Deficit of verb generation in nondemented patients with Parkinson's disease.
Identifieur interne : 001009 ( PubMed/Checkpoint ); précédent : 001008; suivant : 001010Deficit of verb generation in nondemented patients with Parkinson's disease.
Auteurs : Patrice Péran [France] ; Olivier Rascol ; Jean-François Démonet ; Pierre Celsis ; Jean-Luc Nespoulous ; Bruno Dubois ; Dominique CardebatSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Cognition, Female, Humans, Language Disorders (diagnosis), Language Disorders (etiology), Language Tests, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Prefrontal Cortex (physiopathology), Severity of Illness Index, Vocabulary.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease.
- diagnosis : Language Disorders.
- drug therapy : Parkinson Disease.
- etiology : Language Disorders.
- physiopathology : Parkinson Disease, Prefrontal Cortex.
- Cognition, Female, Humans, Language Tests, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Vocabulary.
Abstract
Clinical and neuroimaging studies have shown that verb processing suggests a preferential participation of a prefrontal network, which is dysfunctional in Parkinson's disease (PD). To assess a verb processing deficit in PD, we compared noun- and verb-generation tasks for 34 nondemented PD patients (according to the Dementia Rating Scale) with 34 matched normal subjects, using two intracategory tasks (noun/noun and verb/verb generation) and two intercategory tasks (noun/verb and verb/noun generation). PD patients were significantly impaired in the two tasks involving verb production, i.e., verb/verb and noun/verb generation, whereas their performance was similar to those of controls in the two tasks requiring noun production. For the two impaired tasks, we assessed 1) the influence of lexical competition that corresponds to the presence of several candidate words for a given stimulus; 2) the influence of slight cognitive dysfunction; and 3) the influence of motor deficit. Significant correlations were found between DRS scores and performance on the noun/verb task, and no significant correlations were found between lexical competition or motor deficit and performance. The specific deficit for verb production in PD patients is discussed in relation to deficits affecting either action or grammatical representations.
DOI: 10.1002/mds.10306
PubMed: 12539207
Affiliations:
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To assess a verb processing deficit in PD, we compared noun- and verb-generation tasks for 34 nondemented PD patients (according to the Dementia Rating Scale) with 34 matched normal subjects, using two intracategory tasks (noun/noun and verb/verb generation) and two intercategory tasks (noun/verb and verb/noun generation). PD patients were significantly impaired in the two tasks involving verb production, i.e., verb/verb and noun/verb generation, whereas their performance was similar to those of controls in the two tasks requiring noun production. For the two impaired tasks, we assessed 1) the influence of lexical competition that corresponds to the presence of several candidate words for a given stimulus; 2) the influence of slight cognitive dysfunction; and 3) the influence of motor deficit. Significant correlations were found between DRS scores and performance on the noun/verb task, and no significant correlations were found between lexical competition or motor deficit and performance. The specific deficit for verb production in PD patients is discussed in relation to deficits affecting either action or grammatical representations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12539207</PMID><DateCreated><Year>2003</Year><Month>01</Month><Day>22</Day></DateCreated><DateCompleted><Year>2003</Year><Month>06</Month><Day>04</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>2</Issue><PubDate><Year>2003</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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For the two impaired tasks, we assessed 1) the influence of lexical competition that corresponds to the presence of several candidate words for a given stimulus; 2) the influence of slight cognitive dysfunction; and 3) the influence of motor deficit. Significant correlations were found between DRS scores and performance on the noun/verb task, and no significant correlations were found between lexical competition or motor deficit and performance. 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first="Pierre" last="Celsis">Pierre Celsis</name><name sortKey="Demonet, Jean Francois" sort="Demonet, Jean Francois" uniqKey="Demonet J" first="Jean-François" last="Démonet">Jean-François Démonet</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Nespoulous, Jean Luc" sort="Nespoulous, Jean Luc" uniqKey="Nespoulous J" first="Jean-Luc" last="Nespoulous">Jean-Luc Nespoulous</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Peran, Patrice" sort="Peran, Patrice" uniqKey="Peran P" first="Patrice" last="Péran">Patrice Péran</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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