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26446066</ArticleId><ArticleId IdType="pii">WNL.0000000000002087</ArticleId><ArticleId IdType="doi">10.1212/WNL.0000000000002087</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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